Featured Research

from universities, journals, and other organizations

Inhibitors Of The Molecule PI3K Throw One Form Of Leukemia A CurveB-ALL

Date:
August 26, 2008
Source:
Journal of Clinical Investigation
Summary:
Some cases of a form of leukemia known as pre-B cell acute lymphoblastic leukemia (pre-B-ALL) are caused by a genetic event that leads to the generation of a rogue chromosome known as the Philadelphia (Ph) chomosome, and individuals with Ph+ pre-B-ALL tend to have a poor outlook. As current treatments for Ph+ pre-B-ALL are not very effective, researchers are looking for new drugs to combat this disease.

Some cases of a form of leukemia known as pre–B cell acute lymphoblastic leukemia (pre–B-ALL) are caused by a genetic event that leads to the generation of a rogue chromosome known as the Philadelphia (Ph) chomosome, and individuals with Ph+ pre–B-ALL tend to have a poor outlook. As current treatments for Ph+ pre–B-ALL are not very effective, researchers are looking for new drugs to combat this disease.

Related Articles


And now, David Fruman and colleagues, at the University of California, at Irvine, have generated data in mice and human cells that might provide insight into a new molecule to target in this clinical setting.

In the study, deletion of two genes responsible for generating a molecule known as PI3K prevented the development of disease in a mouse model of Ph+ pre–B-ALL. Consistent with an important role for PI3K in the development of Ph+ pre–B-ALL, a drug that inhibits PI3K as well as another signaling molecule known as mTOR suppressed the growth of mouse B-ALL and human Ph+ ALL leukemia cells in vitro.

The authors therefore suggest that targeting PI3K, either alone or together with mTOR, might prove beneficial to individuals with of Ph+ pre–B-ALL.


Story Source:

The above story is based on materials provided by Journal of Clinical Investigation. Note: Materials may be edited for content and length.


Journal Reference:

  1. Kharas et al. Ablation of PI3K blocks BCR-ABL leukemogenesis in mice, and a dual PI3K/mTOR inhibitor prevents expansion of human BCR-ABL leukemia cells
. Journal of Clinical Investigation, 2008; DOI: 10.1172/JCI33337

Cite This Page:

Journal of Clinical Investigation. "Inhibitors Of The Molecule PI3K Throw One Form Of Leukemia A CurveB-ALL." ScienceDaily. ScienceDaily, 26 August 2008. <www.sciencedaily.com/releases/2008/08/080815091952.htm>.
Journal of Clinical Investigation. (2008, August 26). Inhibitors Of The Molecule PI3K Throw One Form Of Leukemia A CurveB-ALL. ScienceDaily. Retrieved April 1, 2015 from www.sciencedaily.com/releases/2008/08/080815091952.htm
Journal of Clinical Investigation. "Inhibitors Of The Molecule PI3K Throw One Form Of Leukemia A CurveB-ALL." ScienceDaily. www.sciencedaily.com/releases/2008/08/080815091952.htm (accessed April 1, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Wednesday, April 1, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

7-Year-Old Girl Gets 3-D Printed 'robohand'

7-Year-Old Girl Gets 3-D Printed 'robohand'

AP (Mar. 31, 2015) — Although she never had much interest in prosthetic limbs before, Faith Lennox couldn&apos;t wait to slip on her new robohand. The 7-year-old, who lost part of her left arm when she was a baby, grabbed it as soon as it came off a 3-D printer. (March 31) Video provided by AP
Powered by NewsLook.com
Solitair Device Aims to Takes Guesswork out of Sun Safety

Solitair Device Aims to Takes Guesswork out of Sun Safety

Reuters - Innovations Video Online (Mar. 31, 2015) — The Solitair device aims to take the confusion out of how much sunlight we should expose our skin to. Small enough to be worn as a tie or hair clip, it monitors the user&apos;s sun exposure by taking into account their skin pigment, location and schedule. Matthew Stock reports. Video provided by Reuters
Powered by NewsLook.com
Soda, Salt and Sugar: The Next Generation of Taxes

Soda, Salt and Sugar: The Next Generation of Taxes

Washington Post (Mar. 30, 2015) — Denisa Livingston, a health advocate for the Dinι Community Advocacy Alliance, and the Post&apos;s Abby Phillip discuss efforts around the country to make unhealthy food choices hurt your wallet as much as your waistline. Video provided by Washington Post
Powered by NewsLook.com
UnitedHealth Buys Catamaran

UnitedHealth Buys Catamaran

Reuters - Business Video Online (Mar. 30, 2015) — The $12.8 billion merger will combine the U.S.&apos; third and fourth largest pharmacy benefit managers. Analysts say smaller PBMs could also merge. Fred Katayama reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins