Featured Research

from universities, journals, and other organizations

Lack Of Tuberculosis Trials In Children Unacceptable, Experts Argue

Date:
August 20, 2008
Source:
Public Library of Science
Summary:
Ensuring the involvement of children in the evaluation of tuberculosis treatment is critical as we move forward in developing effective responses to active and drug-susceptible tuberculosis, argues a new essay in PLoS Medicine.

Ensuring the involvement of children in the evaluation of tuberculosis treatment is critical as we move forward in developing effective responses to active and drug-susceptible tuberculosis (TB), argues a new essay in the journal PLoS Medicine.

Related Articles


William Burman (from the Denver Public Health and the University of Colorado Health Sciences Center, Denver, USA) and colleagues say that children are an often ignored but important part of tuberculosis control efforts. In high-burden settings, children make up as much as 20% of new cases of active tuberculosis. Young children are also at high risk of having severe, rapidly-progressive forms of tuberculosis.

But nearly 40 years after the development of short-course treatments in adults, there are still major uncertainties about dosing for children of common TB drugs. "Only in recent years has there been a substantial effort to manufacture child-friendly formulations of first-line tuberculosis drugs (such as crushable mini-pills, granules, oral suspensions)," say the authors. "And in the past 15 years, children have been included in only one study of new agents for tuberculosis: a large Phase 3 trial evaluating once-weekly rifapentine + isoniazid for treatment of latent tuberculosis."

Including children in drug development is especially critical, say the authors, as the two main threats to tuberculosis control—HIV-related immunodeficiency and drug-resistant tuberculosis—challenge our ability to develop effective drug regimens.

Burman and colleagues outline several traditional barriers to the involvement of children in tuberculosis drug development such as difficulty confirming TB diagnosis, concern about side effects, and regulatory requirements. But they also describe how these barriers can be overcome, arguing that researchers, regulatory agencies, advocates, and government agencies and private foundations that fund drug development must insist that the development pathways for all new treatments include specific plans for when and how children will be involved.

"Children have the same right to benefit from research as do adults," say the authors. "While this lack of involvement may be understandable in the short-term, it is not acceptable in the long-term."


Story Source:

The above story is based on materials provided by Public Library of Science. Note: Materials may be edited for content and length.


Journal Reference:

  1. Burman WJ, Cotton MF, Gibb DM, Walker AS, Vernon AA, et al. Assuring the involvement of children in the evaluation of new tuberculosis treatment regimens. PLoS Med, 5(8): e176 DOI: 10.1371/journal.pmed.0050176

Cite This Page:

Public Library of Science. "Lack Of Tuberculosis Trials In Children Unacceptable, Experts Argue." ScienceDaily. ScienceDaily, 20 August 2008. <www.sciencedaily.com/releases/2008/08/080818220559.htm>.
Public Library of Science. (2008, August 20). Lack Of Tuberculosis Trials In Children Unacceptable, Experts Argue. ScienceDaily. Retrieved March 5, 2015 from www.sciencedaily.com/releases/2008/08/080818220559.htm
Public Library of Science. "Lack Of Tuberculosis Trials In Children Unacceptable, Experts Argue." ScienceDaily. www.sciencedaily.com/releases/2008/08/080818220559.htm (accessed March 5, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Thursday, March 5, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Bupa Eyes India Healthcare Opportunities

Bupa Eyes India Healthcare Opportunities

Reuters - Business Video Online (Mar. 5, 2015) — Bupa is hoping to expand in India&apos;s fast-growing health insurance market, once a rule change on foreign investment is implemented. The British private healthcare group&apos;s CEO tells Grace Pascoe why it&apos;s so keen on the new opportunity. Video provided by Reuters
Powered by NewsLook.com
Doctor in Your Pocket Is Getting Smarter

Doctor in Your Pocket Is Getting Smarter

Reuters - Business Video Online (Mar. 5, 2015) — Mobile apps are turning smartphones into a personal doctors, with users able to measure heart rate, blood pressure and even blood sugar. But will it change our behaviour? Ivor Bennett reports from the Mobile World Congress in Barcelona. Video provided by Reuters
Powered by NewsLook.com
AbbVie Inks $21B Deal To Buy Cancer Drugmaker Pharmacyclics

AbbVie Inks $21B Deal To Buy Cancer Drugmaker Pharmacyclics

Newsy (Mar. 5, 2015) — AbbVie announced Wednesday it will buy cancer drugmaker Pharmacyclics in a $21 billion deal. Video provided by Newsy
Powered by NewsLook.com
Adults Only Get The Flu Twice A Decade, Researchers Say

Adults Only Get The Flu Twice A Decade, Researchers Say

Newsy (Mar. 4, 2015) — Researchers found adults only get the flu about once every five years. Scientists analyzed how a person&apos;s immunity builds up over time as well. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins