Featured Research

from universities, journals, and other organizations

New Guideline On Diagnosis And Treatment Of Primary Aldosteronism

Date:
August 28, 2008
Source:
The Endocrine Society
Summary:
The Endocrine Society has released a new clinical practice guideline for the detection, diagnosis, and treatment of patients with primary aldosteronism. The guidelines appear in the September issue of the Journal of Clinical Endocrinology & Metabolism, a publication of the Endocrine Society.

The Endocrine Society has released a new clinical practice guideline for the detection, diagnosis, and treatment of patients with primary aldosteronism. The guidelines appear in the September issue of the Journal of Clinical Endocrinology & Metabolism (JCEM), a publication of The Endocrine Society.

Related Articles


Primary aldosteronism (PA) refers to conditions in which production of aldosterone, a steroid hormone produced in the adrenal gland, is inappropriately high. Such inappropriate production of aldosteronism causes cardiovascular damage, hypertension, sodium retention, and potassium excretion that, if prolonged and severe, may lead to significant potassium deficiency. PA is commonly caused by benign tumors of the adrenal gland, over-activity of steroid producing cells in the adrenal cortex, or in rare cases by hereditary conditions or adrenal cancer.

"Studies show primary aldosteronism may be more prevalent than previously thought, affecting more than ten percent of hypertensive patients," said Dr. John Funder of Prince Henry's Institute of Medical Research in Clayton, Australia and chair of the task force that developed these guidelines. "The new guideline uses the best available research to help physicians diagnose primary aldosteronism and employ specific treatments that can alleviate the impact of this condition."

The guideline recommends that case detection of PA be sought in higher risk groups of hypertensive patients and those with potassium deficiency by determining the ratio of aldosterone to renin, an enzyme that regulates blood pressure. If this ratio is elevated, diagnosis should then be confirmed or excluded by commonly-used confirmatory tests.

If PA is confirmed, the guideline recommends that patients undergo adrenal computed tomography (CT) to exclude adrenocorticol carcinoma, followed by radiographic lateralization to determine whether PA is due to unilateral or bilateral oversecretion.

Lateralization is important because if only one of the two adrenal glands is responsible for oversecretion PA is best treated by laparoscopic surgery to remove the overproducing adrenal gland. For the bilateral form, medical therapy is the treatment of choice. When medical therapy is needed, the guideline recommends patients be treated with mineralocorticoid receptor antagonists, drugs which inhibit the action of aldosterone.

The new guideline was developed by a task force chaired by Dr. Funder. Other members of the task force included Robert M. Carey of the University of Virginia Health System in Charlottesville, Va.; Carlos Fardella of Facultad de Medicina Pontificia Universidad Catolica de Chile in Santiago, Chile; Celso Gomez-Sanchez of Montgomery VA Medical Center in Jackson, Miss.; Franco Mantero of the University of Padova in Padua, Italy; Michael Stowasser of the University of Queensland in Brisbane, Australia; and William Young, Jr. and Victor Montori of the Mayo Clinic in Rochester, Minn.


Story Source:

The above story is based on materials provided by The Endocrine Society. Note: Materials may be edited for content and length.


Cite This Page:

The Endocrine Society. "New Guideline On Diagnosis And Treatment Of Primary Aldosteronism." ScienceDaily. ScienceDaily, 28 August 2008. <www.sciencedaily.com/releases/2008/08/080828084052.htm>.
The Endocrine Society. (2008, August 28). New Guideline On Diagnosis And Treatment Of Primary Aldosteronism. ScienceDaily. Retrieved October 24, 2014 from www.sciencedaily.com/releases/2008/08/080828084052.htm
The Endocrine Society. "New Guideline On Diagnosis And Treatment Of Primary Aldosteronism." ScienceDaily. www.sciencedaily.com/releases/2008/08/080828084052.htm (accessed October 24, 2014).

Share This



More Health & Medicine News

Friday, October 24, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

IKEA Desk Converts From Standing to Sitting With One Button

IKEA Desk Converts From Standing to Sitting With One Button

Buzz60 (Oct. 24, 2014) IKEA is out with a new convertible desk that can convert from a sitting desk to a standing one with just the push of a button. Jen Markham explains. Video provided by Buzz60
Powered by NewsLook.com
Ebola Protective Suits Being Made in China

Ebola Protective Suits Being Made in China

AFP (Oct. 24, 2014) A factory in China is busy making Ebola protective suits for healthcare workers and others fighting the spread of the virus. Duration: 00:38 Video provided by AFP
Powered by NewsLook.com
WHO: Millions of Ebola Vaccine Doses by 2015

WHO: Millions of Ebola Vaccine Doses by 2015

AP (Oct. 24, 2014) The World Health Organization said on Friday that millions of doses of two experimental Ebola vaccines could be ready for use in 2015 and five more experimental vaccines would start being tested in March. (Oct. 24) Video provided by AP
Powered by NewsLook.com
Doctor in NYC Quarantined With Ebola

Doctor in NYC Quarantined With Ebola

AP (Oct. 24, 2014) An emergency room doctor who recently returned to the city after treating Ebola patients in West Africa has tested positive for the virus. He's quarantined in a hospital. (Oct. 24) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins