Featured Research

from universities, journals, and other organizations

New Guideline On Diagnosis And Treatment Of Primary Aldosteronism

Date:
August 28, 2008
Source:
The Endocrine Society
Summary:
The Endocrine Society has released a new clinical practice guideline for the detection, diagnosis, and treatment of patients with primary aldosteronism. The guidelines appear in the September issue of the Journal of Clinical Endocrinology & Metabolism, a publication of the Endocrine Society.

The Endocrine Society has released a new clinical practice guideline for the detection, diagnosis, and treatment of patients with primary aldosteronism. The guidelines appear in the September issue of the Journal of Clinical Endocrinology & Metabolism (JCEM), a publication of The Endocrine Society.

Primary aldosteronism (PA) refers to conditions in which production of aldosterone, a steroid hormone produced in the adrenal gland, is inappropriately high. Such inappropriate production of aldosteronism causes cardiovascular damage, hypertension, sodium retention, and potassium excretion that, if prolonged and severe, may lead to significant potassium deficiency. PA is commonly caused by benign tumors of the adrenal gland, over-activity of steroid producing cells in the adrenal cortex, or in rare cases by hereditary conditions or adrenal cancer.

"Studies show primary aldosteronism may be more prevalent than previously thought, affecting more than ten percent of hypertensive patients," said Dr. John Funder of Prince Henry's Institute of Medical Research in Clayton, Australia and chair of the task force that developed these guidelines. "The new guideline uses the best available research to help physicians diagnose primary aldosteronism and employ specific treatments that can alleviate the impact of this condition."

The guideline recommends that case detection of PA be sought in higher risk groups of hypertensive patients and those with potassium deficiency by determining the ratio of aldosterone to renin, an enzyme that regulates blood pressure. If this ratio is elevated, diagnosis should then be confirmed or excluded by commonly-used confirmatory tests.

If PA is confirmed, the guideline recommends that patients undergo adrenal computed tomography (CT) to exclude adrenocorticol carcinoma, followed by radiographic lateralization to determine whether PA is due to unilateral or bilateral oversecretion.

Lateralization is important because if only one of the two adrenal glands is responsible for oversecretion PA is best treated by laparoscopic surgery to remove the overproducing adrenal gland. For the bilateral form, medical therapy is the treatment of choice. When medical therapy is needed, the guideline recommends patients be treated with mineralocorticoid receptor antagonists, drugs which inhibit the action of aldosterone.

The new guideline was developed by a task force chaired by Dr. Funder. Other members of the task force included Robert M. Carey of the University of Virginia Health System in Charlottesville, Va.; Carlos Fardella of Facultad de Medicina Pontificia Universidad Catolica de Chile in Santiago, Chile; Celso Gomez-Sanchez of Montgomery VA Medical Center in Jackson, Miss.; Franco Mantero of the University of Padova in Padua, Italy; Michael Stowasser of the University of Queensland in Brisbane, Australia; and William Young, Jr. and Victor Montori of the Mayo Clinic in Rochester, Minn.


Story Source:

The above story is based on materials provided by The Endocrine Society. Note: Materials may be edited for content and length.


Cite This Page:

The Endocrine Society. "New Guideline On Diagnosis And Treatment Of Primary Aldosteronism." ScienceDaily. ScienceDaily, 28 August 2008. <www.sciencedaily.com/releases/2008/08/080828084052.htm>.
The Endocrine Society. (2008, August 28). New Guideline On Diagnosis And Treatment Of Primary Aldosteronism. ScienceDaily. Retrieved July 24, 2014 from www.sciencedaily.com/releases/2008/08/080828084052.htm
The Endocrine Society. "New Guideline On Diagnosis And Treatment Of Primary Aldosteronism." ScienceDaily. www.sciencedaily.com/releases/2008/08/080828084052.htm (accessed July 24, 2014).

Share This




More Health & Medicine News

Thursday, July 24, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

New Painkiller Designed To Discourage Abuse: Will It Work?

New Painkiller Designed To Discourage Abuse: Will It Work?

Newsy (July 24, 2014) The FDA approved Targiniq ER on Wednesday, a painkiller designed to keep users from abusing it. Like any new medication, however, it has doubters. Video provided by Newsy
Powered by NewsLook.com
Doctor At Forefront Of Fighting Ebola Outbreak Gets Ebola

Doctor At Forefront Of Fighting Ebola Outbreak Gets Ebola

Newsy (July 24, 2014) Sheik Umar Khan has treated many of the people infected in the Ebola outbreak, and now he's become one of them. Video provided by Newsy
Powered by NewsLook.com
Condemned Man's US Execution Takes Nearly Two Hours

Condemned Man's US Execution Takes Nearly Two Hours

AFP (July 24, 2014) America's death penalty debate raged Thursday after it took nearly two hours for Arizona to execute a prisoner who lost a Supreme Court battle challenging the experimental lethal drug cocktail. Duration: 00:55 Video provided by AFP
Powered by NewsLook.com
China's Ageing Millions Look Forward to Bleak Future

China's Ageing Millions Look Forward to Bleak Future

AFP (July 24, 2014) China's elderly population is expanding so quickly that children struggle to look after them, pushing them to do something unexpected in Chinese society- move their parents into a nursing home. Duration: 02:07 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins