Featured Research

from universities, journals, and other organizations

Apples And Oranges: Tumor Blood Vessel Cells Are Remarkably Atypical

Date:
September 9, 2008
Source:
Cell Press
Summary:
Contrary to a long-standing assumption that blood vessel cells in healthy tissues and those associated with tumors are similar, a new study unequivocally demonstrates that tumor blood vessel cells are far from normal.

Contrary to a long-standing assumption that blood vessel cells in healthy tissues and those associated with tumors are similar, a new study unequivocally demonstrates that tumor blood vessel cells are far from normal. The research, published by Cell Press in the September issue of the journal Cancer Cell, identifies tumor-specific blood vessel cells that are atypically stem cell-like and have the potential to differentiate into cartilage- or bone-like tissues.

Although it has been known for some time that tumors can be eradicated in mice by targeting their blood supply, very little is known about the biology of the endothelial cells that line tumor blood vessels (TECs). "A primary assumption of antiangiogenesis therapy is that TECs are normal and derived from nearby, preexisting vessels," explains senior author Dr. Michael Klagsbrun from Children's Hospital Boston and Harvard Medical School. "However, we and other groups have shown that there are several key differences between normal and tumor endothelium."

Dr. Klagsbrun and lead author Dr. Andrew Dudley isolated TECs from mice that spontaneously develop prostate tumors very similar to human prostate cancers. The researchers found that the TECs were multipotent, meaning that they were not fully mature and had the potential to differentiate into multiple different types of cells. The isolated TECs differentiated to form cartilage- and bone-like tissues. "These results suggest that TECs possess a stem/progenitor cell property that distinguishes them from ECs throughout the normal vasculature and undergo atypical differentiation," explains Dr. Klagsbrun.

The researchers went on to demonstrate blood vessel calcification in human and mouse prostate tumor specimens. This bone-like calcification has also been described in diseased blood vessels and is likely to have clinical significance in prostate cancer. "It is possible that calcification of tumor blood vessels could impair blood flow or enable tumor cell entry into the bloodstream, facilitating metastasis," offers Dr. Klagsbrun. "Further, the expression of bone-specific proteins in prostate tumor cells may enable their survival once they reach the bone microenvironment."

Additional research is required to determine how the atypical properties of TECs are associated with the tortuous, leaky vessels characteristic of tumors and whether vascular calcification does indeed encourage tumor cell metastasis. It is also possible that vascular calcification, which is easily discernible histologically, may be a useful diagnostic criterion.

The researchers include Andrew C. Dudley, Children's Hospital Boston and Harvard Medical School, Boston, MA; Zia A. Khan, Children's Hospital Boston and Harvard Medical School, Boston, MA; Shou-Ching Shih, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA; Soo-Young Kang, Children's Hospital Boston and Harvard Medical School, Boston, MA; Bernadette M.M. Zwaans, Children's Hospital Boston and Harvard Medical School, Boston, MA; Joyce Bischoff, Children's Hospital Boston and Harvard Medical School, Boston, MA; and Michael Klagsbrun, Children's Hospital Boston and Harvard Medical School, Boston, MA.


Story Source:

The above story is based on materials provided by Cell Press. Note: Materials may be edited for content and length.


Journal Reference:

  1. Dudley et al. Calcification of Multipotent Prostate Tumor Endothelium. Cancer Cell, Vol 14, 201-211, 09 September 2008 [link]

Cite This Page:

Cell Press. "Apples And Oranges: Tumor Blood Vessel Cells Are Remarkably Atypical." ScienceDaily. ScienceDaily, 9 September 2008. <www.sciencedaily.com/releases/2008/09/080908135902.htm>.
Cell Press. (2008, September 9). Apples And Oranges: Tumor Blood Vessel Cells Are Remarkably Atypical. ScienceDaily. Retrieved September 21, 2014 from www.sciencedaily.com/releases/2008/09/080908135902.htm
Cell Press. "Apples And Oranges: Tumor Blood Vessel Cells Are Remarkably Atypical." ScienceDaily. www.sciencedaily.com/releases/2008/09/080908135902.htm (accessed September 21, 2014).

Share This



More Health & Medicine News

Sunday, September 21, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Sierra Leone in Lockdown to Control Ebola

Sierra Leone in Lockdown to Control Ebola

AP (Sep. 21, 2014) Sierra Leone residents remained in lockdown on Saturday as part of a massive effort to confine millions of people to their homes in a bid to stem the biggest Ebola outbreak in history. (Sept. 20) Video provided by AP
Powered by NewsLook.com
Sierra Leone's Nationwide Ebola Curfew Underway

Sierra Leone's Nationwide Ebola Curfew Underway

Newsy (Sep. 20, 2014) Sierra Leone is locked down as aid workers and volunteers look for new cases of Ebola. Video provided by Newsy
Powered by NewsLook.com
Changes Found In Brain After One Dose Of Antidepressants

Changes Found In Brain After One Dose Of Antidepressants

Newsy (Sep. 19, 2014) A study suggest antidepressants can kick in much sooner than previously thought. Video provided by Newsy
Powered by NewsLook.com
Could Grief Affect The Immune Systems Of Senior Citizens?

Could Grief Affect The Immune Systems Of Senior Citizens?

Newsy (Sep. 19, 2014) The study found elderly people are much more likely to become susceptible to infection than younger adults going though a similar situation. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins