Featured Research

from universities, journals, and other organizations

New Vaccine Element Could Generate Better Protection From Avian Influenza

Date:
September 24, 2008
Source:
Journal of Clinical Investigation
Summary:
Current vaccines for influenza provide protection against specific seasonal influenza A strains and their close relatives, but not against more distant seasonal influenza A viruses and new avian influenza A viruses, such as H5N1, which still poses a real global health concern. However, new data have been generated that suggest adding a new component to vaccines for influenza might enable them to confer protection against a broader range of avian and seasonal influenza A viruses.

Current vaccines for influenza provide protection against specific seasonal influenza A strains and their close relatives, but not against more distant seasonal influenza A viruses and new avian influenza A viruses, such as H5N1, which still poses a real global health concern.

However, a team of researchers led by Tao Dong and Andrew McMichael, at Oxford University, United Kingdom, has now generated data that suggest adding a new component to vaccines for influenza might enable them to confer protection against a broad range of avian and seasonal influenza A viruses. In an accompanying commentary, Peter Doherty and Anne Kelso discuss in more detail how the data generated in this paper might be translated into a new and improved vaccine.

In the study, subsets of immune cells known as memory CD4+ and memory CD8+ T cells from individuals from the United Kingdom and Viet Nam were found to respond to fragments of proteins from both a seasonal influenza A strain and a strain of H5N1. Nearly all people tested had cells that cross-reacted between the seasonal influenza A strain and H5N1.

The authors therefore suggest that adding fragments of influenza proteins to current vaccines for influenza might boost memory CD4+ and memory CD8+ T cell responses towards both seasonal and avian influenza viruses, providing broad protection.


Story Source:

The above story is based on materials provided by Journal of Clinical Investigation. Note: Materials may be edited for content and length.


Journal References:

  1. Lee et al. Memory T cells established by seasonal human influenza A infection cross-react with avian influenza A (H5N1) in healthy individuals. Journal of Clinical Investigation, 2008; DOI: 10.1172/JCI32460
  2. Peter C. Doherty and Anne Kelso. Toward a broadly protective influenza vaccine. Journal of Clinical Investigation, 2008; DOI: 10.1172/JCI37232

Cite This Page:

Journal of Clinical Investigation. "New Vaccine Element Could Generate Better Protection From Avian Influenza." ScienceDaily. ScienceDaily, 24 September 2008. <www.sciencedaily.com/releases/2008/09/080918192828.htm>.
Journal of Clinical Investigation. (2008, September 24). New Vaccine Element Could Generate Better Protection From Avian Influenza. ScienceDaily. Retrieved October 23, 2014 from www.sciencedaily.com/releases/2008/09/080918192828.htm
Journal of Clinical Investigation. "New Vaccine Element Could Generate Better Protection From Avian Influenza." ScienceDaily. www.sciencedaily.com/releases/2008/09/080918192828.htm (accessed October 23, 2014).

Share This



More Health & Medicine News

Thursday, October 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Ebola Fears Keep Guinea Hospitals Empty

Ebola Fears Keep Guinea Hospitals Empty

AP (Oct. 23, 2014) Fears of Ebola are keeping doctors and patients alike away from hospitals in the West African nation of Guinea. (Oct. 23) Video provided by AP
Powered by NewsLook.com
Orthodontist Mom Jennifer Salzer on the Best Time for Braces

Orthodontist Mom Jennifer Salzer on the Best Time for Braces

Working Mother (Oct. 22, 2014) Is your child ready? Video provided by Working Mother
Powered by NewsLook.com
U.S. Issues Ebola Travel Restrictions, Are Visa Bans Next?

U.S. Issues Ebola Travel Restrictions, Are Visa Bans Next?

Newsy (Oct. 22, 2014) Now that the U.S. is restricting travel from West Africa, some are dropping questions about a travel ban and instead asking about visa bans. Video provided by Newsy
Powered by NewsLook.com
More People Diagnosed With TB In 2013, But There's Good News

More People Diagnosed With TB In 2013, But There's Good News

Newsy (Oct. 22, 2014) The World Health Organizations says TB numbers rose in 2013, but it's partly due to better detection and more survivors. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins