Featured Research

from universities, journals, and other organizations

Pancreatic Cancer: New Options When An Old Enemy Returns

Date:
September 22, 2008
Source:
Georgetown University Medical Center
Summary:
Pancreatic cancer is one of the most challenging malignancies to treat, and recurrence is common, even after initial treatment with surgery and radiation. When the cancer does return, treatment options are often limited to chemotherapy, but researchers are now utilizing the precision allowed by CyberKnife to see if radiosurgery is a viable treatment option in select patients.

Pancreatic cancer is one of the most challenging malignancies to treat, and recurrence is common, even after initial treatment with surgery and radiation. When the cancer does return, treatment options are often limited to chemotherapy, but researchers at Georgetown's Lombardi Comprehensive Cancer Center are utilizing the precision allowed by CyberKnife® to see if radiosurgery is a viable treatment option in select patients.

Related Articles


"When treating recurrent pancreatic tumors, there are a number of factors to evaluate before we can consider radiosurgery as an additional treatment option," explains Christopher Lominska, M.D., lead author of the study and a resident in radiation medicine at Georgetown's Lombardi Comprehensive Cancer Center. "First, treatment must be safe, which is demonstrated in this study. We also designed a treatment that can be delivered in a short period of time -- a critically important quality-of-life factor in this patient population." The results of the study were presented today at the 50th annual meeting of the American Society for Therapeutic and Radiology Oncology (ASTRO) in Boston.

For the study, Lominska and his colleagues evaluated the safety of radiosurgery using CyberKnife® by reviewing the records of patients treated for pancreatic cancer at Georgetown from June 2002 through July 2007. Twenty-eight patients were treated for locally recurrent disease, 20 of whom had had prior chemotherapy and conventional radiation, and eight of whom had had prior surgery as well as radiation and chemotherapy. Disease recurrence was visualized with CT or PET/CT imaging.

The median age of the patients was 63 years old. Follow-up was available on 24 of 28 patients (patients lost to follow-up were assumed deceased). Median survival from the date of radiosurgery treatment was 5.3 months (range 1-27 months). Seven (7) patients (25 percent) lived more than 8 months after treatment.

"We found an acceptable safety profile for those receiving radiosurgery," says Lominska. "These patients had received full doses of conventional radiation therapy prior to their radiation treatment, so this speaks to the very high level of precision of the CyberKnife® -- that we were able to give them more radiation safely. It's also worth noting that treatment was delivered in only a week allowing patients to resume systemic chemotherapy with minimal interruption."

Lominska says only two patients experienced serious GI toxicity (one peripancreatic abscess, one bowel obstruction) after being treated with three sessions of radiosurgery. (Five sessions of daily treatment are now commonly given with the belief that this is better tolerated.) Review of radiographic studies revealed local control in 6 patients, local control with distant progression in 6 patients, and local and distant progression in two patients with no follow-up imaging available on the remaining patients. As of March 2008, 26/28 patients have died. The two surviving patients remain locally controlled without evidence of distant disease on follow-up of three and 8 months.

Lominska says the preliminary survival trends look good, but are not conclusive until more studies are designed to evaluate if radiosurgery with CyberKnife can extend survival when compared with usual care.

In addition to Lominska, other study authors include Nadim Nasr M.D., Natalie Silver M.S., and Gregory Gagnon M.D., all of Georgetown. The authors report the following disclosures: Gagnon occasionally serves as a paid consultant and receives speaking fees from Accuray, the manufacturer of the CyberKnife. There was no external funding for this study.


Story Source:

The above story is based on materials provided by Georgetown University Medical Center. Note: Materials may be edited for content and length.


Cite This Page:

Georgetown University Medical Center. "Pancreatic Cancer: New Options When An Old Enemy Returns." ScienceDaily. ScienceDaily, 22 September 2008. <www.sciencedaily.com/releases/2008/09/080921162008.htm>.
Georgetown University Medical Center. (2008, September 22). Pancreatic Cancer: New Options When An Old Enemy Returns. ScienceDaily. Retrieved October 25, 2014 from www.sciencedaily.com/releases/2008/09/080921162008.htm
Georgetown University Medical Center. "Pancreatic Cancer: New Options When An Old Enemy Returns." ScienceDaily. www.sciencedaily.com/releases/2008/09/080921162008.htm (accessed October 25, 2014).

Share This



More Health & Medicine News

Saturday, October 25, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

IKEA Desk Converts From Standing to Sitting With One Button

IKEA Desk Converts From Standing to Sitting With One Button

Buzz60 (Oct. 24, 2014) — IKEA is out with a new convertible desk that can convert from a sitting desk to a standing one with just the push of a button. Jen Markham explains. Video provided by Buzz60
Powered by NewsLook.com
Ebola Protective Suits Being Made in China

Ebola Protective Suits Being Made in China

AFP (Oct. 24, 2014) — A factory in China is busy making Ebola protective suits for healthcare workers and others fighting the spread of the virus. Duration: 00:38 Video provided by AFP
Powered by NewsLook.com
WHO: Millions of Ebola Vaccine Doses by 2015

WHO: Millions of Ebola Vaccine Doses by 2015

AP (Oct. 24, 2014) — The World Health Organization said on Friday that millions of doses of two experimental Ebola vaccines could be ready for use in 2015 and five more experimental vaccines would start being tested in March. (Oct. 24) Video provided by AP
Powered by NewsLook.com
Doctor in NYC Quarantined With Ebola

Doctor in NYC Quarantined With Ebola

AP (Oct. 24, 2014) — An emergency room doctor who recently returned to the city after treating Ebola patients in West Africa has tested positive for the virus. He's quarantined in a hospital. (Oct. 24) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins