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Low Sperm Count May Be Associated With Prenatal Testosterone Excess

Date:
September 26, 2008
Source:
The Endocrine Society
Summary:
Exposure to an excess of sexual steroids, like testosterone, during fetal development may be a potential risk factor for low sperm count and motility, according to a new study.

Exposure to an excess of sexual steroids, like testosterone, during fetal development may be a potential risk factor for low sperm count and motility, according to a new study.

"The majority of disorders affecting sperm count in humans are originated during fetal life," said Professor Sergio Recabarren of the University of Concepcion in Chillan, Chile and lead author of the study. "A developing fetus is very vulnerable to its environment, and when that environment is exposed to excess sexual steroids, it may have a significant deleterious effect on a male offspring's fertility."

Prenatal exposure to excess sexual steroids can occur in two ways, said Dr. Recabarren. First, the exposure may be a product of increased sexual steroids in the maternal environment due to a hormonal condition such as polycystic ovary syndrome. Second, humans are exposed to several industrial pollutants which can act as steroid mimics, causing the body to inhibit or accelerate native steroid production.

In this study, researchers treated pregnant sheep with 30 mg testosterone propionate twice weekly from days 30 to 90 of pregnancy and with 40 mg testosterone propionate from days 90 to 120 of pregnancy. They found a significant reduction in body weight, scrotal circumference, and sperm count in male sheep born to these mothers compared with control sheep.

"While this research involved sheep, it can certainly be argued that in humans, exposure to an excess of sexual steroids during fetal development could constitute a potential risk factor that may conduct to a low sperm count," said Dr. Recabarren.

Low sperm counts are also associated with testicular cancer, with an incidence rate 20 fold higher than men with normal sperm analysis, said Dr. Recabarren. The findings from this study highlight growing concerns of the detrimental effects of prenatal steroid excess on reduced sperm counts.

Other researchers working on the study include Pedro Rojas-Garcia, Monica Recabarren, and Victor Alfaro of the University of Concepcion in Chillan, Chile; Rosita Smith and Teresa Sir-Petermann of the University of Chile in Santiago; and Vasantha Padmanabhan of the University of Michigan in Ann Arbor.


Story Source:

The above story is based on materials provided by The Endocrine Society. Note: Materials may be edited for content and length.


Journal Reference:

  1. Recabarren et al. Prenatal Testosterone Excess Reduces Sperm Count and Motility. Endocrinology, December 2008; DOI: 10.1210/en.2008-0785

Cite This Page:

The Endocrine Society. "Low Sperm Count May Be Associated With Prenatal Testosterone Excess." ScienceDaily. ScienceDaily, 26 September 2008. <www.sciencedaily.com/releases/2008/09/080923082158.htm>.
The Endocrine Society. (2008, September 26). Low Sperm Count May Be Associated With Prenatal Testosterone Excess. ScienceDaily. Retrieved July 28, 2014 from www.sciencedaily.com/releases/2008/09/080923082158.htm
The Endocrine Society. "Low Sperm Count May Be Associated With Prenatal Testosterone Excess." ScienceDaily. www.sciencedaily.com/releases/2008/09/080923082158.htm (accessed July 28, 2014).

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