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What Is The Best Strategy For Treating Helicobacter Pylori?

Date:
September 24, 2008
Source:
World Journal of Gastroenterology
Summary:
The best treatment for Helicobacter pylori is not yet established. The organism is becoming resistant to some of the treatments. This study compared the standard three drug treatment with a four drug treatment in a rural hospital in UK. They concluded that four drugs remain the best option for white Caucasians in rural UK, except for some the side effects.

The most popular treatment for H pylori is triple therapy but resistance to Clarithromycin is reducing its effectiveness. Courses using four drugs have been known to be more successful but are used less popular because of their side-effects. While, what is the best way for treating H pylori-related diseases.

A new research article addresses this question. The research team led by Prof. Mr Siok Ching from United Kingdom compared a lansoprazole-based triple versus quadruple therapy for H pylori eradication with emphasis on side effect profile, patient compliance and eradication rate at a rural district general hospital in Wales, United Kingdom.

Overall the treatment of H Pylori using both three drugs and four drugs are still highly effective in rural North Wales (92%), however, almost all (97%) of the patients who managed to complete the course of four tablets got rid of the infection.

Authors feel that treatments with four drugs remain the best option for white Caucasians in rural UK. Patients need educating about the side effects of the drugs and the reasons for treatment so that they can reap the full benefits.

They concluded that one-week triple and quadruple therapies have similar intention-to-treat eradication rates. Certain side effects are more common with quadruple therapy, which can compromise patient compliance. Patient education or modifications to the regimen are alternative options to improve compliance of the quadruple regimen.

The side effects may be reduced by replacing metronidazole with amoxycillin but patients should be better educated about the side effects in order to improve compliance and cure rates.


Story Source:

The above story is based on materials provided by World Journal of Gastroenterology. Note: Materials may be edited for content and length.


Journal Reference:

  1. Ching SS, Sabanathan S, Jenkinson LR. Treatment of H pylori in surgical practice: A randomised trial of triple versus quadruple therapy in a rural district general hospital. World Journal of Gastroenterology, 28 June 2008; 14(24): 3855-3860 [link]

Cite This Page:

World Journal of Gastroenterology. "What Is The Best Strategy For Treating Helicobacter Pylori?." ScienceDaily. ScienceDaily, 24 September 2008. <www.sciencedaily.com/releases/2008/09/080923104313.htm>.
World Journal of Gastroenterology. (2008, September 24). What Is The Best Strategy For Treating Helicobacter Pylori?. ScienceDaily. Retrieved July 31, 2014 from www.sciencedaily.com/releases/2008/09/080923104313.htm
World Journal of Gastroenterology. "What Is The Best Strategy For Treating Helicobacter Pylori?." ScienceDaily. www.sciencedaily.com/releases/2008/09/080923104313.htm (accessed July 31, 2014).

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