Featured Research

from universities, journals, and other organizations

Mechanism Used By Gene To Promote Metastasis In Human Cancer Cells Identified

Date:
October 1, 2008
Source:
Virginia Commonwealth University
Summary:
Researchers have discovered how a gene, melanoma differentiation associated gene-9/syntenin (mda-9/syntenin), interacts with an important signaling protein to promote metastasis in human melanoma cells, a discovery that could one day lead to the development of the next generation of anti-metastatic drugs for melanoma and other cancers.

Virginia Commonwealth University Institute of Molecular Medicine and VCU Massey Cancer Center researchers have discovered how a gene, melanoma differentiation associated gene-9/syntenin (mda-9/syntenin), interacts with an important signaling protein to promote metastasis in human melanoma cells, a discovery that could one day lead to the development of the next generation of anti-metastatic drugs for melanoma and other cancers.

Related Articles


Metastatic disease is one of the primary challenges in cancer therapy. When cancer cells are localized in the body, specialists may be able to surgically remove the diseased area. However, when cancer metastasizes or spreads to sites remote from the primary tumor through the lymph system and blood vessels to new target sites, treatment becomes more difficult and in many instances ineffective.

Previous studies have shown that mda-9/syntenin regulates cell motility and can alter certain biochemical and signaling pathways leading to acquisition of metastatic ability. However, the exact mechanisms involved with these processes have not been well understood until now.

In the study, published online the week of Sept. 29 in the Early Edition of the Proceedings of the National Academy of Sciences, researchers report on the molecular mechanisms by which mda-9/syntenin is able to mediate invasion, migration, anchorage-independent growth and metastasis by physically interacting with c-Src, a key signaling protein involved with tumor cell growth and metastasis.

The team examined human cancer cells in the laboratory using a relevant human melanoma metastasis model and discovered how mda-9/syntenin was able to activate, or switch-on, the expression of c-Src. The expression of c-Src led to an increase in the formation of an active FAK/c-Src signaling complex. According to the researchers, this interaction triggers a signaling cascade resulting in increased cancer cell motility, invasion and metastasis.

"Mda-9/syntenin may represent a potential new molecular target for melanoma therapy that could be used to develop therapeutic reagents for treating this cancer as well as other cancers originating in the breast and stomach," said Paul B. Fisher, M.Ph., Ph.D., professor and chair of the Department of Human and Molecular Genetics and director of the VCU Institute of Molecular Medicine in the VCU School of Medicine.

"By disrupting the interaction between mda-9/syntenin and c-Src, it may be possible to prevent metastasis by blocking those signaling changes necessary for this process," he said.

According to Fisher, using this strategy it may be possible to identify compounds that serve this function and are effective therapeutic molecules for counteracting this final and frequently lethal stage of tumor progression.

The team will conduct further investigations to determine if small molecule drugs can be identified and developed to prevent metastasis by targeting this critical interaction between mda-9/syntenin and c-Src. Further studies are also in progress to determine how general these interactions are in mediating metastasis of other human tumors in addition to melanoma.

This work was supported by grants from the National Institutes of Health, National Cancer Institute and the Samuel Waxman Cancer Research Foundation.


Story Source:

The above story is based on materials provided by Virginia Commonwealth University. Note: Materials may be edited for content and length.


Cite This Page:

Virginia Commonwealth University. "Mechanism Used By Gene To Promote Metastasis In Human Cancer Cells Identified." ScienceDaily. ScienceDaily, 1 October 2008. <www.sciencedaily.com/releases/2008/09/080929212921.htm>.
Virginia Commonwealth University. (2008, October 1). Mechanism Used By Gene To Promote Metastasis In Human Cancer Cells Identified. ScienceDaily. Retrieved October 30, 2014 from www.sciencedaily.com/releases/2008/09/080929212921.htm
Virginia Commonwealth University. "Mechanism Used By Gene To Promote Metastasis In Human Cancer Cells Identified." ScienceDaily. www.sciencedaily.com/releases/2008/09/080929212921.htm (accessed October 30, 2014).

Share This



More Health & Medicine News

Thursday, October 30, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Mind-Controlled Prosthetic Arm Restores Amputee Dexterity

Mind-Controlled Prosthetic Arm Restores Amputee Dexterity

Reuters - Innovations Video Online (Oct. 29, 2014) A Swedish amputee who became the first person to ever receive a brain controlled prosthetic arm is able to manipulate and handle delicate objects with an unprecedented level of dexterity. The device is connected directly to his bone, nerves and muscles, giving him the ability to control it with his thoughts. Matthew Stock reports. Video provided by Reuters
Powered by NewsLook.com
Google To Use Nanoparticles, Wearables To Detect Disease

Google To Use Nanoparticles, Wearables To Detect Disease

Newsy (Oct. 29, 2014) Google X wants to improve modern medicine with nanoparticles and a wearable device. It's all an attempt to tackle disease detection and prevention. Video provided by Newsy
Powered by NewsLook.com
Can Drinking Milk Lead To Early Death?

Can Drinking Milk Lead To Early Death?

Newsy (Oct. 29, 2014) Researchers in Sweden released a study showing heavy milk drinkers face an increased mortality risk from a variety of causes. Video provided by Newsy
Powered by NewsLook.com
Obama: The US Will Not 'run and Hide' From Ebola

Obama: The US Will Not 'run and Hide' From Ebola

AP (Oct. 29, 2014) Surrounded by health care workers in the White House East Room, President Barack Obama said the U.S. will likely see additional Ebola cases in the weeks ahead. But he said the nation can't seal itself off in the fight against the disease. (Oct. 29) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

    Environment News

    Technology News



    Save/Print:
    Share:

    Free Subscriptions


    Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

    Get Social & Mobile


    Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

    Have Feedback?


    Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
    Mobile: iPhone Android Web
    Follow: Facebook Twitter Google+
    Subscribe: RSS Feeds Email Newsletters
    Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins