Featured Research

from universities, journals, and other organizations

Groundbreaking Discovery May Lead To Stronger Antibiotics

Date:
October 2, 2008
Source:
University of Virginia Health System
Summary:
The last decade has seen a dramatic decline in the effectiveness of antibiotics, resulting in a mounting public health crisis across the world. A new breakthrough provides physicians and patients a potential new approach toward the creation of less resistant and more effective antibiotics.

The last decade has seen a dramatic decline in the effectiveness of antibiotics, resulting in a mounting public health crisis across the world.  A new breakthrough by University of Virginia researchers provides physicians and patients a potential new approach toward the creation of less resistant and more effective antibiotics.

Related Articles


"As bacteria become more resistant to our current classes of antibiotics, there also has been a general lack of new targets for developing novel antibiotics," says John H. Bushweller, Ph.D., who led a new study appearing in the September 26, 2008, issue of Molecular Cell.  "This is a dangerous situation, but our discovery provides a starting point for a completely novel class of antibiotics, acting via a different mechanism."

What Dr. Bushweller, professor of molecular physiology and biological physics, and fellow researchers at the UVA Health System and Harvard Medical School have determined is the structure of a particular integral membrane enzyme, called DsbB - one of the many proteins that reside in cell membranes.  These so-called integral membrane proteins are important, because they account for roughly one-third of any genome in the human body and are the targets of more than half of all currently used drugs. 

Until now, scientists have been unable to acquire much structural information about these types of proteins; yet determining a protein's structure is vital in order to understand how it functions and how it can potentially operate as a drug target.

The study led by Dr. Bushweller represents the first time scientists have cracked the code required to solve a certain class of membrane protein structure by using nuclear magnetic resonance (NMR) spectroscopy, the preeminent technique for determining the structure of organic compounds.  This novel NMR approach now gives the scientific community a brand new platform for attempting to determine structures of other important membrane proteins. 

"What this means is that not only did we establish NMR spectroscopy as a potent tool for the characterization of the structure, dynamics and function of integral membrane proteins, but we also discovered that the DsbB enzyme is an exciting potential new target agent for the creation of novel antibiotics," says Dr. Bushweller.  "This could give us the roadmap to an entirely new class of antibiotics."


Story Source:

The above story is based on materials provided by University of Virginia Health System. Note: Materials may be edited for content and length.


Cite This Page:

University of Virginia Health System. "Groundbreaking Discovery May Lead To Stronger Antibiotics." ScienceDaily. ScienceDaily, 2 October 2008. <www.sciencedaily.com/releases/2008/10/081001130008.htm>.
University of Virginia Health System. (2008, October 2). Groundbreaking Discovery May Lead To Stronger Antibiotics. ScienceDaily. Retrieved November 26, 2014 from www.sciencedaily.com/releases/2008/10/081001130008.htm
University of Virginia Health System. "Groundbreaking Discovery May Lead To Stronger Antibiotics." ScienceDaily. www.sciencedaily.com/releases/2008/10/081001130008.htm (accessed November 26, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Wednesday, November 26, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

From Popcorn To Vending Snacks: FDA Ups Calorie Count Rules

From Popcorn To Vending Snacks: FDA Ups Calorie Count Rules

Newsy (Nov. 25, 2014) — The US FDA is announcing new calorie rules on Tuesday that will require everywhere from theaters to vending machines to include calorie counts. Video provided by Newsy
Powered by NewsLook.com
Daily Serving Of Yogurt Could Reduce Risk Of Type 2 Diabetes

Daily Serving Of Yogurt Could Reduce Risk Of Type 2 Diabetes

Newsy (Nov. 25, 2014) — Need another reason to eat yogurt every day? Researchers now say it could reduce a person's risk of developing type 2 diabetes. Video provided by Newsy
Powered by NewsLook.com
Madagascar Working to Contain Plague Outbreak

Madagascar Working to Contain Plague Outbreak

AFP (Nov. 24, 2014) — Madagascar said Monday it is trying to contain an outbreak of plague -- similar to the Black Death that swept Medieval Europe -- that has killed 40 people and is spreading to the capital Antananarivo. Duration: 00:42 Video provided by AFP
Powered by NewsLook.com
Are Female Bosses More Likely To Be Depressed?

Are Female Bosses More Likely To Be Depressed?

Newsy (Nov. 24, 2014) — A new study links greater authority with increased depressive symptoms among women in the workplace. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins