Featured Research

from universities, journals, and other organizations

Proteins Involved In Blood Vessel Dysfunction In Type 2 Diabetes Are Identified

Date:
October 8, 2008
Source:
University of Missouri-Columbia
Summary:
Using precise microscopes, researchers are dissecting coronary microvessels and testing which proteins are responsible for inflammation that causes blood-vessel dysfunction. By identifying the proteins that play important roles in blood-vessel dysfunction, they hope to develop new treatments for blood-vessel dysfunction in people with type 2 diabetes.

According to the American Heart Association, three-fourths of people with diabetes die of some form of heart or blood-vessel disease. Previous studies have shown that cardiac function is compromised and cardiovascular diseases are increased in people with type 2 diabetes. Before vascular diseases develop in diabetics, blood-vessel cell dysfunction occurs.

Using precise microscopes, University of Missouri researchers are dissecting coronary microvessels and testing which proteins are responsible for inflammation that causes blood-vessel dysfunction. By identifying the proteins that play important roles in blood-vessel dysfunction, they hope to develop new treatments for blood-vessel dysfunction in people with type 2 diabetes.

“We believe that understanding blood-vessel dysfunction in diabetes is critical because the progression of vascular diseases may be significantly reduced if dysfunction is corrected,” said Cuihua Zhang, an investigator in the Dalton Cardiovascular Research Center and associate professor of internal medicine in the MU School of Medicine. “The results of our studies may provide new approaches for the treatment of blood-vessel diseases and disorders in type 2 diabetes, such as the possible use of antibodies that work to stop the proteins responsible for inflammation.”

Zhang and other researchers tested their hypothesis that tumor necrosis factor-α (TNF-α), a signaling protein involved in inflammation, was responsible for blood-vessel dysfunction in type 2 diabetes. They observed that diabetic mice had elevated levels of TNF. When diabetic mice lacked TNF, their blood vessels functioned normally. They also observed that advanced glycation end products and their receptors (AGE/RAGE), which are proteins and lipids that are thought to contribute to various blood vessel complications, amplified TNF production in diabetes. In patients with diabetes, AGEs accumulate more quickly than normal in the blood and arteries.

“We found that the overproduction of AGE and RAGE contributes to blood-vessel dysfunction in type 2 diabetes,” Zhang said. “Changes in the blood vessels caused by these proteins cause oxidative stress and vascular dysfunction that leads to diseases such as heart disease and stroke.”

Zhang presented “TNF-Alpha and Vascular Dysfunction” at Keystone Symposia Conference in Breckenridge, Colo.


Story Source:

The above story is based on materials provided by University of Missouri-Columbia. Note: Materials may be edited for content and length.


Journal Reference:

  1. AGE/RAGE Produces Endotheilial Dysfunction in Coronary Arterioles in Type II Diabetic Mice. American Journal of Physiology, (in press)

Cite This Page:

University of Missouri-Columbia. "Proteins Involved In Blood Vessel Dysfunction In Type 2 Diabetes Are Identified." ScienceDaily. ScienceDaily, 8 October 2008. <www.sciencedaily.com/releases/2008/10/081006130544.htm>.
University of Missouri-Columbia. (2008, October 8). Proteins Involved In Blood Vessel Dysfunction In Type 2 Diabetes Are Identified. ScienceDaily. Retrieved July 30, 2014 from www.sciencedaily.com/releases/2008/10/081006130544.htm
University of Missouri-Columbia. "Proteins Involved In Blood Vessel Dysfunction In Type 2 Diabetes Are Identified." ScienceDaily. www.sciencedaily.com/releases/2008/10/081006130544.htm (accessed July 30, 2014).

Share This




More Health & Medicine News

Wednesday, July 30, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Health Insurers' Profits Slide

Health Insurers' Profits Slide

Reuters - Business Video Online (July 30, 2014) Obamacare-related costs were said to be behind the profit plunge at Wellpoint and Humana, but Wellpoint sees the new exchanges boosting its earnings for the full year. Fred Katayama reports. Video provided by Reuters
Powered by NewsLook.com
Concern Grows Over Worsening Ebola Crisis

Concern Grows Over Worsening Ebola Crisis

AFP (July 30, 2014) Pan-African airline ASKY has suspended all flights to and from the capitals of Liberia and Sierra Leone amid the worsening Ebola health crisis, which has so far caused 672 deaths in Guinea, Liberia and Sierra Leone. Duration: 00:43 Video provided by AFP
Powered by NewsLook.com
At Least 20 Chikungunya Cases in New Jersey

At Least 20 Chikungunya Cases in New Jersey

AP (July 30, 2014) At least 20 New Jersey residents have tested positive for chikungunya, a mosquito-borne virus that has spread through the Caribbean. (July 30) Video provided by AP
Powered by NewsLook.com
Generics Eat Into Pfizer's Sales

Generics Eat Into Pfizer's Sales

Reuters - Business Video Online (July 29, 2014) Pfizer, the world's largest drug maker, cut full-year revenue forecasts because generics could cut into sales of its anti-arthritis drug, Celebrex. Fred Katayama reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins