Featured Research

from universities, journals, and other organizations

Mechanism Of Asymmetry In Meiotic Cell Division Probed

Date:
October 13, 2008
Source:
Stowers Institute for Medical Research
Summary:
Scientists have characterized a mechanism that allows for asymmetrical cell division during meiosis in oocytes. By tracking chromosome movement in live mouse oocytes, they have discovered that chromosomes can recruit to their vicinity a protein called formin-2. This protein allows the oocyte to retain the majority of the cytoplasm -- a requirement for embryonic development after fertilization -- while the other daughter cell (called a polar body) resulting from the asymmetric division gets only a minimal amount and subsequently dies.

The Stowers Institute's Rong Li Lab has characterized a mechanism that allows for asymmetrical cell division during meiosis in oocytes. By tracking chromosome movement in live mouse oocytes, the team discovered that chromosomes can recruit to their vicinity a protein called formin-2.

Related Articles


This protein allows the oocyte to retain the majority of the cytoplasm – a requirement for embryonic development after fertilization – while the other daughter cell (called a polar body) resulting from the asymmetric division gets only a minimal amount and subsequently dies.

The work was recently published in the advance online publication of Nature Cell Biology.

Formin-2 is an actin-nucleating protein that can promote the formation of actin filaments around the chromosomes. Actin filaments undergo dynamic elongation and shortening and, in the process, push the chromosomes towards the outer edge of the oocyte. After the chromosomes reach the periphery, the actin filaments orient the cell division plane so that most of the cytoplasm required to sustain the earliest stages of development stays with the daughter cell that retains the identy of the oocyte.

"This work revealed the general mechanism by which the actin cytoskeleton drives chromosome movement in mammalian meiotic oocytes," said Hongbin Li, Ph.D., Senior Research Associate and lead author on the publication. "Our findings will enable us to carry out even more detailed dissection of the molecular components and mechanisms."

"Infertility and birth defects are often related to problems during oocyte meiotic cell divisions," said Rong Li, Ph.D., Investigator and senior author on the paper. "Failure in the chromosome movement will lead to failed oocyte maturation and infertility. These findings provide an important step toward a better understanding of the process of meiotic divisions and how actin generates the force to power intra-cellular movements."

The work is the result of a collaboration with Stowers Institute's Fengli Guo, Ph.D., Electron Microscopy Specialist, and Boris Rubinstein, Ph.D., Biomathematician, who are co-authors on the paper.


Story Source:

The above story is based on materials provided by Stowers Institute for Medical Research. Note: Materials may be edited for content and length.


Cite This Page:

Stowers Institute for Medical Research. "Mechanism Of Asymmetry In Meiotic Cell Division Probed." ScienceDaily. ScienceDaily, 13 October 2008. <www.sciencedaily.com/releases/2008/10/081007120421.htm>.
Stowers Institute for Medical Research. (2008, October 13). Mechanism Of Asymmetry In Meiotic Cell Division Probed. ScienceDaily. Retrieved November 28, 2014 from www.sciencedaily.com/releases/2008/10/081007120421.htm
Stowers Institute for Medical Research. "Mechanism Of Asymmetry In Meiotic Cell Division Probed." ScienceDaily. www.sciencedaily.com/releases/2008/10/081007120421.htm (accessed November 28, 2014).

Share This


More From ScienceDaily



More Plants & Animals News

Friday, November 28, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

New Dinosaur Species Found in Museum Collection

New Dinosaur Species Found in Museum Collection

Reuters - Innovations Video Online (Nov. 27, 2014) A British palaeontologist has discovered a new species of dinosaur while studying fossils in a Canadian museum. Pentaceratops aquilonius was related to Triceratops and lived at the end of the Cretaceous Period, around 75 million years ago. Jim Drury has more. Video provided by Reuters
Powered by NewsLook.com
Classic Hollywood Memorabilia Goes Under the Hammer

Classic Hollywood Memorabilia Goes Under the Hammer

Reuters - Entertainment Video Online (Nov. 26, 2014) The iconic piano from "Casablanca" and the Cowardly Lion suit from "The Wizard of Oz" fetch millions at auction. Sara Hemrajani reports. Video provided by Reuters
Powered by NewsLook.com
Pet Dogs to Be Used in Anti-Ageing Trial

Pet Dogs to Be Used in Anti-Ageing Trial

Reuters - Innovations Video Online (Nov. 26, 2014) Researchers in the United States are preparing to discover whether a drug commonly used in human organ transplants can extend the lifespan and health quality of pet dogs. Video provided by Reuters
Powered by NewsLook.com
From Popcorn To Vending Snacks: FDA Ups Calorie Count Rules

From Popcorn To Vending Snacks: FDA Ups Calorie Count Rules

Newsy (Nov. 25, 2014) The US FDA is announcing new calorie rules on Tuesday that will require everywhere from theaters to vending machines to include calorie counts. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Plants & Animals

Earth & Climate

Fossils & Ruins

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins