Featured Research

from universities, journals, and other organizations

New Risk Factor For Prostate Cancer

Date:
October 14, 2008
Source:
University of Oxford
Summary:
The greater the levels of a protein called Insulin-like Growth Factor-1 (IGF-1), the greater the risk of prostate cancer, a new study has found.

The greater the levels of a protein called Insulin-like Growth Factor-1 (IGF-1), the greater the risk of prostate cancer, an Oxford University-led study has found.

IGF-1 levels are influenced by lifestyle factors such as diet, so the study could help in tailoring the advice given to men at high risk of developing prostate cancer.

An international team of researchers, funded by Cancer Research UK, analysed data from 12 previous independent studies on the relationship between blood concentrations of suspected prostate cancer risk factors, and subsequent onset of the disease.

Previously, some but not all studies had suggested a link between IGF-1 levels and increased risk of developing the disease.

‘There is a need to identify risk factors for prostate cancer, especially those which can be targeted by therapy and/or lifestyle changes,’ says lead author Dr Andrew Roddam of the Cancer Epidemiology Unit at the University of Oxford. ‘Now we know this factor is associated with the disease we can start to examine how diet and lifestyle factors can affect its levels and whether changes could reduce a man’s risk.’

Prostate cancer is the most common cancer in men in the UK, accounting for a quarter of all new cases of cancer diagnosed in men. More than 34,000 men in the UK are diagnosed with prostate cancer each year. The disease causes around 10,000 deaths a year and is the second most common cause of cancer death in UK men after lung cancer. 

‘It is important to point out that there is no evidence to suggest that measurement of IGF-1 levels could be used to develop new prostate screening methods,’ adds Dr Roddam. ‘Other studies have shown that existing methods of detecting prostate cancer are not improved by also measuring IGF levels.’

The scientists looked at the data collected from blood samples of 3,700 men with prostate cancer and 5,200 men without the disease. The research found that men with higher levels of IGF-1 were more likely to go on to develop prostate cancer than those with lower levels of the protein.

‘While there are established risk factors associated with prostate cancer of age, family and ethnicity, there are no clear data on modifiable risk factors,’ says Dr Lesley Walker, Cancer Research UK’s director of cancer information.

‘Research like this is vital to further the work on prevention and treatment of the disease. The findings are also likely to be of interest to scientists who are looking at developing drugs to prevent prostate cancer.’

Due to the nature of the data collected for this collaboration, it is not possible to calculate an individual risk of prostate cancer. However, the results are important as they help in the understanding of the causes of prostate cancer.


Story Source:

The above story is based on materials provided by University of Oxford. Note: Materials may be edited for content and length.


Journal Reference:

  1. A. W. Roddam, N. E. Allen, P. Appleby, T. J. Key, L. Ferrucci, H. B. Carter, E. J. Metter, C. Chen, N. S. Weiss, A. Fitzpatrick, A. W. Hsing, J. V. Lacey, Jr, K. Helzlsouer, S. Rinaldi, E. Riboli, R. Kaaks, J. A.M.J.L. Janssen, M. F. Wildhagen, F. H. Schrφder, E. A. Platz, M. Pollak, E. Giovannucci, C. Schaefer, C. P. Quesenberry, Jr., J. H. Vogelman, G. Severi, D. R. English, G. G. Giles, P. Stattin, G. Hallmans, M. Johansson, J. M. Chan, P. Gann, S. E. Oliver, J. M. Holly, J. Donovan, F. Meyer, I. Bairati and P. Galan. Insulin-like Growth Factors, Their Binding Proteins, and Prostate Cancer Risk: Analysis of Individual Patient Data from 12 Prospective Studies. Ann Intern Med, 2008; 461-471 [link]

Cite This Page:

University of Oxford. "New Risk Factor For Prostate Cancer." ScienceDaily. ScienceDaily, 14 October 2008. <www.sciencedaily.com/releases/2008/10/081012094307.htm>.
University of Oxford. (2008, October 14). New Risk Factor For Prostate Cancer. ScienceDaily. Retrieved July 23, 2014 from www.sciencedaily.com/releases/2008/10/081012094307.htm
University of Oxford. "New Risk Factor For Prostate Cancer." ScienceDaily. www.sciencedaily.com/releases/2008/10/081012094307.htm (accessed July 23, 2014).

Share This




More Health & Medicine News

Wednesday, July 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Courts Conflicted Over Healthcare Law

Courts Conflicted Over Healthcare Law

AP (July 22, 2014) — Two federal appeals courts issued conflicting rulings Tuesday on the legality of the federally-run healthcare exchange that operates in 36 states. (July 22) Video provided by AP
Powered by NewsLook.com
Why Do People Believe We Only Use 10 Percent Of Our Brains?

Why Do People Believe We Only Use 10 Percent Of Our Brains?

Newsy (July 22, 2014) — The new sci-fi thriller "Lucy" is making people question whether we really use all our brainpower. But, as scientists have insisted for years, we do. Video provided by Newsy
Powered by NewsLook.com
Scientists Find New Way To Make Human Platelets

Scientists Find New Way To Make Human Platelets

Newsy (July 22, 2014) — Boston scientists have discovered a new way to create fully functioning human platelets using a bioreactor and human stem cells. Video provided by Newsy
Powered by NewsLook.com
Gilead's $1000-a-Pill Drug Could Cure Hep C in HIV-Positive People

Gilead's $1000-a-Pill Drug Could Cure Hep C in HIV-Positive People

TheStreet (July 21, 2014) — New research shows Gilead Science's drug Sovaldi helps in curing hepatitis C in those who suffer from HIV. In a medical study, the combination of Gilead's Hep C drug with anti-viral drug Ribavirin cured 76% of HIV-positive patients suffering from the most common hepatitis C strain. Hepatitis C and related complications have been a top cause of death in HIV-positive patients. Typical medication used to treat the disease, including interferon proteins, tended to react badly with HIV drugs. However, Sovaldi's %1,000-a-pill price tag could limit the number of patients able to access the treatment. TheStreet's Keris Lahiff reports from New York. Video provided by TheStreet
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins