Featured Research

from universities, journals, and other organizations

Knocking The 'Sox' Off Cancer And Lymphatic Disorders

Date:
October 24, 2008
Source:
The University of Queensland
Summary:
Researchers have identified a gene critical for the development of the lymphatic system in a discovery that will have implications for treatment of cancer and lymphatic disorders and other diseases.

Researchers have identified a gene critical for the development of the lymphatic system in a discovery that will have implications for treatment of cancer and lymphatic disorders and other diseases.

Related Articles


The team, led by Professor Peter Koopman and Dr Mathias Franηois from the Institute for Molecular Bioscience at The University of Queensland (UQ), found that a single gene - Sox18 - triggers the development of the lymphatic vessels.

"The rate at which new lymphatic vessels can form is thought to be one of the key factors in determining how quickly a tumour can spread and thus how severely a patient will be affected by cancer," Professor Koopman said.

"The lymphatic vessels also play a central role in maintaining fluid balance in the body and carrying infection-fighting white blood cells, so greater knowledge about the lymphatic system can offer insights and suggest therapies for a range of diseases."

The team made the discovery, reported today (Monday, October 20) in leading science journal Nature, by examining mice in which Sox18 had been inactivated. They found that the development of lymphatic vessels was massively disrupted.

"We suspected Sox18 might play a critical role in lymphatic vessel formation after observing that mice with one inactivated copy of the gene displayed similar symptoms to humans with a genetic condition that affects the lymphatic system, known as HLT," Professor Koopman said.

"It turns out that Sox18 has a much more important role than we first thought – in fact, it's the master controller of lymphatic vessel development."

The team will now focus on finding genes regulated by Sox18 and determining how this regulation occurs, which may suggest ways of promoting or preventing lymphatic vessel formation.

"If we know how to prevent lymphatic vessels from forming, then we will be a lot closer to halting the spread of tumours through the body. Conversely, if we know how to stimulate the formation of these vessels, then it might be possible to treat diseases such as lymphedema," Professor Koopman said.

Lymphedema occurs when the lymphatic vasculature is impaired, causing a build-up of fluid in part of the body, which leads to painful and dangerous swelling of that body part, and, if left untreated, deformity.

The discovery was the result of three years of research by an international team of scientists from Australia, Italy and Hong Kong, led by UQ and supported by a number of organisations including the Australian Cancer Research Foundation, the National Health and Medical Research Council of Australia, the Heart Foundation of Australia, and the Australian Research Council.


Story Source:

The above story is based on materials provided by The University of Queensland. Note: Materials may be edited for content and length.


Cite This Page:

The University of Queensland. "Knocking The 'Sox' Off Cancer And Lymphatic Disorders." ScienceDaily. ScienceDaily, 24 October 2008. <www.sciencedaily.com/releases/2008/10/081020093504.htm>.
The University of Queensland. (2008, October 24). Knocking The 'Sox' Off Cancer And Lymphatic Disorders. ScienceDaily. Retrieved March 28, 2015 from www.sciencedaily.com/releases/2008/10/081020093504.htm
The University of Queensland. "Knocking The 'Sox' Off Cancer And Lymphatic Disorders." ScienceDaily. www.sciencedaily.com/releases/2008/10/081020093504.htm (accessed March 28, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Saturday, March 28, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

These Popular Antibiotics Can Cause Permanent Nerve Damage

These Popular Antibiotics Can Cause Permanent Nerve Damage

Newsy (Mar. 27, 2015) — A popular class of antibiotic can leave patients in severe pain and even result in permanent nerve damage. Video provided by Newsy
Powered by NewsLook.com
House Ready to Pass Medicare Doc Bill

House Ready to Pass Medicare Doc Bill

AP (Mar. 26, 2015) — In rare bipartisan harmony, congressional leaders pushed a $214 billion bill permanently blocking physician Medicare cuts toward House passage Thursday, moving lawmakers closer to resolving a problem that has plagued them for years. (March 26) Video provided by AP
Powered by NewsLook.com
What's Different About This Latest Ebola Vaccine

What's Different About This Latest Ebola Vaccine

Newsy (Mar. 26, 2015) — A whole virus Ebola vaccine has been shown to protect monkeys exposed to the virus. Here&apos;s what&apos;s different about this vaccine. Video provided by Newsy
Powered by NewsLook.com
HIV Outbreak Prompts Public Health Emergency In Indiana

HIV Outbreak Prompts Public Health Emergency In Indiana

Newsy (Mar. 26, 2015) — Indiana Gov. Mike Pence says he will bring additional state resources to help stop the epidemic. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins