Featured Research

from universities, journals, and other organizations

Knocking The 'Sox' Off Cancer And Lymphatic Disorders

Date:
October 24, 2008
Source:
The University of Queensland
Summary:
Researchers have identified a gene critical for the development of the lymphatic system in a discovery that will have implications for treatment of cancer and lymphatic disorders and other diseases.

Researchers have identified a gene critical for the development of the lymphatic system in a discovery that will have implications for treatment of cancer and lymphatic disorders and other diseases.

The team, led by Professor Peter Koopman and Dr Mathias Franηois from the Institute for Molecular Bioscience at The University of Queensland (UQ), found that a single gene - Sox18 - triggers the development of the lymphatic vessels.

"The rate at which new lymphatic vessels can form is thought to be one of the key factors in determining how quickly a tumour can spread and thus how severely a patient will be affected by cancer," Professor Koopman said.

"The lymphatic vessels also play a central role in maintaining fluid balance in the body and carrying infection-fighting white blood cells, so greater knowledge about the lymphatic system can offer insights and suggest therapies for a range of diseases."

The team made the discovery, reported today (Monday, October 20) in leading science journal Nature, by examining mice in which Sox18 had been inactivated. They found that the development of lymphatic vessels was massively disrupted.

"We suspected Sox18 might play a critical role in lymphatic vessel formation after observing that mice with one inactivated copy of the gene displayed similar symptoms to humans with a genetic condition that affects the lymphatic system, known as HLT," Professor Koopman said.

"It turns out that Sox18 has a much more important role than we first thought – in fact, it's the master controller of lymphatic vessel development."

The team will now focus on finding genes regulated by Sox18 and determining how this regulation occurs, which may suggest ways of promoting or preventing lymphatic vessel formation.

"If we know how to prevent lymphatic vessels from forming, then we will be a lot closer to halting the spread of tumours through the body. Conversely, if we know how to stimulate the formation of these vessels, then it might be possible to treat diseases such as lymphedema," Professor Koopman said.

Lymphedema occurs when the lymphatic vasculature is impaired, causing a build-up of fluid in part of the body, which leads to painful and dangerous swelling of that body part, and, if left untreated, deformity.

The discovery was the result of three years of research by an international team of scientists from Australia, Italy and Hong Kong, led by UQ and supported by a number of organisations including the Australian Cancer Research Foundation, the National Health and Medical Research Council of Australia, the Heart Foundation of Australia, and the Australian Research Council.


Story Source:

The above story is based on materials provided by The University of Queensland. Note: Materials may be edited for content and length.


Cite This Page:

The University of Queensland. "Knocking The 'Sox' Off Cancer And Lymphatic Disorders." ScienceDaily. ScienceDaily, 24 October 2008. <www.sciencedaily.com/releases/2008/10/081020093504.htm>.
The University of Queensland. (2008, October 24). Knocking The 'Sox' Off Cancer And Lymphatic Disorders. ScienceDaily. Retrieved July 31, 2014 from www.sciencedaily.com/releases/2008/10/081020093504.htm
The University of Queensland. "Knocking The 'Sox' Off Cancer And Lymphatic Disorders." ScienceDaily. www.sciencedaily.com/releases/2008/10/081020093504.htm (accessed July 31, 2014).

Share This




More Health & Medicine News

Thursday, July 31, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Health Insurers' Profits Slide

Health Insurers' Profits Slide

Reuters - Business Video Online (July 30, 2014) — Obamacare-related costs were said to be behind the profit plunge at Wellpoint and Humana, but Wellpoint sees the new exchanges boosting its earnings for the full year. Fred Katayama reports. Video provided by Reuters
Powered by NewsLook.com
Peace Corps Pulls Workers From W. Africa Over Ebola Fears

Peace Corps Pulls Workers From W. Africa Over Ebola Fears

Newsy (July 30, 2014) — The Peace Corps is one of several U.S.-based organizations to pull workers out of West Africa because of the Ebola outbreak. Video provided by Newsy
Powered by NewsLook.com
Weather Kills 2K A Year, But Storms Aren't The Main Offender

Weather Kills 2K A Year, But Storms Aren't The Main Offender

Newsy (July 30, 2014) — Health officials say 2,000 deaths occur each year in the U.S. due to weather, but it's excessive heat and cold that claim the most lives. Video provided by Newsy
Powered by NewsLook.com
Concern Grows Over Worsening Ebola Crisis

Concern Grows Over Worsening Ebola Crisis

AFP (July 30, 2014) — Pan-African airline ASKY has suspended all flights to and from the capitals of Liberia and Sierra Leone amid the worsening Ebola health crisis, which has so far caused 672 deaths in Guinea, Liberia and Sierra Leone. Duration: 00:43 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

    Environment News

    Technology News



    Save/Print:
    Share:  

    Free Subscriptions


    Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

    Get Social & Mobile


    Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

    Have Feedback?


    Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
    Mobile iPhone Android Web
    Follow Facebook Twitter Google+
    Subscribe RSS Feeds Email Newsletters
    Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins