Featured Research

from universities, journals, and other organizations

What Makes An Axon An Axon?

Date:
November 19, 2008
Source:
Rockefeller University Press
Summary:
Inside every axon is a dendrite waiting to get out. Scientists converted mature axons into dendrites by banishing a protein crucial for neuron development. The results suggest that this transformation could occur after nerve cell damage.

Inside every axon is a dendrite waiting to get out. Hedstrom et al. converted mature axons into dendrites by banishing a protein crucial for neuron development. The results suggest that this transformation could occur after nerve cell damage.

Related Articles


At the junction between the axon and the cell body is the axon initial segment (AIS), which sparks action potentials. Researchers also suspect that the AIS enables an axon to maintain its identity. Although scientists have teased out some of the molecular events that determine whether a neuron outgrowth will become an axon or a dendrite, they know little about what keeps these structures distinct.

In cultured neurons, Hedstrom et al. used RNAi to cut production of ankyrinG, a protein that helps spur formation of the AIS. Loss of ankyrinG caused the AIS to disappear. For example, sodium channels that normally crowd the AIS's plasma membrane dispersed. When ankyrinG was absent the erstwhile axons began to resemble dendrites, sprouting spines and developing excitatory synapses. Characteristic molecules from the cell body and dendrites, such as the microtubule polymerizing protein MAP2, also infiltrated the axons.

The AIS appears to serve as a filter that screens out dendritic proteins, Hedstrom et al. conclude. How the structure bars some proteins from the axon is still uncertain. Injuries and diseases can transform dendrites into axons. The findings raise the possibility that these insults could cause the reverse transformation by changing the amount of ankyrinG and altering the AIS.

Journal reference: Hedstrom, K.L., et al. 2008. J. Cell Biol. Nov. 17, 2008 doi:10.1083/jcb.200806112.


Story Source:

The above story is based on materials provided by Rockefeller University Press. Note: Materials may be edited for content and length.


Cite This Page:

Rockefeller University Press. "What Makes An Axon An Axon?." ScienceDaily. ScienceDaily, 19 November 2008. <www.sciencedaily.com/releases/2008/11/081110112055.htm>.
Rockefeller University Press. (2008, November 19). What Makes An Axon An Axon?. ScienceDaily. Retrieved December 21, 2014 from www.sciencedaily.com/releases/2008/11/081110112055.htm
Rockefeller University Press. "What Makes An Axon An Axon?." ScienceDaily. www.sciencedaily.com/releases/2008/11/081110112055.htm (accessed December 21, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Sunday, December 21, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

The Best Tips to Curb Holiday Carbs

The Best Tips to Curb Holiday Carbs

Buzz60 (Dec. 19, 2014) It's hard to resist those delicious but fattening carbs we all crave during the winter months, but there are some ways to stay satisfied without consuming the extra calories. Vanessa Freeman (@VanessaFreeTV) has the details. Video provided by Buzz60
Powered by NewsLook.com
Sierra Leone Bikers Spread the Message to Fight Ebola

Sierra Leone Bikers Spread the Message to Fight Ebola

AFP (Dec. 19, 2014) More than 100 motorcyclists hit the road to spread awareness messages about Ebola. Nearly 7,000 people have now died from the virus, almost all of them in west Africa, according to the World Health Organization. Video provided by AFP
Powered by NewsLook.com
Researchers Test Colombian Village With High Alzheimer's Rates

Researchers Test Colombian Village With High Alzheimer's Rates

AFP (Dec. 19, 2014) In Yarumal, a village in N. Colombia, Alzheimer's has ravaged a disproportionately large number of families. A genetic "curse" that may pave the way for research on how to treat the disease that claims a new victim every four seconds. Duration: 02:42 Video provided by AFP
Powered by NewsLook.com
The Best Protein-Filled Foods to Energize You for the New Year

The Best Protein-Filled Foods to Energize You for the New Year

Buzz60 (Dec. 19, 2014) The new year is coming and nothing will energize you more for 2015 than protein-filled foods. Fitness and nutrition expert John Basedow (@JohnBasedow) gives his favorite high protein foods that will help you build muscle, lose fat and have endless energy. Video provided by Buzz60
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins