Featured Research

from universities, journals, and other organizations

Pharmaceutical Testing: Test Identifies Toxic Platinum And Palladium Without Time-consuming Sample Pretreatment

Date:
November 24, 2008
Source:
University of Pittsburgh
Summary:
The painstaking process of detecting toxic species of platinum and palladium mixed in with the form of platinum essential to certain pharmaceuticals could be reduced to one simple step, researchers report.

The painstaking process of detecting toxic species of platinum and palladium mixed in with the form of platinum essential to certain pharmaceuticals could be reduced to one simple step, University of Pittsburgh researchers report in the “Journal of the American Chemical Society” (“JACS”).

Related Articles


A fluorogenic solution developed in the laboratory of Kazunori Koide (Ko-ee-deh), a chemistry professor in Pitt's School of Arts and Sciences, glows bright green when it comes in contact with the poisonous forms of palladium and platinum known as Pd(II) and Pt(IV), respectively. These two elements are typically broken down into the platinum species Pt(0), which is used in medications to suppress various reactive oxygen species responsible for inflammation and other maladies. But residual amounts of Pd(II) and, particularly, the more toxic Pt(IV) can remain and pose a health risk.

To root out Pd(II) and Pt(IV) requires the removal of other metals and impurities before testing. Koide's method provides a fast, easy, and inexpensive alternative, he said. Moreover, current analysis cannot detect Pt(IV) in Pt(0) samples at levels below 2,000 parts per million, Koide said. His technique can indicate Pt(IV) content as low as 2 parts per million.

“Our method does not require any pretreatment,” Koide said. “Just add the solution to the sample. Our technique detects even minute traces of toxic palladium and platinum in hours instead of days. It could reduce pharmaceutical development time by weeks and help in making a safer product.”

Koide began this project after a major pharmaceutical company contacted him about research he published in “JACS” in 2007 regarding a fluorogenic indicator for detecting palladium/platinum deposits in soil samples. It relied on a colorless fluorescein-based solution that-when exposed to blue light-glows green when it comes in contact with palladium, which coexists with platinum in nature. The Pd(II)/Pt(IV) detector involves the same fluorogenic solution used in a different way.


Story Source:

The above story is based on materials provided by University of Pittsburgh. Note: Materials may be edited for content and length.


Journal Reference:

  1. Garner et al. Oxidation State-Specific Fluorescent Method for Palladium(II) and Platinum(IV) Based on the Catalyzed Aromatic Claisen Rearrangement. Journal of the American Chemical Society, 2008; DOI: 10.1021/ja8065539

Cite This Page:

University of Pittsburgh. "Pharmaceutical Testing: Test Identifies Toxic Platinum And Palladium Without Time-consuming Sample Pretreatment." ScienceDaily. ScienceDaily, 24 November 2008. <www.sciencedaily.com/releases/2008/11/081114184628.htm>.
University of Pittsburgh. (2008, November 24). Pharmaceutical Testing: Test Identifies Toxic Platinum And Palladium Without Time-consuming Sample Pretreatment. ScienceDaily. Retrieved November 21, 2014 from www.sciencedaily.com/releases/2008/11/081114184628.htm
University of Pittsburgh. "Pharmaceutical Testing: Test Identifies Toxic Platinum And Palladium Without Time-consuming Sample Pretreatment." ScienceDaily. www.sciencedaily.com/releases/2008/11/081114184628.htm (accessed November 21, 2014).

Share This


More From ScienceDaily



More Matter & Energy News

Friday, November 21, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

NSA Director: China Can Damage US Power Grid

NSA Director: China Can Damage US Power Grid

AP (Nov. 20, 2014) China and "one or two" other countries are capable of mounting cyberattacks that would shut down the electric grid and other critical systems in parts of the United States, according to Adm. Michael Rogers, director of the National Security Agency and hea Video provided by AP
Powered by NewsLook.com
Latest Minivan Crash Tests Aren't Pretty

Latest Minivan Crash Tests Aren't Pretty

Newsy (Nov. 20, 2014) Five minivans were put to the test in head-on crash simulations by the Insurance Institute for Highway Safety. Video provided by Newsy
Powered by NewsLook.com
Takata Offers "sincerest Condolences" To Victims of Malfunctioning Airbag

Takata Offers "sincerest Condolences" To Victims of Malfunctioning Airbag

Reuters - US Online Video (Nov. 20, 2014) U.S. Congress hears from a victim and company officials as it holds a hearing on the safety of Takata airbags after reports of injuries. Rough Cut (no reporter narration). Video provided by Reuters
Powered by NewsLook.com
DARPA Creates The Tech You Can Only Dream Of

DARPA Creates The Tech You Can Only Dream Of

Newsy (Nov. 20, 2014) Curious what a rocket-dodging car would look like? How about a robotic pack mule? Or maybe a wearable robot? These are a few of DARPA's projects. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Space & Time

Matter & Energy

Computers & Math

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins