Featured Research

from universities, journals, and other organizations

Urine Protein Test Detects Kidney Dysfunction In Transplant Patients

Date:
November 26, 2008
Source:
American Society of Nephrology
Summary:
A noninvasive test that analyzes proteins in the urine can correctly identify patients whose transplanted kidneys are failing, according to a study appearing in the February 2009 issue of the Journal of the American Society Nephrology. The results might allow physicians to more accurately monitor transplant patients and to fine-tune the immunosuppressive therapies prescribed to prevent kidney rejection.

 A noninvasive test that analyzes proteins in the urine can correctly identify patients whose transplanted kidneys are failing, according to a new study. The results might allow physicians to more accurately monitor transplant patients and to fine-tune the immunosuppressive therapies prescribed to prevent kidney rejection. 

Related Articles


While kidney transplantation is the treatment of choice for patients with end-stage renal disease, more than 50 percent of transplants fail over time. This may be because of defects that arise within the kidney or because the kidney is rejected by the recipient’s immune system. As examples, patients may develop conditions called interstitial fibrosis and tubular atrophy or chronic antibody-mediated rejection.

These two conditions can both lead to kidney dysfunction, but they have very different characteristics and outcomes.

Currently, it is difficult to detect the early stages of kidney dysfunction following transplantation, and detection techniques require invasive biopsies. However, new analytical tools that screen for proteins in body fluids are becoming useful for indicating the presence of various medical conditions. Luis Quintana, MD, of Servicio de Nefrologνa y Trasplante Renal, Hospital Clinic, in Barcelona, Spain and his colleagues set out to see if this type of screening technique might be applied to the detection of conditions related to kidney dysfunction.

The investigators studied 50 individuals: 14 patients with interstitial fibrosis and tubular atrophy, 18 patients with chronic antibody-mediated rejection, eight stable kidney transplant recipients, and 10 healthy individuals. They measured various proteins in the urine of these individuals with a laboratory technique called mass spectrometry. 

The researchers found significant differences in the urine protein profiles of individuals from the various groups. Importantly, based on 14 different proteins, they were able to correctly identify 100 percent of the patients with interstitial fibrosis and tubular atrophy and 100 percent of the patients with chronic antibody-mediated rejection. “Urine proteomic analysis detected differences among healthy individuals, stable transplant recipients, patients with interstitial fibrosis and tubular atrophy, and chronic antibody-mediated rejection, showing an excellent clinical correlation,” the authors wrote.

While additional, larger studies are needed to confirm these results, the findings could have great clinical value. For example, urine protein analyses might be combined with kidney biopsies at different times after transplantation to reveal the mechanisms involved in the development of kidney dysfunction in individual patients. This information could be very helpful not only for an early diagnosis of kidney dysfunction but also for its treatment and prevention.


Story Source:

The above story is based on materials provided by American Society of Nephrology. Note: Materials may be edited for content and length.


Journal Reference:

  1. Urine Proteomics Profiling as an Initial Approach to Detect Biomarkers in Chronic Allograft Dysfunction. Journal of the American Society Nephrology, Online November 26, 2008; Print edition February 2009

Cite This Page:

American Society of Nephrology. "Urine Protein Test Detects Kidney Dysfunction In Transplant Patients." ScienceDaily. ScienceDaily, 26 November 2008. <www.sciencedaily.com/releases/2008/11/081126215256.htm>.
American Society of Nephrology. (2008, November 26). Urine Protein Test Detects Kidney Dysfunction In Transplant Patients. ScienceDaily. Retrieved January 28, 2015 from www.sciencedaily.com/releases/2008/11/081126215256.htm
American Society of Nephrology. "Urine Protein Test Detects Kidney Dysfunction In Transplant Patients." ScienceDaily. www.sciencedaily.com/releases/2008/11/081126215256.htm (accessed January 28, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Wednesday, January 28, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Poultry Culled in Taiwan to Thwart Bird Flu

Poultry Culled in Taiwan to Thwart Bird Flu

Reuters - News Video Online (Jan. 28, 2015) — Taiwan culls over a million poultry in efforts to halt various strains of avian flu. Julie Noce reports. Video provided by Reuters
Powered by NewsLook.com
Shark Bite Victim Making Amazing Recovery

Shark Bite Victim Making Amazing Recovery

AP (Jan. 27, 2015) — A Texas woman who lost more than five pounds of flesh to a shark in the Bahamas earlier this month could be released from a Florida hospital soon. Experts believe she was bitten by a bull shark while snorkeling. (Jan. 27) Video provided by AP
Powered by NewsLook.com
Shoveling Snow: How to Prevent Back Injuries

Shoveling Snow: How to Prevent Back Injuries

Washington Post (Jan. 26, 2015) — What&apos;s the proper technique for shoveling snow? A physical therapist offers specific tips for protecting your back while you dig out this winter. Video provided by Washington Post
Powered by NewsLook.com
Ebola Mistakes Should Serve a Lesson Says WHO

Ebola Mistakes Should Serve a Lesson Says WHO

AFP (Jan. 25, 2015) — The World Health Organization&apos;s chief on Sunday admitted the UN agency had been caught napping on Ebola, saying it should serve a lesson to avoid similar mistakes in future. Duration: 00:55 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins