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Gene Associated With Age-related Hearing Loss Identified

Date:
December 3, 2008
Source:
The Translational Genomics Research Institute
Summary:
Researchers discovered a common variant in the GRM7 gene, which they believe may be associated with susceptibility to glutamate excitotoxicity and hearing loss.
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Presbycusis, or age-related hearing loss, accounts for 30 percent of all hearing loss. So, why do some people lose their hearing as they get older but other people can still hear a pin drop?

"This is the first ever and largest genome-wide association study for age-related hearing loss," said Rick Friedman, M.D., Ph.D., lead author and House Ear Institute principal investigator and surgeon at the House Clinic.

The study was conducted in collaboration with colleagues at the Phoenix-based Translational Genomics Research Institute (TGen), Affymetrix in Santa Clara, Calif., and the University of Antwerp, Belgium. It uncovered several genes, but one gene stands out and is believed to put people at risk for hearing loss as they age.

They discovered a common variant in the GRM7 gene, which the research team believes may be associated with susceptibility to glutamate excitotoxicity and hearing loss.

It is the overexpression of glutamate that causes damage to the inner and outer hair cells in the inner ear leading to age-related hearing loss.

"Finding the genetic causes of age-related hearing loss could lead to treatments that would bring relief to millions of people worldwide who now suffer from social isolation, depression and even cognitive impairment as a result of not being able to properly understand what others are saying,'' said Dr. Matthew Huentelman, an investigator in TGen's Neurogenomics Division and one of the lead authors.

Researchers believe this paper's findings represent important and significant progress in the efforts to discover the origins of presbycusis.

"We have known for a long time that genes play an important role in presbycusis, but until now genetic research has lagged behind compared to other important diseases," said Guy Van Camp, director of the Hereditary Deafness Laboratory and professor, University of Antwerp, Belgium. "The identification of GRM7 is a very exciting result, as it may provide insights in the development of the disease."

The study participants were Caucasian, ages 53 to 67, and the samples were collected at eight centers in six nations throughout Europe from population registries or audiological consultations. The team of investigators analyzed the samples and identified genetic risks.

In the lab, the research team used Affymetrix GeneChip® Human Mapping 500K to score markers across the entire genome of more than 2,000 samples.

Friedman said the next step is developing a laboratory model to test pharmaceuticals for possible treatment of presbycusis in the future.


Story Source:

The above story is based on materials provided by The Translational Genomics Research Institute. Note: Materials may be edited for content and length.


Journal Reference:

  1. Rick A. Friedman et al. Grm7 variants confer susceptibility to age-related hearing impairment. Human Molecular Genetics, Dec 1, 2008 DOI: 10.1093/hmg/ddn402

Cite This Page:

The Translational Genomics Research Institute. "Gene Associated With Age-related Hearing Loss Identified." ScienceDaily. ScienceDaily, 3 December 2008. <www.sciencedaily.com/releases/2008/12/081202080817.htm>.
The Translational Genomics Research Institute. (2008, December 3). Gene Associated With Age-related Hearing Loss Identified. ScienceDaily. Retrieved May 26, 2015 from www.sciencedaily.com/releases/2008/12/081202080817.htm
The Translational Genomics Research Institute. "Gene Associated With Age-related Hearing Loss Identified." ScienceDaily. www.sciencedaily.com/releases/2008/12/081202080817.htm (accessed May 26, 2015).

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