Featured Research

from universities, journals, and other organizations

Virus Discovery Could Lead To Vaccine For West Nile Virus And Dengue Fever

Date:
December 16, 2008
Source:
The University of Queensland
Summary:
New research could contribute to the development of a vaccine and cure for West Nile virus and Dengue fever.

Research conducted at The University of Queensland could contribute to the development of a vaccine and cure for West Nile virus and Dengue fever.

Led by Associate Professor Alexander Khromykh, a team of researchers from UQ's School of Molecular and Microbial Sciences identified a novel characteristic of the virus family to which these diseases belong.

The team found all flaviviruses produced a small molecule which, among other functions, controlled the host's response to viral infection.

This molecule, called a subgenomic noncoding ribonucleic acid (sfRNA), is a part of the virus genome.

"To develop new and effective antiviral strategies, we have to know as much as possible about the virus, or virus family, that we are fighting," Dr Khromykh said.

"As sfRNA is produced by all flaviviruses we tested so far, targeting it with an antiviral therapy may be effective for the whole range of flaviviruses.

"By using reverse genetic engineering we were able to generate viruses that do not produce this sfRNA and showed that these engineered viruses are no longer able to kill their hosts or elicit disease symptoms.

"These engineered viruses offer great potential as vaccine candidates as they are expected to elicit an antiviral immune response similar to the normal virus infection without causing a disease."

Dr Khromykh said by studying mice infected with these engineered West Nile viruses, the team learned more about how the body attempted to combat a flavivirus infection.

The part of the virus the infected cells in the body are unsuccessful in destroying forms the sfRNA, which helps the virus to kill cells and cause potentially deadly diseases, he said.

"We identified sfRNA as a potential antiviral target for the large group of medically important viruses," Dr Khromykh said.

"Moreover, the knowledge obtained from our studies with West Nile virus should be readily applicable for designing anti-viral drugs and engineering similar vaccine candidates for other medically important flaviviruses."

Funded by the National Health and Medical Research Council, this study will be published in the December issue of the journal from Cell Press, Cell Host & Microbe. (Ref: CELLHOST-D-08-00064R3, Khromykh)


Story Source:

The above story is based on materials provided by The University of Queensland. Note: Materials may be edited for content and length.


Cite This Page:

The University of Queensland. "Virus Discovery Could Lead To Vaccine For West Nile Virus And Dengue Fever." ScienceDaily. ScienceDaily, 16 December 2008. <www.sciencedaily.com/releases/2008/12/081211112225.htm>.
The University of Queensland. (2008, December 16). Virus Discovery Could Lead To Vaccine For West Nile Virus And Dengue Fever. ScienceDaily. Retrieved April 17, 2014 from www.sciencedaily.com/releases/2008/12/081211112225.htm
The University of Queensland. "Virus Discovery Could Lead To Vaccine For West Nile Virus And Dengue Fever." ScienceDaily. www.sciencedaily.com/releases/2008/12/081211112225.htm (accessed April 17, 2014).

Share This



More Health & Medicine News

Thursday, April 17, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Could Even Casual Marijuana Use Alter Your Brain?

Could Even Casual Marijuana Use Alter Your Brain?

Newsy (Apr. 16, 2014) A new study conducted by researchers at Northwestern and Harvard suggests even casual marijuana use can alter your brain. Video provided by Newsy
Powered by NewsLook.com
Thousands Of Vials Of SARS Virus Go Missing

Thousands Of Vials Of SARS Virus Go Missing

Newsy (Apr. 16, 2014) A research institute in Paris somehow misplaced more than 2,000 vials of the deadly SARS virus. Video provided by Newsy
Powered by NewsLook.com
Formerly Conjoined Twins Released From Dallas Hospital

Formerly Conjoined Twins Released From Dallas Hospital

Newsy (Apr. 16, 2014) Conjoined twins Emmett and Owen Ezell were separated by doctors in August. Now, nearly nine months later, they're being released from the hospital. Video provided by Newsy
Powered by NewsLook.com
Ebola Outbreak Now Linked To 121 Deaths

Ebola Outbreak Now Linked To 121 Deaths

Newsy (Apr. 15, 2014) The ebola virus outbreak in West Africa is now linked to 121 deaths. Health officials fear the virus will continue to spread in urban areas. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins