Featured Research

from universities, journals, and other organizations

Higher Levels Of Obesity-related Hormone Found In Patients With Psoriasis

Date:
December 19, 2008
Source:
JAMA and Archives Journals
Summary:
Patients with the skin disease psoriasis appear more likely to have higher levels of leptin (a hormone produced by fat cells that may contribute to obesity and other metabolic abnormalities) than persons without psoriasis, according to a new report.

Patients with the skin disease psoriasis appear more likely to have higher levels of leptin (a hormone produced by fat cells that may contribute to obesity and other metabolic abnormalities) than persons without psoriasis, according to a new report.

Related Articles


Psoriasis is an autoimmune disease that results in a red, scaly rash. "Associations among psoriasis, obesity, hypertension, cardiovascular diseases, diabetes mellitus and metabolic syndrome have been reported," the authors write as background information in the article. "Although the underlying mechanisms may be complex, the 'obesity of psoriasis' is thought to be a key link to cardiovascular diseases, including diabetes mellitus, stroke, heart disease, hypertension and myocardial infarction [heart attack]."

Yi-Ju Chen, M.D., of the Taichung Veterans General Hospital and National Chung Hsing University, Taiwan, and colleagues studied 77 patients with psoriasis and 81 individuals who were the same age and sex but did not have psoriasis. In 2006 and 2007, the researchers collected clinical characteristics of the participants, including age, sex, height, weight, any other diseases they had and the severity of their psoriasis. Blood samples were analyzed for levels of leptin, a hormone that helps control food intake, body weight and fat stores and also is related to immune and inflammatory processes.

Individuals with psoriasis were more likely than controls to be obese and to have hypertension (high blood pressure) and elevated blood glucose levels or diabetes. High blood levels of leptin were found more often in females, the obese and those with high blood pressure, metabolic syndrome (a grouping of cardiovascular risk factors that includes hypertension and high cholesterol) or psoriasis.

"After adjustment for sex, body mass index and conventional cardiovascular risk factors (including hypertension and metabolic syndrome), psoriasis was independently associated in our study with hyperleptinemia [high leptin levels]," the authors write. "In addition, hyperleptinemia in psoriasis is associated with higher risk of developing metabolic syndrome. This novel finding links the chronic inflammation status of psoriasis with metabolic disturbances."

The high circulating leptin levels in individuals with psoriasis may derive not only from fat tissue but also from inflammation, they continue. "Body weight loss has been reported to significantly decrease leptin levels and improve insulin sensitivity and may reduce the likelihood of developing metabolic syndrome and adverse cardiovascular diseases," the authors conclude. "Body weight loss could potentially become part of the general treatment of psoriasis, especially in patients with obesity."

This study was supported in part by research grants from Taichung Veterans General Hospital.


Story Source:

The above story is based on materials provided by JAMA and Archives Journals. Note: Materials may be edited for content and length.


Journal Reference:

  1. Chen et al. Psoriasis Independently Associated With Hyperleptinemia Contributing to Metabolic Syndrome. Archives of Dermatology, 2008; 144 (12): 1571 DOI: 10.1001/archderm.144.12.1571

Cite This Page:

JAMA and Archives Journals. "Higher Levels Of Obesity-related Hormone Found In Patients With Psoriasis." ScienceDaily. ScienceDaily, 19 December 2008. <www.sciencedaily.com/releases/2008/12/081215184202.htm>.
JAMA and Archives Journals. (2008, December 19). Higher Levels Of Obesity-related Hormone Found In Patients With Psoriasis. ScienceDaily. Retrieved November 28, 2014 from www.sciencedaily.com/releases/2008/12/081215184202.htm
JAMA and Archives Journals. "Higher Levels Of Obesity-related Hormone Found In Patients With Psoriasis." ScienceDaily. www.sciencedaily.com/releases/2008/12/081215184202.htm (accessed November 28, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Friday, November 28, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Rural India's Low-Cost Sanitary Pad Revolution

Rural India's Low-Cost Sanitary Pad Revolution

AFP (Nov. 28, 2014) — One man hopes his invention -– a machine that produces cheap sanitary pads –- will help empower Indian women. Duration: 01:51 Video provided by AFP
Powered by NewsLook.com
Research on Bats Could Help Develop Drugs Against Ebola

Research on Bats Could Help Develop Drugs Against Ebola

AFP (Nov. 28, 2014) — In Africa's only biosafety level 4 laboratory, scientists have been carrying out experiments on bats to understand how virus like Ebola are being transmitted, and how some of them resist to it. Duration: 01:18 Video provided by AFP
Powered by NewsLook.com
Ebola Leaves Orphans Alone in Sierra Leone

Ebola Leaves Orphans Alone in Sierra Leone

AFP (Nov. 27, 2014) — The Ebola epidemic sweeping Sierra Leone is having a profound effect on the country's children, many of whom have been left without any family members to support them. Duration: 01:02 Video provided by AFP
Powered by NewsLook.com
Experimental Ebola Vaccine Shows Promise In Human Trial

Experimental Ebola Vaccine Shows Promise In Human Trial

Newsy (Nov. 27, 2014) — A recent test of a prototype Ebola vaccine generated an immune response to the disease in subjects. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins