Featured Research

from universities, journals, and other organizations

Gene Technology To Fight Lethal Hospital Acquired Infection

Date:
January 19, 2009
Source:
University of Nottingham
Summary:
Scientists are unraveling the genetic code of one of the most lethal strains of hospital acquired infections.

Scientists at The University of Nottingham are leading a major European study to unravel the genetic code of one of the most lethal strains of hospital acquired infections.

Related Articles


The 3 million euro, three-year study will use gene knock-out technology developed in Nottingham to study the function of genes in a ‘super’ strain of the bacteria Clostridium difficile to discover why it causes more severe disease, kills more people, is harder to eradicate and more resistant to antibiotics.

It is hoped that the HYPERDIFF study, which involves partners from the UK, Slovenia, Italy, France, The Netherlands and Germany and is funded with a grant from the European Community, will lead to better tests to diagnose ‘super’ strains of C.difficile, more effective treatments and, possibly, even a vaccine to protect against the disease.

Since the turn of the new millennium there has been a dramatic increase in the incidence of C.difficile. Currently the most frequently occurring healthcare associated infection, last year it killed more than seven times as many people in the UK as MRSA. Reasons for this increase may include improvements in reporting procedures, the increasing age of the population as the elderly are especially vulnerable, lower standards of hygiene and overcrowding on hospital wards.

However, a further significant factor has been the arrival in Europe of so-called ‘hypervirulent’ strains such as ribotype 027, which are responsible for more severe disease and are more difficult to treat.

Currently, scientists know that the bacteria cause disease by sticking to epithelial cells of the gut lining and releasing two toxins that damage cells leading to the tell-tale symptom of severe diarrhoea. However, there is very little known about the ways in which the bacteria operate and why the strain should be more severe than its less virulent cousins.

Leading the study, Professor Nigel Minton in The University of Nottingham’s School of Molecular Medical Sciences, said: “These hypervirulent organisms seem to be taking over as the dominant strain in outbreaks and, worryingly, there are only two antibiotics which are still effective against them. There is a very real danger that total resistance may arise, and if that happens then this will become an extremely serious problem.

“The idea behind the study is that we investigate the genomes of the hypervirulent strains and identify their differences to the so-called standard strains. In this way, we should get a clearer picture of the whole range of factors involved in its spread and the way in which it causes disease.”

During the three-year study, scientists at Nottingham will use a technology called ClosTron to produce mutant versions of the hypervirulent strains. They will knock out genes one by one and then compare the mutant version to the standard organism to assess the function of each cell.

The project will also investigate whether pets and other domesticated animals are carriers of the bacteria and what effect this may have had on the rise of C.difficile as a community acquired infection.


Story Source:

The above story is based on materials provided by University of Nottingham. Note: Materials may be edited for content and length.


Cite This Page:

University of Nottingham. "Gene Technology To Fight Lethal Hospital Acquired Infection." ScienceDaily. ScienceDaily, 19 January 2009. <www.sciencedaily.com/releases/2009/01/090119142313.htm>.
University of Nottingham. (2009, January 19). Gene Technology To Fight Lethal Hospital Acquired Infection. ScienceDaily. Retrieved December 22, 2014 from www.sciencedaily.com/releases/2009/01/090119142313.htm
University of Nottingham. "Gene Technology To Fight Lethal Hospital Acquired Infection." ScienceDaily. www.sciencedaily.com/releases/2009/01/090119142313.htm (accessed December 22, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Monday, December 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Touch-Free Smart Phone Empowers Mobility-Impaired

Touch-Free Smart Phone Empowers Mobility-Impaired

Reuters - Innovations Video Online (Dec. 21, 2014) A touch-free phone developed in Israel enables the mobility-impaired to operate smart phones with just a movement of the head. Suzannah Butcher reports. Video provided by Reuters
Powered by NewsLook.com
Earthworms Provide Cancer-Fighting Bacteria

Earthworms Provide Cancer-Fighting Bacteria

Reuters - Innovations Video Online (Dec. 21, 2014) Polish scientists isolate bacteria from earthworm intestines which they say may be used in antibiotics and cancer treatments. Suzannah Butcher reports. Video provided by Reuters
Powered by NewsLook.com
Existing Chemical Compounds Could Revive Failing Antibiotics, Says Danish Scientist

Existing Chemical Compounds Could Revive Failing Antibiotics, Says Danish Scientist

Reuters - Innovations Video Online (Dec. 21, 2014) A team of scientists led by Danish chemist Jorn Christensen says they have isolated two chemical compounds within an existing antipsychotic medication that could be used to help a range of failing antibiotics work against killer bacterial infections, such as Tuberculosis. Jim Drury went to meet him. Video provided by Reuters
Powered by NewsLook.com
Hugging It Out Could Help You Ward Off A Cold

Hugging It Out Could Help You Ward Off A Cold

Newsy (Dec. 21, 2014) Carnegie Mellon researchers found frequent hugs can help people avoid stress-related illnesses. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins