Featured Research

from universities, journals, and other organizations

Leukemia Stem Cells Have More In Common With Embryonic Stem Cells Than Adult Stem Cells

Date:
February 12, 2009
Source:
Cell Press
Summary:
Research using a mouse model of human leukemia has provided critical insight into the genetic factors related to the generation and maintenance of myeloid leukemia stem cells. The study is likely to have a profound impact on the future design of therapeutic approaches targeted against cancer stem cells.

Research using a mouse model of human leukemia has provided critical insight into the genetic factors related to the generation and maintenance of myeloid leukemia stem cells. The study, published by Cell Press in the February 6th issue of the journal Cell Stem Cell, is likely to have a profound impact on the future design of therapeutic approaches targeted against cancer stem cells.

Leukemia stem cells (LSCs) were initially described as rare cells that share characteristics with normal hematopoietic stem cells (HSCs). HSCs are a type of partially committed adult stem cells that can give rise to multiple types of blood cells. However, recent research has demonstrated that LSCs can represent a significant fraction of leukemic cells and exhibit characteristics associated with more mature, differentiated myeloid cells rather than the more versatile HSCs.

"Since LSCs may be more numerous and mature than originally proposed, the nature and generality of the hierarchical organization of malignancies has recently been questioned," says senior study author Dr. Michael L. Cleary, from the Department of Pathology at Stanford University. Dr. Cleary and colleagues used a mouse model of human AML to investigate the genes that maintain LSC frequencies and leukemia cell hierarchies.

The researchers found that LSCs are maintained in a self-renewing state by subversion of a transcriptional program that shares features with pluripotent embryonic stem cells (ESCs). This transcriptional program is transiently expressed in normal myeloid precursor cells rather than HSCs or fully mature white blood cells. The authors go on to reveal a link between activation of genes associated with ESCs at an inappropriate stage of white blood cell development, the number of LSCs, and a poor prognosis in leukemia.

"Importantly, the shared transcriptional features of LSCs, ESCs, normal mid-myeloid lineage cells, and a diverse set of poor-prognosis human malignancies support the broader conclusion that cancer stem cells may be aberrantly self-renewing downstream progenitor cells," explains lead study author Dr. Tim Somervaille.

The study also highlights the potential of therapeutic strategies aimed at genes and pathways that are of greater importance to the function of LSCs than HSCs. "These findings may have a substantial clinical impact, as normal HSCs are necessary for regeneration of hematopoiesis following chemotherapy," offers Dr. Cleary.

The researchers include Tim C.P. Somervaille, Stanford University, Stanford, CA, Cancer Research UK Leukaemia Biology Group, Paterson Institute for Cancer Research, University of Manchester, Manchester, UK; Christina J. Matheny, Stanford University, Stanford, CA; Gary J. Spencer, Cancer Research UK Leukaemia Biology Group, Paterson Institute for Cancer Research, University of Manchester, Manchester, UK; Masayuki Iwasaki, Stanford University, Stanford, CA; John L. Rinn, Stanford University, Stanford, CA; Daniela M. Witten, Stanford University, Stanford, CA; Howard Y. Chang, Stanford University, Stanford, CA; Sheila A. Shurtleff, St. Jude Children's Research Hospital, Memphis, TN; James R. Downing, St. Jude Children's Research Hospital, Memphis, TN; and Michael L. Cleary, Stanford University, Stanford, CA.


Story Source:

The above story is based on materials provided by Cell Press. Note: Materials may be edited for content and length.


Cite This Page:

Cell Press. "Leukemia Stem Cells Have More In Common With Embryonic Stem Cells Than Adult Stem Cells." ScienceDaily. ScienceDaily, 12 February 2009. <www.sciencedaily.com/releases/2009/02/090205133742.htm>.
Cell Press. (2009, February 12). Leukemia Stem Cells Have More In Common With Embryonic Stem Cells Than Adult Stem Cells. ScienceDaily. Retrieved September 1, 2014 from www.sciencedaily.com/releases/2009/02/090205133742.htm
Cell Press. "Leukemia Stem Cells Have More In Common With Embryonic Stem Cells Than Adult Stem Cells." ScienceDaily. www.sciencedaily.com/releases/2009/02/090205133742.htm (accessed September 1, 2014).

Share This




More Health & Medicine News

Monday, September 1, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Get on Your Bike! London Cycling Popularity Soars Despite Danger

Get on Your Bike! London Cycling Popularity Soars Despite Danger

AFP (Sep. 1, 2014) Wedged between buses, lorries and cars, cycling in London isn't for the faint hearted. Nevertheless the number of people choosing to bike in the British capital has doubled over the past 15 years. Duration: 02:27 Video provided by AFP
Powered by NewsLook.com
We've Got Mites Living In Our Faces And So Do You

We've Got Mites Living In Our Faces And So Do You

Newsy (Aug. 30, 2014) A new study suggests 100 percent of adult humans (those over 18 years of age) have Demodex mites living in their faces. Video provided by Newsy
Powered by NewsLook.com
Liberia Continues Fight Against Ebola

Liberia Continues Fight Against Ebola

AFP (Aug. 30, 2014) Authorities in Liberia try to stem the spread of the Ebola epidemic by raising awareness and setting up sanitation units for people to wash their hands. Duration: 00:41 Video provided by AFP
Powered by NewsLook.com
California Passes 'yes-Means-Yes' Campus Sexual Assault Bill

California Passes 'yes-Means-Yes' Campus Sexual Assault Bill

Reuters - US Online Video (Aug. 30, 2014) California lawmakers pass a bill requiring universities to adopt "affirmative consent" language in their definitions of consensual sex, part of a nationwide drive to curb sexual assault on campuses. Linda So reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins