Featured Research

from universities, journals, and other organizations

Mutant Rats Resist Warfarin

Date:
February 17, 2009
Source:
BMC Genetics
Summary:
A new series of mutations have been discovered that allow rats to resist the effects of the popular poison warfarin. New research describes 18 new genetic changes found in rats from four continents.

Brown Rat. A new series of mutations have been discovered that allow rats to resist the effects of the popular poison warfarin.
Credit: iStockphoto/Andrew Howe

A new series of mutations have been discovered that allow rats to resist the effects of the popular poison warfarin. New research describes eighteen new genetic changes found in rats from four continents.

Simone Rost from the University of Wuerzburg, Germany, and an international team of researchers studied more than 250 rats and mice from anticoagulant-exposed areas in Europe, East Asia, South Africa and the Americas. Rost explained that, "Resistance against warfarin-like compounds has been reported in rodent populations from many countries around the world and poses a considerable problem for efficacy of pest control."

Warfarin and related compounds are derivatives of the plant toxin coumarin. They prevent blood coagulation by repressing the enzyme vitamin-K reductase (VKOR). Rost and colleagues studied VKORC1, the gene responsible for a key component of the VKOR multiprotein complex. According to the authors, "Mutations in VKORC1 may cause a heritable resistance to warfarin, possibly by preventing coumarin derivatives from interfering with the activity of the reductase enzyme".


Story Source:

The above story is based on materials provided by BMC Genetics. Note: Materials may be edited for content and length.


Journal Reference:

  1. Simone Rost, Hans-Joachim Pelz, Sandra Menzel, Alan D MacNicoll, Vanina Leon, Ki-Joon Song, Thomas Jaekel, Johannes Oldenburg and Clemens R Muller. Novel mutations in the VKORC1 gene of wild rats and mice - a response to 50 years of selection pressure by warfarin? BMC Genetics, (in press)

Cite This Page:

BMC Genetics. "Mutant Rats Resist Warfarin." ScienceDaily. ScienceDaily, 17 February 2009. <www.sciencedaily.com/releases/2009/02/090205214433.htm>.
BMC Genetics. (2009, February 17). Mutant Rats Resist Warfarin. ScienceDaily. Retrieved October 20, 2014 from www.sciencedaily.com/releases/2009/02/090205214433.htm
BMC Genetics. "Mutant Rats Resist Warfarin." ScienceDaily. www.sciencedaily.com/releases/2009/02/090205214433.htm (accessed October 20, 2014).

Share This



More Earth & Climate News

Monday, October 20, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Raw: Powerful Hurricane Gonzalo Heads to Bermuda

Raw: Powerful Hurricane Gonzalo Heads to Bermuda

AP (Oct. 17, 2014) Hurricane Gonzalo pounded Bermuda with wind and heavy surf on Friday, bearing down on the tiny British territory as a powerful Category 3 storm that could raise coastal seas as much as 10 feet. (Oct. 17) Video provided by AP
Powered by NewsLook.com
So, Kangaroos Didn't Always Hop

So, Kangaroos Didn't Always Hop

Newsy (Oct. 16, 2014) Researchers believe an extinct kangaroo species weighed 500 pounds or more and couldn't hop. Video provided by Newsy
Powered by NewsLook.com
Hurricane Gonzalo Is A Category 4 And Heading To Bermuda

Hurricane Gonzalo Is A Category 4 And Heading To Bermuda

Newsy (Oct. 16, 2014) Powerful hurricane could hit Bermuda this weekend, and even if it misses it will likely do some damage. Video provided by Newsy
Powered by NewsLook.com
The Largest Volcano In Centuries Is Spewing Toxic Gas

The Largest Volcano In Centuries Is Spewing Toxic Gas

Newsy (Oct. 16, 2014) One of the largest volcanic eruptions in centuries is occurring on Iceland. The volcano Bardarbunga is producing high levels of sulfur dioxide. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Plants & Animals

Earth & Climate

Fossils & Ruins

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins