Featured Research

from universities, journals, and other organizations

Inhibiting Proteins May Prevent Cartilage Breakdown In Arthritis Patients

Date:
February 19, 2009
Source:
University of Missouri-Columbia
Summary:
Researchers hope to find new therapeutic targets for arthritis by studying the interaction between two proteins that, if interrupted, may prevent arthritis pain caused by joint damage. They have found potential evidence that blocking the proteins responsible for inducing inflammation prevents cartilage breakdown.

Current arthritis medications can ease the pain, but stopping the progression of the disease requires more aggressive treatments: use of very limited available drugs or surgical intervention. University of Missouri researchers hope to find new therapeutic targets for arthritis by studying the interaction between two proteins that, if interrupted, may prevent arthritis pain caused by joint damage.

In a new study, researchers have found potential evidence that blocking the proteins responsible for inducing inflammation prevents cartilage breakdown.

“We are looking to intervene in specific molecular events to prevent the depletion of cartilage in arthritis,” said Bimal K. Ray, professor of veterinary pathobiology in the MU College of Veterinary Medicine. “Certain proteins play a major role in the development of arthritis. When we understand how these proteins interact, we will have a better idea of how to slow or even reverse the progression of the disease.”

When the human body develops arthritis, specific protein functions are altered and inflammation is triggered, leading to pain. In the MU study, Ray examined the interaction between the proteins AP-1 and SAF-1 and found that the interaction of these proteins plays a significant role in inducing inflammation. SAF-1 and AP-1 can partner to work together to induce activation of the MMP-1 gene causing breakdown of collagen (the proteins that constitute cartilage). Arthritis patients start to experience pain when cartilage starts to erode.

Because AP-1 and SAF-1 play a significant role in the activation of the MMP-1 gene, researchers explored the site of the interaction as a possible contact point for competitive inhibition. In competitive inhibition, a molecule binds with an enzyme or a protein to decrease its activity and disable its function. Many pharmaceutical drugs that are successful for treating other diseases rely on enzyme inhibitors. In this study, researchers identified an active site in the SAF-1 protein molecule that is involved in the interaction with AP-1 to induce the expression of the MMP-1 gene.

“In this study, we looked at how and why MMP-1 is activated, particularly in the disease condition,” Ray said. “Once we understand how this gene is activated, we can design drugs to control pathways to reduce the severity of MMP-1-mediated cartilage destruction. We found strong evidence that by blocking SAF-1, MMP-1 expression is inhibited. Now, we will continue to explore the interacting domain of SAF-1 as a possible contact point for competitive inhibition.”


Story Source:

The above story is based on materials provided by University of Missouri-Columbia. Note: Materials may be edited for content and length.


Journal Reference:

  1. Kumar et al. Transcriptional synergy mediated by SAF-1 and AP-1: Critical Role of N-Terminal Polyalanine and Two Zinc Finger Domains of SAF-1. Journal of Biological Chemistry, 2008; 284 (3): 1853 DOI: 10.1074/jbc.M806289200

Cite This Page:

University of Missouri-Columbia. "Inhibiting Proteins May Prevent Cartilage Breakdown In Arthritis Patients." ScienceDaily. ScienceDaily, 19 February 2009. <www.sciencedaily.com/releases/2009/02/090218181907.htm>.
University of Missouri-Columbia. (2009, February 19). Inhibiting Proteins May Prevent Cartilage Breakdown In Arthritis Patients. ScienceDaily. Retrieved October 21, 2014 from www.sciencedaily.com/releases/2009/02/090218181907.htm
University of Missouri-Columbia. "Inhibiting Proteins May Prevent Cartilage Breakdown In Arthritis Patients." ScienceDaily. www.sciencedaily.com/releases/2009/02/090218181907.htm (accessed October 21, 2014).

Share This



More Health & Medicine News

Tuesday, October 21, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

How Nigeria Beat Its Ebola Outbreak

How Nigeria Beat Its Ebola Outbreak

Newsy (Oct. 20, 2014) The World Health Organization has declared Nigeria free of Ebola. Health experts credit a bit of luck and the government's initial response. Video provided by Newsy
Powered by NewsLook.com
Another Study Suggests Viagra Is Good For The Heart

Another Study Suggests Viagra Is Good For The Heart

Newsy (Oct. 20, 2014) An ingredient in erectile-dysfunction medications such as Viagra could improve heart function. Perhaps not surprising, given Viagra's history. Video provided by Newsy
Powered by NewsLook.com
Ebola Worries End for Dozens on U.S. Watch Lists

Ebola Worries End for Dozens on U.S. Watch Lists

Reuters - US Online Video (Oct. 20, 2014) Forty-three people who had contact with Thomas Eric Duncan, the first person diagnosed with Ebola in the U.S., were cleared overnight of twice-daily monitoring after 21 days of showing no symptoms. Rough Cut (no reporter narration). Video provided by Reuters
Powered by NewsLook.com
CDC Calls for New Ebola Safety Guidelines

CDC Calls for New Ebola Safety Guidelines

AP (Oct. 20, 2014) Centers for Disease Control and Prevention Director Dr. Tom Frieden laid out new guidelines for health care workers when dealing with the deadly Ebola virus including new precautions when taking off personal protective equipment. (Oct. 20) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins