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Muscular Dystrophy: Stem Cell Breakthrough Gives New Hope To Sufferers Of Muscle-wasting Diseases

Date:
March 6, 2009
Source:
University of New South Wales
Summary:
An experimental procedure that dramatically strengthens stem cells' ability to regenerate damaged tissue could offer new hope to sufferers of muscle-wasting diseases such as myopathy and muscular dystrophy, according to researchers. The world-first procedure has been successfully used to regrow muscles in a mouse model, but it could be applied to all tissue-based illnesses in humans such as in the liver, pancreas or brain.

An experimental procedure that dramatically strengthens stem cells' ability to regenerate damaged tissue could offer new hope to sufferers of muscle-wasting diseases such as myopathy and muscular dystrophy, according to researchers from the University of New South Wales (UNSW).

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The world-first procedure has been successfully used to regrow muscles in a mouse model, but it could be applied to all tissue-based illnesses in humans such as in the liver, pancreas or brain, the researchers say.

The research team, which is based at UNSW and formerly from Sydney's Westmead Children's Hospital, adapted a technique currently being trialled in bone marrow transplantation. Adult stem cells are given a gene that makes them resistant to chemotherapy, which is used to clean out damaged cells and allow the new stem cells to take hold.

A paper detailing the breakthrough appears in the journal Stem Cells the week of March 3.

The ability of adult stem cells to regenerate whole tissues opens up a world of new possibilities for many human diseases, according to the lead authors of the paper, Professor Peter Gunning, Professor Edna Hardeman and Dr Antonio Lee, from UNSW's School of Medical Sciences.

"The beauty of this technique is that chemotherapy makes space for stem cells coming into muscle and also gives the stem cells an advantage over the locals. It's the first strategy that gives the good guys the edge in the battle to cure sick tissues," Professor Gunning said.

"What has been the realm of science fiction is looking more and more like the medicine of the future," he said.

The procedure solves one of the major hurdles involving stem cell therapy – getting the cells to survive for more than an hour or so after inserting them into damaged tissue.

"In muscle, most stem cells die in the first hour or are present in such low numbers that they are not much help," Professor Gunning said. "Until now, the new healthy cells had no advantage over the existing damaged tissue and were getting out-competed.

While trials of the procedure are at the pre-clinical stage, researchers are looking to launch human trials treating specific forms of muscular dystrophy such as oculopharyngeal dystrophy within the next three to five years.

The research was made possible by the support of the Oncology Children's Foundation who recognised the potential to take the technology beyond an initial focus on childhood brain tumours.


Story Source:

The above story is based on materials provided by University of New South Wales. Note: Materials may be edited for content and length.


Cite This Page:

University of New South Wales. "Muscular Dystrophy: Stem Cell Breakthrough Gives New Hope To Sufferers Of Muscle-wasting Diseases." ScienceDaily. ScienceDaily, 6 March 2009. <www.sciencedaily.com/releases/2009/03/090305102711.htm>.
University of New South Wales. (2009, March 6). Muscular Dystrophy: Stem Cell Breakthrough Gives New Hope To Sufferers Of Muscle-wasting Diseases. ScienceDaily. Retrieved January 29, 2015 from www.sciencedaily.com/releases/2009/03/090305102711.htm
University of New South Wales. "Muscular Dystrophy: Stem Cell Breakthrough Gives New Hope To Sufferers Of Muscle-wasting Diseases." ScienceDaily. www.sciencedaily.com/releases/2009/03/090305102711.htm (accessed January 29, 2015).

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