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Why Anesthesia Is Associated With Cognitive Impairment And Risk Of Alzheimer's Disease

Date:
March 12, 2009
Source:
IOS Press BV
Summary:
Scientists report that anesthesia induces phosphorylation of tau. Tau is a key neuronal protein involved in neurodegeneration in Alzheimer's disease (AD) and several other neurodegenerative disorders. Anesthesia has previously been found to be associated with cognitive impairment and the risk for AD. This study helps elucidate the molecular mechanisms underlying these associations.

Scientists from The New York State Office of Mental Retardation and Developmental Disabilities’ (OMRDD) New York State Institute for Basic Research in Developmental Disabilities (IBR) report in the Journal of Alzheimer’s Disease that anesthesia induces phosphorylation of tau. Tau is a key neuronal protein involved in neurodegeneration in Alzheimer’s disease (AD) and several other neurodegenerative disorders.

Anesthesia has previously been found to be associated with cognitive impairment and the risk for AD. This study helps elucidate the molecular mechanisms underlying these associations.

The researchers found that in test animals, anesthesia for short periods (30 seconds to 5 minutes) induced tau phosphorylation at some selective phosphorylation sites to a small but significant extent. Anesthesia for a longer time (1 hour) induced much more dramatic phosphorylation at the same sites, possibly as a result of anesthesia-induced hypothermia. The observation that anesthesia did not induce global hyperphosphorylation of brain proteins, but instead specific hyperphosphorylation of tau protein at the AD-related abnormal hyperphosphorylation sites suggests that tau hyperphosphorylation might be the mechanism that links anesthesia and the risk of cognitive impairment and/or AD.

AD is the most common cause of dementia in adults and affects approximately 27 million individuals worldwide and over four million in the United States alone. Most AD cases are sporadic and are believed to be caused by multiple factors. Understanding the mechanism by which anesthesia may increase the risk for cognitive impairment will help in the design of strategies for preventing and treating dementia and AD. “This is a very important finding related to Alzheimer’s disease,” said OMRDD Commissioner Diana Jones Ritter. “I am pleased that these findings will lead to helping people live richer lives through the research findings.”

The study was carried out by the Brain Metabolism Laboratory at IBR. Headed by Dr. Cheng-Xin Gong, the laboratory is focusing its research on the roles of several signaling and metabolic factors in neurodegeneration and deregulated neurodevelopment, especially related to AD and autism.


Story Source:

The above story is based on materials provided by IOS Press BV. Note: Materials may be edited for content and length.


Journal Reference:

  1. Run X, Liang Z, Zhang L, Iqbal K, Grundke-Iqbal I, Gong C-X. Anesthesia induces phosphorylation of tau. Journal of Alzheimer's Disease, March 2009

Cite This Page:

IOS Press BV. "Why Anesthesia Is Associated With Cognitive Impairment And Risk Of Alzheimer's Disease." ScienceDaily. ScienceDaily, 12 March 2009. <www.sciencedaily.com/releases/2009/03/090310084840.htm>.
IOS Press BV. (2009, March 12). Why Anesthesia Is Associated With Cognitive Impairment And Risk Of Alzheimer's Disease. ScienceDaily. Retrieved August 21, 2014 from www.sciencedaily.com/releases/2009/03/090310084840.htm
IOS Press BV. "Why Anesthesia Is Associated With Cognitive Impairment And Risk Of Alzheimer's Disease." ScienceDaily. www.sciencedaily.com/releases/2009/03/090310084840.htm (accessed August 21, 2014).

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