Featured Research

from universities, journals, and other organizations

TB Vaccine Developed, Clinical Trial Starting

Date:
March 19, 2009
Source:
McMaster University
Summary:
Researchers are about to launch Canada's first tuberculosis vaccine clinical trial. Today, TB ranks second only to HIV among infectious killers worldwide, claiming nearly two million lives annually.

McMaster University researchers are about to launch Canada's first tuberculosis (TB) vaccine clinical trial with a vaccine totally designed, manufactured and tested within McMaster.

Development of the vaccine for the landmark trial was led by Zhou Xing, a professor in the Department of Pathology and Molecular Medicine. The vaccine was manufactured in the Robert E. Fitzhenry Vector Laboratory of the Institute of Molecular Medicine and Health on campus, Canada's first university laboratory certified to provide vectors (delivery agents) for use in clinical trials in humans. Most of the pre-clinical testing of the vaccine was undertaken at McMaster.

The phase 1 clinical trial, which has the approval of Health Canada, will begin to recruit 48 healthy volunteers between 18 and 55 years of age in mid-April. Over 12 – 18 months researchers will evaluate the safety of the new vaccine (currently called AdAg85A vaccine) and assess blood samples from vaccinated healthy human volunteers to determine if the vaccine is generating a desired immune response. The trial will be conducted by a team of infectious disease physicians, vaccine manufacturing specialists and immunologists at McMaster.

The announcement of the new TB vaccine trial coincides with World TB Day on Tuesday, March 24, when health authorities and researchers around the world will be raising awareness about the need for new TB vaccines.

Today, TB ranks second only to HIV among infectious killers worldwide, claiming nearly two million lives annually. The disease is evolving faster than therapies with the emergence in recent years of strains that are resistant to every last one of the antibiotic defences.

The McMaster researchers developed the new TB vaccine using a genetically modified adenovirus – a virus responsible for the common cold. After removing a small portion of the gene, they inserted part of the TB gene responsible for immunity. "It is natural ways of making the body use its own immune machinery," said Dr. Fiona Smaill, a professor of medicine and chair of the Department of Pathology and Molecular Medicine at McMaster.

"Based on all pre-clinical studies carried out on animals, including mice, guinea pigs (who are very prone to TB) and cattle, this vaccine appears to be a very promising candidate vaccine," Xing said.

The vaccine, manufactured to clinical grade standards at McMaster, has passed all the testing required for its use in humans, Smaill said. Along with regulatory approval from Ottawa, the TB vaccine trial has been approved by the research ethics board at McMaster University and Hamilton Health Sciences (HSC).

Smaill said initial financial support for the trial has come from the Centre for Gene Therapeutics, led by Jack Gauldie, and the Michael G. DeGroote Institute for Infectious Disease Research, both at McMaster University.

The launch of the TB vaccine trial is part of McMaster's focus on research into infectious diseases that now claim millions of lives worldwide, specifically TB and HIV, with a focus on malaria planned for the near future.


Story Source:

The above story is based on materials provided by McMaster University. Note: Materials may be edited for content and length.


Cite This Page:

McMaster University. "TB Vaccine Developed, Clinical Trial Starting." ScienceDaily. ScienceDaily, 19 March 2009. <www.sciencedaily.com/releases/2009/03/090319152051.htm>.
McMaster University. (2009, March 19). TB Vaccine Developed, Clinical Trial Starting. ScienceDaily. Retrieved July 29, 2014 from www.sciencedaily.com/releases/2009/03/090319152051.htm
McMaster University. "TB Vaccine Developed, Clinical Trial Starting." ScienceDaily. www.sciencedaily.com/releases/2009/03/090319152051.htm (accessed July 29, 2014).

Share This




More Health & Medicine News

Tuesday, July 29, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Deadly Ebola Virus Threatens West Africa

Deadly Ebola Virus Threatens West Africa

AP (July 28, 2014) West African nations and international health organizations are working to contain the largest Ebola outbreak in history. It's one of the deadliest diseases known to man, but the CDC says it's unlikely to spread in the U.S. (July 28) Video provided by AP
Powered by NewsLook.com
$15B Deal on Vets' Health Care Reached

$15B Deal on Vets' Health Care Reached

AP (July 28, 2014) A bipartisan deal to improve veterans health care would authorize at least $15 billion in emergency spending to fix a veterans program scandalized by long patient wait times and falsified records. (July 28) Video provided by AP
Powered by NewsLook.com
Two Americans Contract Ebola in Liberia

Two Americans Contract Ebola in Liberia

Reuters - US Online Video (July 28, 2014) Two American aid workers in Liberia test positive for Ebola while working to combat the deadliest outbreak of the virus ever. Linda So reports. Video provided by Reuters
Powered by NewsLook.com
Traditional African Dishes Teach Healthy Eating

Traditional African Dishes Teach Healthy Eating

AP (July 28, 2014) Classes are being offered nationwide to encourage African Americans to learn about cooking fresh foods based on traditional African cuisine. The program is trying to combat obesity, heart disease and other ailments often linked to diet. (July 28) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins