Featured Research

from universities, journals, and other organizations

New Link In Liver Cancer

Date:
April 7, 2009
Source:
Rockefeller University Press
Summary:
Liver damage can be triggered by various insults, including hepatitis infection or alcohol-induced cirrhosis. In severe cases, this damage can lead to cancer. A new study reveals how one protein helps decide the fate of damaged livers in mice.

In the absence of STAT5, expression of STAT3 (red) surges.
Credit: DOI: 10.1084/jem.20080003

Liver damage can be triggered by various insults, including hepatitis infection or alcohol-induced cirrhosis. In severe cases, this damage can lead to cancer. A new study by researchers at the National Institutes of Health and Osaka University reveals how one protein helps decide the fate of damaged livers in mice.

Liver cells rely on signals triggered by growth hormone to survive and multiply—functions that go haywire in cancer. Normally, growth hormone works by activating a signaling network inside liver cells that includes a protein called STAT5. When the researchers removed STAT5 from liver cells, cancer ensued.

The normally protective effect of STAT5 was traced to its ability to hitch itself to a damage-inducing protein called TGFbeta and trigger its destruction. Without STAT5, TGFbeta levels soared, and growth hormone activated a related protein, STAT3, which is known to promote tumor growth.

TGFbeta and STAT5 appear to be adversaries in the liver, according to the study. STAT5 protects the liver by breaking down TGFbeta. But when TGFbeta is abundant—as occurs in people with chronic liver damage—growth hormone activates the cancer-promoting STAT3 instead of the protective STAT5. These results might help explain how chronic liver damage can eventually lead to cancer.

The study will be published online on March 30th in the Journal of Experimental Medicine.


Story Source:

The above story is based on materials provided by Rockefeller University Press. Note: Materials may be edited for content and length.


Cite This Page:

Rockefeller University Press. "New Link In Liver Cancer." ScienceDaily. ScienceDaily, 7 April 2009. <www.sciencedaily.com/releases/2009/03/090330091551.htm>.
Rockefeller University Press. (2009, April 7). New Link In Liver Cancer. ScienceDaily. Retrieved August 28, 2014 from www.sciencedaily.com/releases/2009/03/090330091551.htm
Rockefeller University Press. "New Link In Liver Cancer." ScienceDaily. www.sciencedaily.com/releases/2009/03/090330091551.htm (accessed August 28, 2014).

Share This




More Health & Medicine News

Thursday, August 28, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Killer Amoeba Found in Louisiana Water System

Killer Amoeba Found in Louisiana Water System

AP (Aug. 28, 2014) State health officials say testing has confirmed the presence of a killer amoeba in a water system serving three St. John the Baptist Parish towns. (Aug. 28) Video provided by AP
Powered by NewsLook.com
Who Could Be Burnt by WHO's E-Cigs Move?

Who Could Be Burnt by WHO's E-Cigs Move?

Reuters - Business Video Online (Aug. 28, 2014) The World Health Organisation has called for the regulation of electronic cigarettes as both tobacco and medical products. Ciara Lee looks at the impact of the move on the tobacco industry. Video provided by Reuters
Powered by NewsLook.com
CDC Director On Ebola Outbreak: 'It's Worse Than I Feared'

CDC Director On Ebola Outbreak: 'It's Worse Than I Feared'

Newsy (Aug. 28, 2014) CDC director Tom Frieden says the Ebola outbreak is even worse than he feared. But he also said there's still hope to contain it. Video provided by Newsy
Powered by NewsLook.com
How A 'Rule Of Thumb' Could Slow Down Drinking

How A 'Rule Of Thumb' Could Slow Down Drinking

Newsy (Aug. 28, 2014) A study suggests people who follow a "rule of thumb" when pouring wine dispense less than those who don't have a particular amount in mind. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins