Featured Research

from universities, journals, and other organizations

After Heart Attack, Bone Marrow Stem Cells Increase Blood Flow Within Heart

Date:
April 6, 2009
Source:
Emory University
Summary:
Patients treated with their own bone marrow stem cells after a heart attack experienced increased circulation within the heart, a study has found.

Patients treated with their own bone marrow stem cells after a heart attack experienced increased circulation within the heart, a study by Emory University School of Medicine physicians has found.

Principal investigator Arshed Quyyumi, MD, professor of medicine at Emory University School of Medicine, presents the results Monday at the American College of Cardiology conference in Orlando.

"These results show that treatment with a patient's own bone marrow stem cells has the potential to reduce long-term complications after a heart attack," Quyyumi says. "We are encouraged by these results and are planning to conduct a more extensive study."

A severe enough heart attack can lead to remodeling of the heart muscle and increased risk of heart failure and other complications.

Several groups of researchers around the world have reported clinical trials in which cells from the bone marrow are used to try to restore the heart's pumping power, with mixed results. This study was one of the first to use a preparation of bone marrow cells enriched for endothelial progenitor cells, which are thought to replenish the linings of blood vessels. Emory University, Vanderbilt University, The Lindner Research Center, Cincinnati, and Texas Heart Center in Houston participated.

In the clinical trial, which began in June 2006, 31 patients were treated by angioplasty and stent placement after a heart attack. Within a week after their heart attacks, 16 of the patients had bone marrow cells infused into the coronary artery where a blockage caused the heart attack.

Members of this group received three different amounts of magnetically sorted bone marrow cells (5, 10 and 15 million cells). The control group received standard medication only. No significant adverse events were reported. The patients will be followed for up to five years.

Doctors assessed healing and remodeling of patients' hearts with nuclear (single photon emission computed tomography) stress testing, magnetic resonance imaging, and echocardiography three months and six months later. Patients receiving higher doses of cells had greater improvement in blood flow within the heart than those patients treated with lower doses or those receiving medication alone.

"This is critical information for future study design – the more cells a patient receives, the more beneficial effect we see in the heart," Quyyumi says.

Higher doses of cells also appeared to provide some benefit in cardiac function, determined by measuring the percentage of blood pumped out with each heartbeat and tissue death due to loss of adequate blood supply, but these results were not considered significant statistically.

Edmund Waller, MD, PhD, Emory professor of hematology and medical oncology, was co-principal investigator of the study. Emory researchers Stam Lerakis, PhD, Fabio Esteves, MD, and John Oshinski, PhD, conducted blind interpretation of the tests in Emory core laboratories.

The study was funded by biotech company Amorcyte, whose technology was used to sort the bone marrow cells. Quyyumi and Waller are paid consultants for Amorcyte.

ACC 2009 Late-Breaking Abstract Title: CD34+ Cell Infusion after ST Segment Elevation Myocardial Infarction is Associated with Improved Perfusion


Story Source:

The above story is based on materials provided by Emory University. Note: Materials may be edited for content and length.


Cite This Page:

Emory University. "After Heart Attack, Bone Marrow Stem Cells Increase Blood Flow Within Heart." ScienceDaily. ScienceDaily, 6 April 2009. <www.sciencedaily.com/releases/2009/03/090330102517.htm>.
Emory University. (2009, April 6). After Heart Attack, Bone Marrow Stem Cells Increase Blood Flow Within Heart. ScienceDaily. Retrieved July 25, 2014 from www.sciencedaily.com/releases/2009/03/090330102517.htm
Emory University. "After Heart Attack, Bone Marrow Stem Cells Increase Blood Flow Within Heart." ScienceDaily. www.sciencedaily.com/releases/2009/03/090330102517.htm (accessed July 25, 2014).

Share This




More Health & Medicine News

Friday, July 25, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

New Painkiller Designed To Discourage Abuse: Will It Work?

New Painkiller Designed To Discourage Abuse: Will It Work?

Newsy (July 24, 2014) The FDA approved Targiniq ER on Wednesday, a painkiller designed to keep users from abusing it. Like any new medication, however, it has doubters. Video provided by Newsy
Powered by NewsLook.com
Doctor At Forefront Of Fighting Ebola Outbreak Gets Ebola

Doctor At Forefront Of Fighting Ebola Outbreak Gets Ebola

Newsy (July 24, 2014) Sheik Umar Khan has treated many of the people infected in the Ebola outbreak, and now he's become one of them. Video provided by Newsy
Powered by NewsLook.com
Condemned Man's US Execution Takes Nearly Two Hours

Condemned Man's US Execution Takes Nearly Two Hours

AFP (July 24, 2014) America's death penalty debate raged Thursday after it took nearly two hours for Arizona to execute a prisoner who lost a Supreme Court battle challenging the experimental lethal drug cocktail. Duration: 00:55 Video provided by AFP
Powered by NewsLook.com
Can Watching TV Make You Feel Like A Failure?

Can Watching TV Make You Feel Like A Failure?

Newsy (July 24, 2014) A study by German researchers claims watching TV while you're stressed out can make you feel guilty and like a failure. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

    Health News

      Environment News

        Technology News



          Save/Print:
          Share:

          Free Subscriptions


          Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

          Get Social & Mobile


          Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

          Have Feedback?


          Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
          Mobile: iPhone Android Web
          Follow: Facebook Twitter Google+
          Subscribe: RSS Feeds Email Newsletters
          Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins