Featured Research

from universities, journals, and other organizations

Intestinal Parasites Alter Immunity In Cholera Patients

Date:
April 7, 2009
Source:
Public Library of Science
Summary:
Cholera patients also infected with parasitic intestinal worms have a significantly reduced immune response to the cholera toxin, according to a new report. Results of the study suggest that parasitic infection could reduce immunity to future cholera infection and may compromise the effectiveness of cholera vaccines.

Cholera patients also infected with parasitic intestinal worms have a significantly reduced immune response to the cholera toxin, according to a new report.

Related Articles


Results of the study from a collaborative team led by researchers at Massachusetts General Hospital (MGH) and the International Centre for Diarrhoeal Disease Research, Bangladesh (ICDDR,B) suggest that parasitic infection could reduce immunity to future cholera infection and may compromise the effectiveness of cholera vaccines.

Vibrio cholerae infections cause an estimated 5 million cases of cholera annually worldwide, primarily in impoverished areas with poor sanitation. Intestinal parasites, such as the worms called helminths, are also common in developing areas when cholera is endemic, but there has been little investigation into the impact of infection with both types of pathogen.

For the current study, the research team enrolled about 400 cholera patients who came to ICDDR,B between 2001 and 2006. After verifying that participants were infected with V. cholerae, the investigators examined stool samples for the presence of intestinal parasites. Blood samples were collected the day after patients enrolled in the study and 7 and 21 days later.

Of 361 patients with confirmed cholera who completed the 21-day follow up, 53 were also infected with at least one intestinal parasite, most frequently helminths. Analysis of participants' blood samples showed that helminth-infected patients had a significantly reduced immune response to the cholera toxin, with the greatest reduction in the IgA antibodies that are secreted in the intestine. The response against a sugar-based molecule that is also important in the immune response was not reduced, implying that the reduced response could relate to the effects of helminth infection on CD4+ helper T cells.

"It's been a puzzle as to why cholera vaccines that initially look so promising in trials in volunteers in Europe and the United States have been much less effective in inducing a strong immune system response in countries where cholera occurs. Our study supports the idea that co-infection with intestinal worms may be part of the explanation for that discrepancy," says Jason Harris, of the MGH Division of Infectious Disease, the study's lead author. "Although we need additional studies to understand the reason for the association between helminths and decreased immune responses to cholera, this study shows that deworming programs could have an added benefit, especially in countries where cholera is present."


Story Source:

The above story is based on materials provided by Public Library of Science. Note: Materials may be edited for content and length.


Journal Reference:

  1. Harris JB, Podolsky MJ, Bhuiyan TR, Chowdhury F, Khan AI, et al. Immunologic Responses to Vibrio cholerae in Patients Co-Infected with Intestinal Parasites in Bangladesh. PLoS Neglected Tropical Diseases, 2009; 3 (3): e403 DOI: 10.1371/journal.pntd.0000403

Cite This Page:

Public Library of Science. "Intestinal Parasites Alter Immunity In Cholera Patients." ScienceDaily. ScienceDaily, 7 April 2009. <www.sciencedaily.com/releases/2009/03/090330200605.htm>.
Public Library of Science. (2009, April 7). Intestinal Parasites Alter Immunity In Cholera Patients. ScienceDaily. Retrieved November 23, 2014 from www.sciencedaily.com/releases/2009/03/090330200605.htm
Public Library of Science. "Intestinal Parasites Alter Immunity In Cholera Patients." ScienceDaily. www.sciencedaily.com/releases/2009/03/090330200605.htm (accessed November 23, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Sunday, November 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Ebola-Hit Sierra Leone's Late Cocoa Leaves Bitter Taste

Ebola-Hit Sierra Leone's Late Cocoa Leaves Bitter Taste

AFP (Nov. 23, 2014) The arable district of Kenema in Sierra Leone -- at the centre of the Ebola outbreak in May -- has been under quarantine for three months as the cocoa harvest comes in. Duration: 01:32 Video provided by AFP
Powered by NewsLook.com
WFP: Ebola Risks Heightened Among Women Throughout Africa

WFP: Ebola Risks Heightened Among Women Throughout Africa

AFP (Nov. 21, 2014) Having children has always been a frightening prospect in Sierra Leone, the world's most dangerous place to give birth, but Ebola has presented an alarming new threat for expectant mothers. Duration: 00:37 Video provided by AFP
Powered by NewsLook.com
Could Your Genes Be The Reason You're Single?

Could Your Genes Be The Reason You're Single?

Newsy (Nov. 21, 2014) Researchers in Beijing discovered a gene called 5-HTA1, and carriers are reportedly 20 percent more likely to be single. Video provided by Newsy
Powered by NewsLook.com
Raw: Paralyzed Marine Walks With Robotic Braces

Raw: Paralyzed Marine Walks With Robotic Braces

AP (Nov. 21, 2014) Marine Corps officials say a special operations officer left paralyzed by a sniper's bullet in Afghanistan walked using robotic leg braces in a ceremony to award him a Bronze Star. (Nov. 21) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins