For the study, published in the April issue of The Journal of Nuclear Medicine, researchers selected a group of patients with known or suspected—albeit stable—IHD. Those with previous coronary artery bypass surgery, chronic kidney failure and hyperthyroidism were excluded, leaving 492 study subjects between the ages of 55 and 75. Each of these underwent a complete diagnostic work-up that included a medical history, physical examination, blood tests, electrocardiography at rest, two-dimensional echocardiography and myocardial perfusion imaging (gated SPECT) after stress and at rest.

Patients also underwent coronary arteriography, which is currently the standard clinical procedure for diagnosing IHD, according to the American Heart Association. This invasive test is performed by inserting a catheter into the femoral artery of the leg and threading it into the aorta. A contrast dye is then injected, and X-rays record areas where narrowing or blockage in one or more coronary arteries has occurred.

During the next 37 months, patients returned for periodic examinations in an outpatient setting. Armed with the resulting data, the researchers determined that of the techniques investigated—including coronary arteriography—gated SPECT is the best predictor of future cardiac events.

"The prognostic value of stress testing with myocardial perfusion imaging has been investigated for several years," said Alessia Gimelli, MD, at the Clinical Physiology Institute CNR, G. Monasterio Foundation in Pisa, Italy. "However, substantial changes in nuclear cardiology have occurred over the past two decades that have led to improved techniques. The clinical profile of patients with IHD has also changed, with patients often being older and affected by more diseases than in the past. We were therefore surprised to see that gated SPECT remains the best predictor of future cardiac events in patients with IHD."

Furthermore, although left ventricular ejection fraction (the heart's action of pumping blood into the body) is more commonly used in clinical practice to predict patient outcome, this study revealed that the extent of damage to the heart muscle—as shown in the SPECT images—is a better prognosticator of how patients will fare. This ability to identify individuals at risk for future cardiac events, such as heart attacks, has considerable appeal because the early initiation of preventive therapies may alter the course of the disease, noted the researchers.

"Risk stratification allows us to categorize patients according to the severity of their disease and risk of future cardiac events," said Dr. Gimelli. "As a result, we are able to allocate resources where needed and treat the sickest patients more aggressively."

Gated SPECT is a noninvasive nuclear medicine procedure involving an injection of a small amount of radioactive material that circulates in the bloodstream to show if the heart muscle is receiving adequate blood supply under stress and/or rest conditions, explained the researchers. SPECT imaging performed after stress reveals the distribution of the radiopharmaceutical and therefore the relative myocardial perfusion (blood flow in the heart) to the different regions of the heart muscle. The resulting set of SPECT images provides quantitative information regarding myocardial perfusion after stress and at rest, as well as the heart as it contracts.

Myocardial perfusion imaging stress testing is sensitive to even the most modest changes in blood flow and can determine whether the heart is receiving enough blood and oxygen. In this way, gated SPECT provides information regarding the presence of myocardial infarction (heart attack) and myocardial ischemia, explained Dr. Gimelli.

Since its introduction in the late 1980s, gated SPECT has become one of the most commonly performed cardiology procedures in nuclear medicine departments. Automation of the image processing and quantification has made this technique highly reproducible, practical and user friendly in clinical settings. It is similar to a standard SPECT study, except that many more images are acquired. Diagnosis is made by comparing stress images to an additional set of images obtained at rest.

IHD is characterized by a temporary reduction in blood supply to the heart muscle and is usually the result of coronary artery disease (atherosclerosis). According to the American Heart Association, it is the leading cause of death in the United States and the European Union.

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