Featured Research

from universities, journals, and other organizations

Targeting Specific Disease-causing Bacteria In The Mouth

Date:
April 9, 2009
Source:
Society for General Microbiology
Summary:
Researchers have developed a narrow-spectrum antibiotic that can target a particular species of bacteria without harming the other "good" bacteria present.

Research to develop a narrow-spectrum antibiotic that can target a particular species of bacteria without harming the other "good" bacteria present was described at the Society for General Microbiology meeting at Harrogate April 2.

Professor Kim Brogden from the University of Iowa attached a broad-spectrum antibiotic to a protein that targets a receptor on a particular bacterium's surface. When this newly-formed narrow-spectrum antibiotic was tested on a mix of bacteria that included the target organism, Porphyromonas gingivalis, a cause of gum disease, low concentrations of the antibiotic killed the P. gingivalis bacteria but left the other two bacterial species in the mix untouched.

Antibiotics have clear clinical benefits in treating oral infections like gum (periodontal) disease. This therapy reduces the number of harmful bacteria in patients who have received non-surgical and surgical treatments. Hard and soft tissue damage is much less in patients who have received antibiotics than in patients who have not received these drugs. Unfortunately, complications are associated with antibiotic use.

Side effects such as nausea, vomiting, abdominal discomfort, diarrhoea, allergic skin rashes and fever can be caused by penicillin and related drugs. Overuse of antibiotics leads to the development of drug-resistant bacteria. And antibiotics can kill the normal bacterial population of the mouth, urogenital tract, and gastrointestinal tract. This can lead to infections by opportunistic Candida albicans yeast in the mouth and urogenital tract or the bacterium Clostridium difficile in the gastrointestinal tract.

A targeted approach is needed to kill specific disease-causing bacteria in complex environments, said Professor Brogden. "We are developing an antibiotic that can target and kill a particular pathogen without harming or altering the composition of the normal, more beneficial bacteria in the body. Such a product would provide a variety of new treatments for oral diseases as well as a means of prevention."


Story Source:

The above story is based on materials provided by Society for General Microbiology. Note: Materials may be edited for content and length.


Cite This Page:

Society for General Microbiology. "Targeting Specific Disease-causing Bacteria In The Mouth." ScienceDaily. ScienceDaily, 9 April 2009. <www.sciencedaily.com/releases/2009/04/090401200431.htm>.
Society for General Microbiology. (2009, April 9). Targeting Specific Disease-causing Bacteria In The Mouth. ScienceDaily. Retrieved July 25, 2014 from www.sciencedaily.com/releases/2009/04/090401200431.htm
Society for General Microbiology. "Targeting Specific Disease-causing Bacteria In The Mouth." ScienceDaily. www.sciencedaily.com/releases/2009/04/090401200431.htm (accessed July 25, 2014).

Share This




More Health & Medicine News

Friday, July 25, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Beatings and Addiction: Pakistan Drug 'clinic' Tortures Patients

Beatings and Addiction: Pakistan Drug 'clinic' Tortures Patients

AFP (July 24, 2014) A so-called drugs rehab 'clinic' is closed down in Pakistan after police find scores of ‘patients’ chained up alleging serial abuse. Duration 03:05 Video provided by AFP
Powered by NewsLook.com
Too Few Teens Receiving HPV Vaccination, CDC Says

Too Few Teens Receiving HPV Vaccination, CDC Says

Newsy (July 24, 2014) The Centers for Disease Control and Prevention is blaming doctors for the low number of children being vaccinated for HPV. Video provided by Newsy
Powered by NewsLook.com
New Painkiller Designed To Discourage Abuse: Will It Work?

New Painkiller Designed To Discourage Abuse: Will It Work?

Newsy (July 24, 2014) The FDA approved Targiniq ER on Wednesday, a painkiller designed to keep users from abusing it. Like any new medication, however, it has doubters. Video provided by Newsy
Powered by NewsLook.com
Doctor At Forefront Of Fighting Ebola Outbreak Gets Ebola

Doctor At Forefront Of Fighting Ebola Outbreak Gets Ebola

Newsy (July 24, 2014) Sheik Umar Khan has treated many of the people infected in the Ebola outbreak, and now he's become one of them. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

    Health News

      Environment News

        Technology News



          Save/Print:
          Share:

          Free Subscriptions


          Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

          Get Social & Mobile


          Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

          Have Feedback?


          Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
          Mobile: iPhone Android Web
          Follow: Facebook Twitter Google+
          Subscribe: RSS Feeds Email Newsletters
          Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins