Featured Research

from universities, journals, and other organizations

World-first High Blood Pressure Treatment Trialled In Australia

Date:
April 12, 2009
Source:
Monash University
Summary:
A world-first breakthrough to treat high blood pressure has been successfully trialled in Melbourne, Australia. The clinical trial showed significant improvement in blood pressure of participants who were given a new catheter-based treatment where blood pressure lowering medication had failed.

A world-first breakthrough to treat high blood pressure has been successfully trialled in Melbourne, Australia.

The clinical trial showed significant improvement in blood pressure of participants who were given a new catheter-based treatment where blood pressure lowering medication had failed.

Director of Monash University's Centre of Cardiovascular Research and Education in Therapeutics, Professor Henry Krum led the research collaboration between Monash, the Baker Heart and Diabetes Institute, and St Vincent's Hospital to develop the new surgical technique that disrupts nerves around the kidneys to dramatically reduce high blood pressure.

The technique could benefit those at high risk of heart attack or stroke from high blood pressure that resists conventional drug treatments.

Professor Krum presented these data in a late breaking clinical trial session at The American College of Cardiology's 58th Annual Scientific Session earlier this week and was lead author on a simultaneous publication in The Lancet.

The results are set to revolutionise high blood pressure treatment in patients around the world.

Professor Henry Krum said the treatment would benefit those five to twenty per cent of patients with high blood pressure who do not respond to medication.

"Patients who underwent the procedure had a significant reduction in their blood pressure levels and we were able therefore to reduce their risk of severe stroke or heart attack," Professor Krum said.

A total of 50 patients were recruited from Australia and overseas for the trial conducted by a team of researchers, which included Professor Henry Krum, from Monash University, Professor Markus Schlaich and Professor Murray Esler from Baker IDI and Professor Rob Whitbourn from St Vincent's Hospital, Melbourne.

Professor Krum said the trial results were the most significant in the treatment of high blood pressure since the introduction of the drugs that are in use today.

"We showed an excellent safety profile of this brief, catheter-based therapy. No long-term adverse events resulted from the procedure. Therapeutic renal denervation led to a large and persistant decrease in blood pressure, which was achieved in patients resistant to multiple existing hypertensive drug types. Moreover, reduction of blood pressure was evident as early as 1 month, was further reduced at 3 months, and persisted through subsequent assessments," Professor Krum said.

The procedure is carried out under local anaesthetic and uses radio energy frequency, delivered to the targeted nerve area via catheter. As a result the nerves are silenced in the renal artery, which supplies blood to the kidneys.

Researchers had long-believed that this region was a key regulator of blood pressure, but until these trial results the theory had not been successfully trialled.

"The catheter allowed us to target a very specific area to deliver the right amount of frequency to the nerves without damaging the surrounding areas," Professor Krum said.


Story Source:

The above story is based on materials provided by Monash University. Note: Materials may be edited for content and length.


Journal Reference:

  1. Henry Krum, Markus Schlaich, Rob Whitbourn, Paul A Sobotka, Jerzy Sadowski, Krzysztof Bartus, Boguslaw Kapelak, Anthony Walton, Horst Sievert, Suku Thambar, William T Abraham, Murray Esler. Catheter-based renal sympathetic denervation for resistant hypertension: a multicentre safety and proof-of-principle cohort study. The Lancet, 2009; DOI: 10.1016/S0140-6736(09)60566-3

Cite This Page:

Monash University. "World-first High Blood Pressure Treatment Trialled In Australia." ScienceDaily. ScienceDaily, 12 April 2009. <www.sciencedaily.com/releases/2009/04/090403104231.htm>.
Monash University. (2009, April 12). World-first High Blood Pressure Treatment Trialled In Australia. ScienceDaily. Retrieved September 2, 2014 from www.sciencedaily.com/releases/2009/04/090403104231.htm
Monash University. "World-first High Blood Pressure Treatment Trialled In Australia." ScienceDaily. www.sciencedaily.com/releases/2009/04/090403104231.htm (accessed September 2, 2014).

Share This




More Health & Medicine News

Tuesday, September 2, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

U.N. Says Ebola Travel Restrictions Will Cause Food Shortage

U.N. Says Ebola Travel Restrictions Will Cause Food Shortage

Newsy (Sep. 2, 2014) The U.N. says the problem is two-fold — quarantine zones and travel restrictions are limiting the movement of both people and food. Video provided by Newsy
Powered by NewsLook.com
Get on Your Bike! London Cycling Popularity Soars Despite Danger

Get on Your Bike! London Cycling Popularity Soars Despite Danger

AFP (Sep. 1, 2014) Wedged between buses, lorries and cars, cycling in London isn't for the faint hearted. Nevertheless the number of people choosing to bike in the British capital has doubled over the past 15 years. Duration: 02:27 Video provided by AFP
Powered by NewsLook.com
Can You Train Your Brain To Eat Healthy?

Can You Train Your Brain To Eat Healthy?

Newsy (Sep. 1, 2014) New research says if you condition yourself to eat healthy foods, eventually you'll crave them instead of junk food. Video provided by Newsy
Powered by NewsLook.com
We've Got Mites Living In Our Faces And So Do You

We've Got Mites Living In Our Faces And So Do You

Newsy (Aug. 30, 2014) A new study suggests 100 percent of adult humans (those over 18 years of age) have Demodex mites living in their faces. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins