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Another Anti-cancer Effect Of The 'Longevity' Protein SIRT1 Identified

Date:
April 15, 2009
Source:
Rockefeller University Press
Summary:
Scientists have identified another anti-cancer effect of the "longevity" protein SIRT1. By speeding the destruction of the tumor promoter c-Myc, SIRT1 curbs cell division.
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Cells that make c-Myc proliferate in culture (left), but not when SIRT1 is present (right).
Credit: Yuan, J., et al. 2009. J. Cell Biol. doi:10.1083/jcb.200809167

Yuan et al. have identified another anti-cancer effect of the "longevity" protein SIRT1. By speeding the destruction of the tumor promoter c-Myc, SIRT1 curbs cell division. 

The yeast and nematode equivalents of SIRT1 are fountains of youth that stretch lifespan. Whether SIRT1 slows aging in mammals isn't certain, but it's beneficial in other ways. The protein tunes up metabolism, reducing blood levels of glucose and insulin, and might forestall neurodegenerative illnesses such as Alzheimer's disease and ALS. Given its pro-life credentials, you might expect SIRT1 to inhibit cancer. And several studies suggest that it does. But other work indicates that the protein aids tumors. For example, SIRT1 chops off acetyl groups, which can inactivate the tumor suppressor p53.

Yuan et al. determined SIRT1's effect on the transcription factor c-Myc, whose expression surges in many breast, colon, and liver cancers. The two proteins are tangled in a regulatory loop, the team found. c-Myc latched onto SIRT1's promoter, spurring cells to manufacture more SIRT1. In turn, SIRT1 detached acetyl groups from c-Myc, hastening its breakdown. To test SIRT1's effects on tumor growth, the researchers implanted cancerous cells expressing c-Myc into nude mice that lack immune defenses. Boosting production of SIRT1 blocked tumor formation.

How deacetylation of c-Myc sparks its destruction is still a mystery. The researchers say that the results don't necessarily conflict with studies suggesting that SIRT1 is pro-tumor. Whether SIRT1 promotes or prevents cancer probably depends on the situation.

The study will be published online April 13 and will appear in the April 20 print issue of the Journal of Cell Biology.

Reference: Yuan, J., et al. 2009. J. Cell Biol. doi:10.1083/jcb.200809167.


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Rockefeller University Press. "Another Anti-cancer Effect Of The 'Longevity' Protein SIRT1 Identified." ScienceDaily. ScienceDaily, 15 April 2009. <www.sciencedaily.com/releases/2009/04/090413083311.htm>.
Rockefeller University Press. (2009, April 15). Another Anti-cancer Effect Of The 'Longevity' Protein SIRT1 Identified. ScienceDaily. Retrieved July 2, 2015 from www.sciencedaily.com/releases/2009/04/090413083311.htm
Rockefeller University Press. "Another Anti-cancer Effect Of The 'Longevity' Protein SIRT1 Identified." ScienceDaily. www.sciencedaily.com/releases/2009/04/090413083311.htm (accessed July 2, 2015).

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