Featured Research

from universities, journals, and other organizations

New Imaging Analysis Predicts Brain Tumor Survival

Date:
April 23, 2009
Source:
University of Michigan Health System
Summary:
As early as one week after beginning treatment for brain tumors, a new imaging analysis method was able to predict which patients would live longer, researchers have found.

Scans showing gliomas that did not (left) and did (right) respond to treatment. Top images are parametric response maps superimposed onto pre-treatment MRIs. Graphs show distribution of relative cerebral blood volume for entire tumor volume.
Credit: Image courtesy of University of Michigan Health System

As early as one week after beginning treatment for brain tumors, a new imaging analysis method was able to predict which patients would live longer, researchers from the University of Michigan Comprehensive Cancer Center have found.

Related Articles


The method uses a standard magnetic resonance imaging, or MRI, protocol to monitor changes over time in tumor blood volume within individual voxels of the image, rather than a composite view of average change within the tumor. This parametric response map allowed researchers to see specific areas in which tumor blood volume increased or decreased, that may have canceled each other out when looking at the changes as an average.

"What we have potentially is a generalized analytical approach that we can use to quantify treatment intervention in patients," says study author Brian Ross, Ph.D., professor of radiology and biological chemistry at the U-M Medical School and co-director of the Molecular Imaging Program at the U-M Comprehensive Cancer Center.

The researchers looked at 44 people with high-grade glioma, a type of brain tumor, who were treated with chemotherapy and radiation. Each participant underwent MRIs before treatment, and one week and three weeks after starting treatment. The researchers then looked at the relative cerebral blood volume and the relative cerebral blood flow of the tumor to analyze voxel-wise changes among the serial scans.

Looking at standard comparisons using averages, the scans indicated no change one week and three weeks into treatment. But, using the parametric response map approach, the researchers were able to show changes in the tumor's blood volume and blood flow after one week that corresponded to the patient's overall survival.

"We're seeing treatment response earlier into the treatment, and responses that couldn't be detected at all looking at average changes. We could detect this after just one week, which is amazing for brain tumors," says study author Craig Galbαn, Ph.D., assistant professor of radiology at the U-M Medical School.

High grade gliomas have a high mortality rate, with people surviving only an average of 12 months after diagnosis. Typically, patients receive six to seven weeks of treatment, followed by a traditional MRI scan six weeks after completing therapy to determine if the tumor shrank. If the cancer did not respond to the treatment, a new approach may be tried.

The researchers believe this approach might also be useful with other imaging techniques such as PET and CT scans.

Brain cancer statistics: 21,810 Americans will be diagnosed with brain cancer this year and 13,070 will die from the disease, according to the American Cancer Society.

Additional authors include Thomas Chenevert, Ph.D.; Charles Meyer, Ph.D.; Christina Tsien, M.D., Theodore Lawrence, M.D., Ph.D.; Daniel Hamstra, M.D., Ph.D.; Larry Junck, M.D.; Pia Sundgren, M.D., Ph.D.; Timothy D. Johnson, Ph.D.; David Ross; and Alnawaz Rehemtulla, Ph.D.

Funding was provided by the National Institutes of Health.

The University of Michigan has filed a patent application on this technology.

Journal reference: Nature Medicine, doi: 10.1038/nm.1919


Story Source:

The above story is based on materials provided by University of Michigan Health System. Note: Materials may be edited for content and length.


Cite This Page:

University of Michigan Health System. "New Imaging Analysis Predicts Brain Tumor Survival." ScienceDaily. ScienceDaily, 23 April 2009. <www.sciencedaily.com/releases/2009/04/090419133903.htm>.
University of Michigan Health System. (2009, April 23). New Imaging Analysis Predicts Brain Tumor Survival. ScienceDaily. Retrieved March 29, 2015 from www.sciencedaily.com/releases/2009/04/090419133903.htm
University of Michigan Health System. "New Imaging Analysis Predicts Brain Tumor Survival." ScienceDaily. www.sciencedaily.com/releases/2009/04/090419133903.htm (accessed March 29, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Sunday, March 29, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

S. Leone in New Anti-Ebola Lockdown

S. Leone in New Anti-Ebola Lockdown

AFP (Mar. 28, 2015) — Sierra Leone imposed a three-day nationwide lockdown Friday for the second time in six months in a bid to prevent a resurgence of the deadly Ebola virus. Duration: 01:17 Video provided by AFP
Powered by NewsLook.com
These Popular Antibiotics Can Cause Permanent Nerve Damage

These Popular Antibiotics Can Cause Permanent Nerve Damage

Newsy (Mar. 27, 2015) — A popular class of antibiotic can leave patients in severe pain and even result in permanent nerve damage. Video provided by Newsy
Powered by NewsLook.com
WH Plan to Fight Antibiotic-Resistant Germs

WH Plan to Fight Antibiotic-Resistant Germs

AP (Mar. 27, 2015) — The White House on Friday announced a five-year plan to fight the threat posed by antibiotic-resistant bacteria amid fears that once-treatable germs could become deadly. (March 27) Video provided by AP
Powered by NewsLook.com
House Ready to Pass Medicare Doc Bill

House Ready to Pass Medicare Doc Bill

AP (Mar. 26, 2015) — In rare bipartisan harmony, congressional leaders pushed a $214 billion bill permanently blocking physician Medicare cuts toward House passage Thursday, moving lawmakers closer to resolving a problem that has plagued them for years. (March 26) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins