Featured Research

from universities, journals, and other organizations

Developmental Drug Helps Protect Against Radiation Damage

Date:
April 24, 2009
Source:
University of Pittsburgh Schools of the Health Sciences
Summary:
A drug currently under development protects cells from the damaging effects of radiation exposure, a new study suggests. JP4-039 targets the mitochondria, the energy-producing areas of all cells. For this study, cells treated immediately after irradiation with JP4-039 demonstrated significant radioprotection.

A drug currently under development at the University of Pittsburgh School of Medicine protects cells from the damaging effects of radiation exposure, a new study suggests. Results of the study, Abstract Number 3988, are being presented at the 100th annual meeting of the American Association for Cancer Research (AACR), April 18 to 22 in Denver.

The study, led by Joel Greenberger, M.D., professor and chairman of the Department of Radiation Oncology at Pitt, is overseen by Pitt's Center for Medical Countermeasures Against Radiation. The center is dedicated to identifying and developing small molecule radiation protectors and mitigators that can be easily accessed and administered in the event of a large-scale radiological or nuclear emergency.

JP4-039 assists the mitochondria, the energy generator of all cells, in combating irradiation-induced cell death. For this study, cells treated immediately after irradiation with JP4-039 demonstrated significant radioprotection, suggesting a potential role for the drug as a mitigator of radiation damage.

"Currently, no drugs on the market counteract the effects of radiation exposure," said Dr. Greenberger. "We know this drug can counteract the damage caused by irradiation, and now we want to develop the ideal dosage, one that is effective for the general population while remaining non-toxic. Our goal is to take this drug through a phase I clinical trial and, once the dosage is established, develop the drug for late-stage clinical trials and market licensing."

This study was funded by the Biomedical Advanced Research and Development Authority (BARDA), Department of Health and Human Services. Last year, BARDA awarded Dr. Greenberger and members of his lab $2.7 million to help develop a radiation mitigator drug that could counter the effects of radiation exposure in case of large-scale public exposure. T


Story Source:

The above story is based on materials provided by University of Pittsburgh Schools of the Health Sciences. Note: Materials may be edited for content and length.


Cite This Page:

University of Pittsburgh Schools of the Health Sciences. "Developmental Drug Helps Protect Against Radiation Damage." ScienceDaily. ScienceDaily, 24 April 2009. <www.sciencedaily.com/releases/2009/04/090422151830.htm>.
University of Pittsburgh Schools of the Health Sciences. (2009, April 24). Developmental Drug Helps Protect Against Radiation Damage. ScienceDaily. Retrieved April 18, 2014 from www.sciencedaily.com/releases/2009/04/090422151830.htm
University of Pittsburgh Schools of the Health Sciences. "Developmental Drug Helps Protect Against Radiation Damage." ScienceDaily. www.sciencedaily.com/releases/2009/04/090422151830.htm (accessed April 18, 2014).

Share This



More Health & Medicine News

Friday, April 18, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Scientists Create Stem Cells From Adult Skin Cells

Scientists Create Stem Cells From Adult Skin Cells

Newsy (Apr. 17, 2014) The breakthrough could mean a cure for some serious diseases and even the possibility of human cloning, but it's all still a way off. Video provided by Newsy
Powered by NewsLook.com
Obama: 8 Million Healthcare Signups

Obama: 8 Million Healthcare Signups

AP (Apr. 17, 2014) President Barack Obama gave a briefing Thursday announcing 8 million people have signed up under the Affordable Care Act. He blasted continued Republican efforts to repeal the law. (April 17) Video provided by AP
Powered by NewsLook.com
Is Apathy A Sign Of A Shrinking Brain?

Is Apathy A Sign Of A Shrinking Brain?

Newsy (Apr. 17, 2014) A recent study links apathetic feelings to a smaller brain. Researchers say the results indicate a need for apathy screening for at-risk seniors. Video provided by Newsy
Powered by NewsLook.com
Could Even Casual Marijuana Use Alter Your Brain?

Could Even Casual Marijuana Use Alter Your Brain?

Newsy (Apr. 16, 2014) A new study conducted by researchers at Northwestern and Harvard suggests even casual marijuana use can alter your brain. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins