Featured Research

from universities, journals, and other organizations

Muscle Deterioration In Patients With Lung Disease Seen Connected To Heightened Carbon Dioxide Levels In The Blood

Date:
April 24, 2009
Source:
Hebrew University of Jerusalem
Summary:
Muscle deterioration in patients with lung diseases might be a direct consequence of high carbon dioxide levels in their blood, scientists have found.

Muscle deterioration in patients with lung diseases might be a direct consequence of high carbon dioxide levels in their blood, an international team of researchers headed by Prof. Yosef Gruenbaum of the Hebrew University of Jerusalem has found.

The incidence of lung diseases continues to increase in the world's populations. For example, one in seven persons in the UK is affected by some form of chronic lung disease, most commonly chronic obstructive pulmonary disease (COPD) and asthma.

Many of these diseases also cause, in the worst cases, muscle deterioration as well as elevated levels of carbon dioxide (hypercapnia) in the bloodstream. In a normal situation, the lungs allow for a proper balance of oxygen from the atmosphere reaching the bloodstream and carbon dioxide from the bloodstream being transferred to the atmosphere.

It is still a matter of some controversy whether the high carbon dioxide levels in patients with chronic lung disease actually cause damage to those patients and specifically whether the loss of muscle is a consequence of those heightened levels.

Prof. Gruenbaum and his Ph.D. student Kfir Sharabi from the Department of Genetics at The Hebrew University, in collaboration with the groups of Dr. Amos J. Simon and Dr. Gideon Rechavi from the Sheba Medical Center and Tel Aviv University, and Dr. Jacob I. Sznajder, Dr. Richard I. Morimoto and Dr. Greg J. Beitel from Northwestern University in the U.S., teamed together to answer these questions. The results of their research appeared in a recent study published in the Proceedings of the National Academy of Sciences (PNAS) in the US.

They used the worm C. elegans, in which many basic processes are discovered, to study its response to induced elevated carbon dioxide levels. They found that levels exceeding 9% (normal level in living beings is around 5%) reduced the worm's spontaneous movement capability, which was accompanied by deterioration of body muscle.

(These results suggest re-evaluating the consequences of the procedure of permissive hypercapnia, also known as therapeutic hypercapnia, in which patients with acute lung injury are treated with increased levels of carbon dioxide.)

In addition, there were signs that the experimental animals showed slower development, were less fertile, but, surprisingly, had an increased lifespan. Another unexpected result was the large number of genes that showed specific and dynamic changes after only one hour of exposure to the heightened carbon dioxide levels.

The researchers noted also that physiological and molecular response to hypercapnia appeared to be different from responses to heat shock or to low oxygen levels.


Story Source:

The above story is based on materials provided by Hebrew University of Jerusalem. Note: Materials may be edited for content and length.


Cite This Page:

Hebrew University of Jerusalem. "Muscle Deterioration In Patients With Lung Disease Seen Connected To Heightened Carbon Dioxide Levels In The Blood." ScienceDaily. ScienceDaily, 24 April 2009. <www.sciencedaily.com/releases/2009/04/090423082921.htm>.
Hebrew University of Jerusalem. (2009, April 24). Muscle Deterioration In Patients With Lung Disease Seen Connected To Heightened Carbon Dioxide Levels In The Blood. ScienceDaily. Retrieved October 2, 2014 from www.sciencedaily.com/releases/2009/04/090423082921.htm
Hebrew University of Jerusalem. "Muscle Deterioration In Patients With Lung Disease Seen Connected To Heightened Carbon Dioxide Levels In The Blood." ScienceDaily. www.sciencedaily.com/releases/2009/04/090423082921.htm (accessed October 2, 2014).

Share This



More Health & Medicine News

Thursday, October 2, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Pregnancy Spacing Could Have Big Impact On Autism Risks

Pregnancy Spacing Could Have Big Impact On Autism Risks

Newsy (Oct. 1, 2014) A new study says children born less than one year and more than five years after a sibling can have an increased risk for autism. Video provided by Newsy
Powered by NewsLook.com
Robotic Hair Restoration

Robotic Hair Restoration

Ivanhoe (Oct. 1, 2014) A new robotic procedure is changing the way we transplant hair. The ARTAS robot leaves no linear scarring and provides more natural results. Video provided by Ivanhoe
Powered by NewsLook.com
Insertable Cardiac Monitor

Insertable Cardiac Monitor

Ivanhoe (Oct. 1, 2014) A heart monitor the size of a paperclip that can save your life. The “Reveal Linq” allows a doctor to monitor patients with A-Fib on a continuous basis for up to 3 years! Video provided by Ivanhoe
Powered by NewsLook.com
Attacking Superbugs

Attacking Superbugs

Ivanhoe (Oct. 1, 2014) Two weapons hospitals can use to attack superbugs. Scientists in Ireland created a new gel resistant to superbugs, and a robot that can disinfect a room in minutes. Video provided by Ivanhoe
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins