Science News

... from universities, journals, and other research organizations

Suppressor Of Cytokine Signaling (SOCS)-1 Inhibits Prostate Cancer Growth

May 4, 2009 — Zoran Culig and colleagues at the Innsbruck Medical University, Austria have discovered that SOCS-1 negatively regulates prostate cancer proliferation.


Share This:

This report can be found in the May 2009 issue of The American Journal of Pathology.

SOCS family members are expressed in a variety of cancers, including chronic myeloid leukemia, melanoma, and prostate cancer. The role of the various SOCS family members in carcinogenesis, however, may be tissue dependent.

Neuwirt et al identified SOCS-1 expression in multiple prostate cancer cell lines as well as in tissues from prostate cancer patients. They found that SOCS-1 blocks proliferation of prostate cancer cells and that inhibition of SOCS-1 expression stimulated tumor cell growth.

SOCS-1, therefore, plays a negative regulatory role in prostate cancer proliferation. In future studies they will address "other possible aspects of SOCS-1 action in carcinoma of the prostate, such as regulation of the immune response."

Share this story on Facebook, Twitter, and Google:

Other social bookmarking and sharing tools:

|

Story Source:

The above story is reprinted from materials provided by American Journal of Pathology.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. Neuwirt H, Puhr M, Santer FR, Susani M, Doppler W, Marcias G, Rauch V, Brugger M, Hobisch A, Kenner L, Culig Z. Suppressor of Cytokine Signaling (SOCS)-1 Is Expressed in Human Prostate Cancer and Exerts Growth-Inhibitory Function through Down-Regulation of Cyclins and Cyclin-Dependent Kinases. American Journal Of Pathology, 2009; 174 (5): 1921 DOI: 10.2353/ajpath.2009.080751
APA

MLA

Note: If no author is given, the source is cited instead.

Search ScienceDaily

Number of stories in archives: 137,146

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily's archives for related news topics,
the latest news stories, reference articles, science videos, images, and books.

Recommend ScienceDaily on Facebook, Twitter, and Google:

Other social bookmarking and sharing services:

|

 
  more breaking science news

Social Networks


Recommend ScienceDaily on Facebook, Twitter, and Google +1:

Other social bookmarking and sharing tools:

|

Breaking News

... from NewsDaily.com

In Other News ...

Science Video News


Detecting Prostate Cancer Earlier

A new blood test is more reliable at finding prostate cancer in its early stages by detecting a protein marker in blood plasma. Doctors say the new. ...  > full story

Strange Science News

 

Free Subscriptions

... from ScienceDaily

Get the latest science news with our free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Feedback

... we want to hear from you!

Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?

Post this page to your favorite social bookmarking site:
Include this item in your blog or web site:
Cite this article in your essay, paper, or report:
Email this page's link to a friend or colleague: