Featured Research

from universities, journals, and other organizations

Suppressor Of Cytokine Signaling (SOCS)-1 Inhibits Prostate Cancer Growth

Date:
May 4, 2009
Source:
American Journal of Pathology
Summary:
Researchers in Austria have discovered that SOCS-1 negatively regulates prostate cancer proliferation. SOCS family members are expressed in a variety of cancers, including chronic myeloid leukemia, melanoma, and prostate cancer.

Zoran Culig and colleagues at the Innsbruck Medical University, Austria have discovered that SOCS-1 negatively regulates prostate cancer proliferation.

Related Articles


This report can be found in the May 2009 issue of The American Journal of Pathology.

SOCS family members are expressed in a variety of cancers, including chronic myeloid leukemia, melanoma, and prostate cancer. The role of the various SOCS family members in carcinogenesis, however, may be tissue dependent.

Neuwirt et al identified SOCS-1 expression in multiple prostate cancer cell lines as well as in tissues from prostate cancer patients. They found that SOCS-1 blocks proliferation of prostate cancer cells and that inhibition of SOCS-1 expression stimulated tumor cell growth.

SOCS-1, therefore, plays a negative regulatory role in prostate cancer proliferation. In future studies they will address "other possible aspects of SOCS-1 action in carcinoma of the prostate, such as regulation of the immune response."


Story Source:

The above story is based on materials provided by American Journal of Pathology. Note: Materials may be edited for content and length.


Journal Reference:

  1. Neuwirt H, Puhr M, Santer FR, Susani M, Doppler W, Marcias G, Rauch V, Brugger M, Hobisch A, Kenner L, Culig Z. Suppressor of Cytokine Signaling (SOCS)-1 Is Expressed in Human Prostate Cancer and Exerts Growth-Inhibitory Function through Down-Regulation of Cyclins and Cyclin-Dependent Kinases. American Journal Of Pathology, 2009; 174 (5): 1921 DOI: 10.2353/ajpath.2009.080751

Cite This Page:

American Journal of Pathology. "Suppressor Of Cytokine Signaling (SOCS)-1 Inhibits Prostate Cancer Growth." ScienceDaily. ScienceDaily, 4 May 2009. <www.sciencedaily.com/releases/2009/04/090426082554.htm>.
American Journal of Pathology. (2009, May 4). Suppressor Of Cytokine Signaling (SOCS)-1 Inhibits Prostate Cancer Growth. ScienceDaily. Retrieved October 24, 2014 from www.sciencedaily.com/releases/2009/04/090426082554.htm
American Journal of Pathology. "Suppressor Of Cytokine Signaling (SOCS)-1 Inhibits Prostate Cancer Growth." ScienceDaily. www.sciencedaily.com/releases/2009/04/090426082554.htm (accessed October 24, 2014).

Share This



More Health & Medicine News

Friday, October 24, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

WHO: Millions of Ebola Vaccine Doses by 2015

WHO: Millions of Ebola Vaccine Doses by 2015

AP (Oct. 24, 2014) The World Health Organization said on Friday that millions of doses of two experimental Ebola vaccines could be ready for use in 2015 and five more experimental vaccines would start being tested in March. (Oct. 24) Video provided by AP
Powered by NewsLook.com
Doctor in NYC Quarantined With Ebola

Doctor in NYC Quarantined With Ebola

AP (Oct. 24, 2014) An emergency room doctor who recently returned to the city after treating Ebola patients in West Africa has tested positive for the virus. He's quarantined in a hospital. (Oct. 24) Video provided by AP
Powered by NewsLook.com
Breakfast Debate: To Eat Or Not To Eat?

Breakfast Debate: To Eat Or Not To Eat?

Newsy (Oct. 23, 2014) Conflicting studies published in the same week re-ignited the debate over whether we should be eating breakfast. Video provided by Newsy
Powered by NewsLook.com
Ebola Fears Keep Guinea Hospitals Empty

Ebola Fears Keep Guinea Hospitals Empty

AP (Oct. 23, 2014) Fears of Ebola are keeping doctors and patients alike away from hospitals in the West African nation of Guinea. (Oct. 23) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins