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Ancestor Of HIV In Primates May Be Surprisingly Young

Date:
May 6, 2009
Source:
Public Library of Science
Summary:
The ancestors of the simian immunodeficiency viruses (SIVs) that jumped from chimpanzees and monkeys, and ignited the HIV/AIDS pandemic in humans, have been dated to just a few centuries ago. These ages are substantially younger than previous estimates.

The ancestors of the simian immunodeficiency viruses (SIVs) that jumped from chimpanzees and monkeys, and ignited the HIV/AIDS pandemic in humans, have been dated to just a few centuries ago. These ages are substantially younger than previous estimates, according to a new study from The University of Arizona in Tucson.

SIV has crossed over from chimpanzees and sooty mangabeys to humans at least eleven times, giving rise to several HIV lineages. Although HIV is a virulent pathogen in humans, SIV rarely causes disease in these species or the dozens of other African primate species it naturally infects. That these non-human primates typically remain unaffected after virus exposure has led to the hypothesis that there had been millions of years of coevolution between SIVs and their primate hosts.

The researchers, Joel Wertheim and Dr. Michael Worobey, estimated a rate of virus evolution using viral genetic sequences that had been isolated from infected humans, chimpanzees, and sooty mangabeys between 1975 and 2005. They inferred that the viruses currently circulating in sooty mangabeys and in chimpanzees evolved from ancestors dating to 1809 (1729–1875) and 1492 (1266–1685), respectively. Surprisingly, the independently estimated 'molecular clock' of the monkey viruses was virtually identical to the famously swift rate at which mutations accumulate in HIV genomes.

The authors note that unaccounted-for biases could be masking a deeper age of SIV. They suggest that if these biases do exist, their causes need to be investigated because they might also affect the ability to properly estimate the age of HIV and other viruses.

This work was supported by the Department of Ecology and Evolutionary Biology at the University of Arizona and the David and Lucile Packard Foundation. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.


Story Source:

The above story is based on materials provided by Public Library of Science. Note: Materials may be edited for content and length.


Journal Reference:

  1. Wertheim et al. Dating the Age of the SIV Lineages That Gave Rise to HIV-1 and HIV-2. PLoS Computational Biology, 2009; 5 (5): e1000377 DOI: 10.1371/journal.pcbi.1000377

Cite This Page:

Public Library of Science. "Ancestor Of HIV In Primates May Be Surprisingly Young." ScienceDaily. ScienceDaily, 6 May 2009. <www.sciencedaily.com/releases/2009/05/090501091024.htm>.
Public Library of Science. (2009, May 6). Ancestor Of HIV In Primates May Be Surprisingly Young. ScienceDaily. Retrieved July 28, 2014 from www.sciencedaily.com/releases/2009/05/090501091024.htm
Public Library of Science. "Ancestor Of HIV In Primates May Be Surprisingly Young." ScienceDaily. www.sciencedaily.com/releases/2009/05/090501091024.htm (accessed July 28, 2014).

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