Featured Research

from universities, journals, and other organizations

Cancer: Dealing With Blocked Bile Ducts

Date:
May 15, 2009
Source:
Helmholtz Association of German Research Centres
Summary:
A consequence of the different cancers of the hepatobiliary system is blocked bile ducts. However, artificial catheters known as "stents" can remediate this problem. Stents are medical implants which reopen narrowed bile ducts to allow the outflow of bile. However, bacteria colonize these catheters forming dense communities, so-called biofilms. Inside these biofilms, bacteria are not only protected from the immune response initiated by the host but also from antibiotics.

A consequence of the different cancers of the hepatobiliary system is blocked bile ducts. However, artificial catheters known as "stents" can remediate this problem. Stents are medical implants which reopen narrowed bile ducts to allow the outflow of bile. However, bacteria colonize these catheters forming dense communities, so-called biofilms. Inside these biofilms, bacteria are not only protected from the immune response initiated by the host but also from antibiotics.

Since the bacterial community is unable to be controlled via antibiotics, the catheters become blocked by the biofilms, which then have to be exchanged on a regular basis, an invasive process.

Scientists of the Helmholtz-Centre for Infection Research (HZI) in Braunschweig have analyzed biliary stents from patients being treated at the medical clinics in Salzgitter and Braunschweig. They would like to know which bacteria inhabit these stents so that such knowledge can facilitate the development of medications tailored to combat against development of these biofilms. The HZI-Scientists identified specific bacterial species as main colonizers of these stents. In addition they statistically evaluated the composition of the bacterial communities of the catheters. Their results have now been published by the scientific journal International Society for Microbial Ecology Journal.

The Scientists of the HZI Department "Microbial Pathogenesis" used material from biliary stents of patients where old catheters had been replaced by new ones. For this reason, they collaborated with the Surgery Clinic of the Braunschweig General Hospital and the Department of Internal Medicine of the Klinikum Salzgitter. The Klinikum Salzgitter is the most specialized and experienced clinic for biliary stent replacement in the region, where each week patients receive new biliary stents. "This had the advantage that we could compare a huge set of samples" Dietmar Pieper, Group leader in the Department of Microbial Pathogenesis said. "This huge set of samples could only be analyzed as we did not try to culture the bacteria on plates, but used sophisticated culture-independent methods" Pieper said. The main goals of the scientists were to determine the composition of the bacterial communities in different biliary stents, their interactions with each other and which bacteria most often occur.

"Certainly, there are significant differences between the patients and consequently between the communities" Pieper said. In general, however, the Scientists could identify recurrent dominant colonizers, such as the bacterium Streptococcus anginosus. Interactions and dependencies among the bacteria were gathered by statistical means. "We could show that the colonization of the stents followed principles ressembling those known for biofilm development of dental plaques" Pieper said.

In the future, the scientists will analyze the influence of different environmental factors such as a healthy lifestyle on the composition of such communities. "With these results an important cornerstone was laid towards the development of new methods and medications", Pieper said.


Story Source:

The above story is based on materials provided by Helmholtz Association of German Research Centres. Note: Materials may be edited for content and length.


Journal Reference:

  1. Scheithauer et al. Characterization of the complex bacterial communities colonizing biliary stents reveals a host-dependent diversity. The ISME Journal, 2009; DOI: 10.1038/ismej.2009.36

Cite This Page:

Helmholtz Association of German Research Centres. "Cancer: Dealing With Blocked Bile Ducts." ScienceDaily. ScienceDaily, 15 May 2009. <www.sciencedaily.com/releases/2009/05/090511101658.htm>.
Helmholtz Association of German Research Centres. (2009, May 15). Cancer: Dealing With Blocked Bile Ducts. ScienceDaily. Retrieved August 29, 2014 from www.sciencedaily.com/releases/2009/05/090511101658.htm
Helmholtz Association of German Research Centres. "Cancer: Dealing With Blocked Bile Ducts." ScienceDaily. www.sciencedaily.com/releases/2009/05/090511101658.htm (accessed August 29, 2014).

Share This




More Health & Medicine News

Friday, August 29, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

3 Things To Know About The Ebola Outbreak's Progression

3 Things To Know About The Ebola Outbreak's Progression

Newsy (Aug. 29, 2014) Here are three things you need to know about the deadly Ebola outbreak's progression this week. Video provided by Newsy
Powered by NewsLook.com
Killer Amoeba Found in Louisiana Water System

Killer Amoeba Found in Louisiana Water System

AP (Aug. 28, 2014) State health officials say testing has confirmed the presence of a killer amoeba in a water system serving three St. John the Baptist Parish towns. (Aug. 28) Video provided by AP
Powered by NewsLook.com
Who Could Be Burnt by WHO's E-Cigs Move?

Who Could Be Burnt by WHO's E-Cigs Move?

Reuters - Business Video Online (Aug. 28, 2014) The World Health Organisation has called for the regulation of electronic cigarettes as both tobacco and medical products. Ciara Lee looks at the impact of the move on the tobacco industry. Video provided by Reuters
Powered by NewsLook.com
CDC Director On Ebola Outbreak: 'It's Worse Than I Feared'

CDC Director On Ebola Outbreak: 'It's Worse Than I Feared'

Newsy (Aug. 28, 2014) CDC director Tom Frieden says the Ebola outbreak is even worse than he feared. But he also said there's still hope to contain it. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins