Featured Research

from universities, journals, and other organizations

Drug Deliver With Nanotechnology: Capsules Encapsulated

Date:
May 20, 2009
Source:
Wiley-Blackwell
Summary:
When cells cannot carry out the tasks required of them by our bodies, the result is disease. Nanobiotechnology researchers are looking for ways to allow synthetic systems take over simple cellular activities when they are absent from the cell. This requires transport systems that can encapsulate medications and other substances and release them in a controlled fashion at the right moment. Scientists have now developed a microcontainer that can hold thousands of individual "carrier units" -- a "capsosome" as a new approach to drug delivery.

When cells cannot carry out the tasks required of them by our bodies, the result is disease. Nanobiotechnology researchers are looking for ways to allow synthetic systems take over simple cellular activities when they are absent from the cell. This requires transport systems that can encapsulate medications and other substances and release them in a controlled fashion at the right moment.

Related Articles


The transporter must be able to interact with the surroundings in order to receive the signal to unload its cargo. A team led by Frank Caruso at the University of Melbourne has now developed a microcontainer that can hold thousands of individual "carrier units"—a "capsosome". These are polymer capsules in which liposomes have been embedded to form subcompartments.

Currently, the primary type of nanotransporter used for drugs is the capsule: Polymer capsules form stable containers that are semipermeable, which allows for communication with the surrounding medium. However, these are not suitable for the transport of small molecules because they can escape. Liposomes are good at protecting small drug molecules; however, they are often unstable and impermeable to substances from the environment. The Australian researchers have now combined the advantages of both systems in their capsosomes.

Capsosomes are produced by several steps. First, a layer of polymer is deposited onto small silica spheres. This polymer contains building blocks modified with cholesterol. Liposomes that have been loaded with an enzyme can be securely anchored to the cholesterol units and thus attached to the polymer film. Subsequently, more polymer layers are added and then cross-linked by disulfide bridges into a gel by means of a specially developed, very gentle cross-linking reaction. In the final step, the silica core is etched away without damaging the sensitive cargo.

Experiments with an enzyme as model cargo demonstrated that the liposomes remain intact and the cargo does not escape. Addition of a detergent releases the enzyme in a functional state. By means of the enzymatic reaction, which causes a color change of the solution, it was possible to determine the number of liposome compartments to be about 8000 per polymer capsule.

"Because the capsosomes are biodegradable and nontoxic", says Brigitte Staedler, a senior researcher in the group, "they would also be suitable for use as resorbable synthetic cell organelles and for the transport of drugs." In addition, the scientists are planning to encapsulate liposomes filled with different enzymes together and to equip them with specific "receivers" which would allow the individual cargo to be released in a targeted fashion. This would make it possible to use enzymatic reaction cascades for catalytic reaction processes.


Story Source:

The above story is based on materials provided by Wiley-Blackwell. Note: Materials may be edited for content and length.


Journal Reference:

  1. Frank Caruso. A Microreactor with Thousands of Subcompartments: Enzyme-Loaded Liposomes within Polymer Capsules. Angewandte Chemie International Edition, 2009, 48, No. 24, 4359-4362 DOI: 10.1002/anie.200900386

Cite This Page:

Wiley-Blackwell. "Drug Deliver With Nanotechnology: Capsules Encapsulated." ScienceDaily. ScienceDaily, 20 May 2009. <www.sciencedaily.com/releases/2009/05/090519134717.htm>.
Wiley-Blackwell. (2009, May 20). Drug Deliver With Nanotechnology: Capsules Encapsulated. ScienceDaily. Retrieved March 5, 2015 from www.sciencedaily.com/releases/2009/05/090519134717.htm
Wiley-Blackwell. "Drug Deliver With Nanotechnology: Capsules Encapsulated." ScienceDaily. www.sciencedaily.com/releases/2009/05/090519134717.htm (accessed March 5, 2015).

Share This


More From ScienceDaily



More Matter & Energy News

Thursday, March 5, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Did the Simpsons Figure out the Higgs Boson Particle Years Before Scientists

Did the Simpsons Figure out the Higgs Boson Particle Years Before Scientists

Buzz60 (Mar. 4, 2015) During a 1998 Simpsons episode, Homer Simpson scribbled a seemingly gibberish equation on a chalkboard. Turns out that equation is a shake off from predicting the actual nano mass of the God Particle. Patrick Jones (@Patrick_E_Jones) explains. Video provided by Buzz60
Powered by NewsLook.com
Wearables Now the Must-Haveables

Wearables Now the Must-Haveables

Reuters - Business Video Online (Mar. 3, 2015) Telecom company executives are meeting in Barcelona for the Mobile World Congress, the largest annual trade show for the wireless industry. As Ivor Bennett reports from the show wearable technology is one of the big themes. Video provided by Reuters
Powered by NewsLook.com
Forensic Holodeck Creates 3D Crime Scenes

Forensic Holodeck Creates 3D Crime Scenes

Reuters - Innovations Video Online (Mar. 3, 2015) A holodeck is no longer the preserve of TV sci-fi classic Star Trek, thanks to researchers from the Institute of Forensic Medicine Zurich, who have created what they say is the first system in the world to visualise the 3D data of forensic scans. Jim Drury saw it in operation. Video provided by Reuters
Powered by NewsLook.com
Solar Plane Passes New Test Ahead of World Tour

Solar Plane Passes New Test Ahead of World Tour

AFP (Mar. 2, 2015) A solar-powered plane made a third successful test flight in the United Arab Emirates on Monday ahead of a planned round-the-world tour to promote alternative energy. Duration: 01:05 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Space & Time

Matter & Energy

Computers & Math

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins