Featured Research

from universities, journals, and other organizations

Model For New Generation Of Blood Vessels Challenged

Date:
June 1, 2009
Source:
Uppsala University
Summary:
In-growth and new generation of blood vessels, which must take place if a wound is to heal or a tumor is to grow, have been thought to occur through a branching and further growth of a vessel against a chemical gradient of growth factors. Now Swedish researchers have shown that mechanical forces are considerably more important than was previously thought. The findings open up a new field for developing treatments.

In-growth and new generation of blood vessels, which must take place if a wound is to heal or a tumor is to grow, have been thought to occur through a branching and further growth of a vessel against a chemical gradient of growth factors. Now a research team at Uppsala University and its University Hospital has shown that mechanical forces are considerably more important than was previously thought. The findings, published today in the journal Nature Medicine, open up a new field for developing treatments.

Related Articles


New generation of blood vessels takes place in normal physiological processes, such as when a wound heals, children grow, or the mucous membrane of the womb is built up to be able to receive a fertilized egg. It is also a crucial mechanism in tumor diseases, rheumatism, and certain eye disorders, for example.

How new generation and in-growth of blood vessels takes place has not been fully understood. It has been assumed that the mechanisms are the same as those that occur in embryonic development, which is probably a great over-simplification. The formation of the vascular system in the fetus takes place in a well-organized and reproducible way, which means that we all have blood vessel systems that look very much the same. On the other hand, new generation of vessels in wound healing and tumor growth, for example, occurs in a chaotic environment where it is difficult to see that there would be well-defined gradients of growth factors, and it has not been possible to find evidence of any.

"Unlike these previous models, our findings show that in wound healing, in-growth of new blood vessels takes place via mechanical forces that pull already existing blood vessels into the wound when it heals," says Pär Gerwins, who directed the study and is a physician and interventional radiologist at Uppsala University Hospital as well as a researcher with the Department of Medical Biochemistry and Microbiology at Uppsala University.

It has long been known that specialized connecting tissue cells, so-called myofibroblasts, wander in and pull the wound together. In the study being published it is shown that this wound contraction governs the in-growth of new blood vessels. Since it is a matter, at least initially, of the expansion of already existent blood vessels that have continuous blood circulation, there is a rapid in-growth of fully functional vessels, which is what we see when a wound heals.

The study not only explains a fundamental biological mechanism but also provides clues for new therapeutic goals in treating various diseases. Since myofibroblasts exist in relatively large numbers in tumors and rheumatic joints, one potential strategy to try to block the contractive capacity of these connective tissue cells. The new model can also partially explain why treatment of tumor diseases with blood-vessel inhibiting substances has not been as successful as was hoped.

Finally, the model can partially explain the mechanism behind the positive effect of "vacuum-assisted wound closure," (VAC). This is a method of treatment for hard-to-heal wounds where an air-tight bandage is applied and then the pressure is reduced in the wound with the aid of suction, which creates a continuous mechanical pull in the underlying tissue. Blood-vessel-rich wound-healing tissue is thereby generated much more rapidly, which substantially hastens healing. It is hoped that it will now be possible to understand why some wounds do not heal and also to develop new types of wound treatment.


Story Source:

The above story is based on materials provided by Uppsala University. Note: Materials may be edited for content and length.


Journal Reference:

  1. Kilarski et al. Biomechanical regulation of blood vessel growth during tissue vascularization. Nature Medicine, 2009; DOI: 10.1038/nm.1985

Cite This Page:

Uppsala University. "Model For New Generation Of Blood Vessels Challenged." ScienceDaily. ScienceDaily, 1 June 2009. <www.sciencedaily.com/releases/2009/06/090601102015.htm>.
Uppsala University. (2009, June 1). Model For New Generation Of Blood Vessels Challenged. ScienceDaily. Retrieved March 29, 2015 from www.sciencedaily.com/releases/2009/06/090601102015.htm
Uppsala University. "Model For New Generation Of Blood Vessels Challenged." ScienceDaily. www.sciencedaily.com/releases/2009/06/090601102015.htm (accessed March 29, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Sunday, March 29, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

S. Leone in New Anti-Ebola Lockdown

S. Leone in New Anti-Ebola Lockdown

AFP (Mar. 28, 2015) — Sierra Leone imposed a three-day nationwide lockdown Friday for the second time in six months in a bid to prevent a resurgence of the deadly Ebola virus. Duration: 01:17 Video provided by AFP
Powered by NewsLook.com
These Popular Antibiotics Can Cause Permanent Nerve Damage

These Popular Antibiotics Can Cause Permanent Nerve Damage

Newsy (Mar. 27, 2015) — A popular class of antibiotic can leave patients in severe pain and even result in permanent nerve damage. Video provided by Newsy
Powered by NewsLook.com
WH Plan to Fight Antibiotic-Resistant Germs

WH Plan to Fight Antibiotic-Resistant Germs

AP (Mar. 27, 2015) — The White House on Friday announced a five-year plan to fight the threat posed by antibiotic-resistant bacteria amid fears that once-treatable germs could become deadly. (March 27) Video provided by AP
Powered by NewsLook.com
House Ready to Pass Medicare Doc Bill

House Ready to Pass Medicare Doc Bill

AP (Mar. 26, 2015) — In rare bipartisan harmony, congressional leaders pushed a $214 billion bill permanently blocking physician Medicare cuts toward House passage Thursday, moving lawmakers closer to resolving a problem that has plagued them for years. (March 26) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins