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New Pathway Found Underlying Pulmonary Hypertension

Date:
June 8, 2009
Source:
Journal of Clinical Investigation
Summary:
Pulmonary hypertension is an unremitting disease caused by a progressive increase in blood pressure in the blood vessels of the lung; it leads to heart failure and ultimately death. Currently there are limited treatment options. However, researchers have identified in mice a new molecular pathway underlying pulmonary hypertension that they hope might provide novel therapeutic targets.
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Pulmonary hypertension is an unremitting disease caused by a progressive increase in blood pressure in the blood vessels of the lung; it leads to heart failure and ultimately death. Currently there are limited treatment options. However, You-Yang Zhao and colleagues, at the University of Illinois College of Medicine, Chicago, have identified in mice a new molecular pathway underlying pulmonary hypertension that they hope might provide novel therapeutic targets.

In the study, mice lacking either caveolin 1, eNOS, or both proteins were used to determine that chronic eNOS activation, secondary to loss of caveolin-1, can lead to pulmonary hypertension. Further analysis revealed that the chronic eNOS activation that induced pulmonary hypertension was associated with impaired activity of the protein PKG because it was modified by a process known as nitration.

As lung tissue from patients with a form of pulmonary hypertension known as idiopathic pulmonary arterial hypertension exhibited evidence of increased eNOS activation and PKG nitration and reduced caveolin-1 expression, the authors suggest that preventing and/or reversing PKG nitration might be of benefit to individuals with idiopathic pulmonary arterial hypertension.


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The above story is based on materials provided by Journal of Clinical Investigation. Note: Materials may be edited for content and length.


Journal Reference:

  1. Persistent eNOS activation secondary to caveolin-1 deficiency induces pulmonary hypertension in mice and humans through PKG nitration. Journal of Clinical Investigation, June 1, 2009

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Journal of Clinical Investigation. "New Pathway Found Underlying Pulmonary Hypertension." ScienceDaily. ScienceDaily, 8 June 2009. <www.sciencedaily.com/releases/2009/06/090601182710.htm>.
Journal of Clinical Investigation. (2009, June 8). New Pathway Found Underlying Pulmonary Hypertension. ScienceDaily. Retrieved May 25, 2015 from www.sciencedaily.com/releases/2009/06/090601182710.htm
Journal of Clinical Investigation. "New Pathway Found Underlying Pulmonary Hypertension." ScienceDaily. www.sciencedaily.com/releases/2009/06/090601182710.htm (accessed May 25, 2015).

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