Featured Research

from universities, journals, and other organizations

Scientists Uncover Mode Of Action Of Enzyme Linked With Several Types Of Cancer

Date:
June 8, 2009
Source:
University of Montreal
Summary:
Scientists have discovered a key mechanism used by cells to efficiently distribute chromosomes to new cells during cell multiplication.

Scientists at the Institute for Research in Immunology and Cancer (IRIC) of the Université de Montréal have discovered a key mechanism used by cells to efficiently distribute chromosomes to new cells during cell multiplication.

Related Articles


Published in the journal Molecular Cell, the study is the first to demonstrate that this mechanism relies on the polo kinase, an enzyme implicated in several cancers. Inhibiting this mechanism could be key to developing effective therapies to treat cancer.

Each human cell contains, in its nucleus, all the coding instructions necessary to direct the cell's activities. A complete set of those instructions is referred to as a genome. Cancer cells are capable of altering their genome in order to promote uncontrolled growth. "Cancer cells achieve this by gaining or losing specific chromosomes, or by inducing structural defects in their genome," explains Damien D'Amours, Principal Investigator at IRIC and director of the study, "We discovered that the polo kinase, overexpressed in a broad range of human tumours, tells the chromosomes exactly when to condense during cell division."

Misregulation of the polo kinase is associated with cancers, thereby suggesting a link between defects in chromosome condensation and the formation of tumours. "Pharmaceutical companies and independent researchers are already working on the development of new cancer drugs to inhibit the activity of the polo kinase," points out Damien D'Amours, "Understanding this enzyme's mode of action should enable us to control it. Such knowledge may reveal itself to be key in developing effective therapies to treat cancer."

In a preview article commissioned by Molecular Cell, world leader in chromosome dynamics Tatsuya Hirano, of the Riken Advanced Science Institute in Japan, qualifies the research as a tour de force study that will help address outstanding questions in the field.


Story Source:

The above story is based on materials provided by University of Montreal. Note: Materials may be edited for content and length.


Journal References:

  1. Julie St-Pierre, Mélanie Douziech, Franck Bazile, Mirela Pascariu, Éric Bonneil, Véronique Sauvé, Hery Ratsima and Damien D'Amours. Polo Kinase Regulates Mitotic Chromosome Condensation by Hyperactivation of Condensin DNA Supercoiling Activity. Molecular Cell, 2009; 34 (4): 416 DOI: 10.1016/j.molcel.2009.04.013
  2. Tatsuya Hirano. Let's Play Polo in the Field of Condensation. Molecular Cell, 2009; 34 (4): 399 DOI: 10.1016/j.molcel.2009.05.002

Cite This Page:

University of Montreal. "Scientists Uncover Mode Of Action Of Enzyme Linked With Several Types Of Cancer." ScienceDaily. ScienceDaily, 8 June 2009. <www.sciencedaily.com/releases/2009/06/090603131435.htm>.
University of Montreal. (2009, June 8). Scientists Uncover Mode Of Action Of Enzyme Linked With Several Types Of Cancer. ScienceDaily. Retrieved January 31, 2015 from www.sciencedaily.com/releases/2009/06/090603131435.htm
University of Montreal. "Scientists Uncover Mode Of Action Of Enzyme Linked With Several Types Of Cancer." ScienceDaily. www.sciencedaily.com/releases/2009/06/090603131435.htm (accessed January 31, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Saturday, January 31, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

CDC: Get Vaccinated for Measles

CDC: Get Vaccinated for Measles

Reuters - US Online Video (Jan. 30, 2015) — The CDC is urging people to get vaccinated for measles amid an outbreak that began at Disneyland and has now infected more than 90 people. Linda So reports. Video provided by Reuters
Powered by NewsLook.com
Obama To Outline New Plan For Personalized Medicine

Obama To Outline New Plan For Personalized Medicine

Newsy (Jan. 30, 2015) — President Obama is expected to speak with drugmakers Friday about his Precision Medicine Initiative first introduced last week. Video provided by Newsy
Powered by NewsLook.com
NFL Concussions Down; Still on Parents' Minds

NFL Concussions Down; Still on Parents' Minds

AP (Jan. 30, 2015) — The NFL announced this week that the number of game concussions dropped by a quarter over last season. Still, the dangers of the sport still weigh on players, and parents&apos; minds. (Jan. 30) Video provided by AP
Powered by NewsLook.com
U.S. Wants to Analyze DNA from 1 Million People

U.S. Wants to Analyze DNA from 1 Million People

Reuters - US Online Video (Jan. 30, 2015) — The U.S. has proposed analyzing genetic information from more than 1 million American volunteers to learn how genetic variants affect health and disease. Rough Cut (no reporter narration). Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins