Featured Research

from universities, journals, and other organizations

Scientists Uncover Mode Of Action Of Enzyme Linked With Several Types Of Cancer

Date:
June 8, 2009
Source:
University of Montreal
Summary:
Scientists have discovered a key mechanism used by cells to efficiently distribute chromosomes to new cells during cell multiplication.

Scientists at the Institute for Research in Immunology and Cancer (IRIC) of the Université de Montréal have discovered a key mechanism used by cells to efficiently distribute chromosomes to new cells during cell multiplication.

Published in the journal Molecular Cell, the study is the first to demonstrate that this mechanism relies on the polo kinase, an enzyme implicated in several cancers. Inhibiting this mechanism could be key to developing effective therapies to treat cancer.

Each human cell contains, in its nucleus, all the coding instructions necessary to direct the cell's activities. A complete set of those instructions is referred to as a genome. Cancer cells are capable of altering their genome in order to promote uncontrolled growth. "Cancer cells achieve this by gaining or losing specific chromosomes, or by inducing structural defects in their genome," explains Damien D'Amours, Principal Investigator at IRIC and director of the study, "We discovered that the polo kinase, overexpressed in a broad range of human tumours, tells the chromosomes exactly when to condense during cell division."

Misregulation of the polo kinase is associated with cancers, thereby suggesting a link between defects in chromosome condensation and the formation of tumours. "Pharmaceutical companies and independent researchers are already working on the development of new cancer drugs to inhibit the activity of the polo kinase," points out Damien D'Amours, "Understanding this enzyme's mode of action should enable us to control it. Such knowledge may reveal itself to be key in developing effective therapies to treat cancer."

In a preview article commissioned by Molecular Cell, world leader in chromosome dynamics Tatsuya Hirano, of the Riken Advanced Science Institute in Japan, qualifies the research as a tour de force study that will help address outstanding questions in the field.


Story Source:

The above story is based on materials provided by University of Montreal. Note: Materials may be edited for content and length.


Journal References:

  1. Julie St-Pierre, Mélanie Douziech, Franck Bazile, Mirela Pascariu, Éric Bonneil, Véronique Sauvé, Hery Ratsima and Damien D'Amours. Polo Kinase Regulates Mitotic Chromosome Condensation by Hyperactivation of Condensin DNA Supercoiling Activity. Molecular Cell, 2009; 34 (4): 416 DOI: 10.1016/j.molcel.2009.04.013
  2. Tatsuya Hirano. Let's Play Polo in the Field of Condensation. Molecular Cell, 2009; 34 (4): 399 DOI: 10.1016/j.molcel.2009.05.002

Cite This Page:

University of Montreal. "Scientists Uncover Mode Of Action Of Enzyme Linked With Several Types Of Cancer." ScienceDaily. ScienceDaily, 8 June 2009. <www.sciencedaily.com/releases/2009/06/090603131435.htm>.
University of Montreal. (2009, June 8). Scientists Uncover Mode Of Action Of Enzyme Linked With Several Types Of Cancer. ScienceDaily. Retrieved July 23, 2014 from www.sciencedaily.com/releases/2009/06/090603131435.htm
University of Montreal. "Scientists Uncover Mode Of Action Of Enzyme Linked With Several Types Of Cancer." ScienceDaily. www.sciencedaily.com/releases/2009/06/090603131435.htm (accessed July 23, 2014).

Share This




More Health & Medicine News

Wednesday, July 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Courts Conflicted Over Healthcare Law

Courts Conflicted Over Healthcare Law

AP (July 22, 2014) — Two federal appeals courts issued conflicting rulings Tuesday on the legality of the federally-run healthcare exchange that operates in 36 states. (July 22) Video provided by AP
Powered by NewsLook.com
Why Do People Believe We Only Use 10 Percent Of Our Brains?

Why Do People Believe We Only Use 10 Percent Of Our Brains?

Newsy (July 22, 2014) — The new sci-fi thriller "Lucy" is making people question whether we really use all our brainpower. But, as scientists have insisted for years, we do. Video provided by Newsy
Powered by NewsLook.com
Scientists Find New Way To Make Human Platelets

Scientists Find New Way To Make Human Platelets

Newsy (July 22, 2014) — Boston scientists have discovered a new way to create fully functioning human platelets using a bioreactor and human stem cells. Video provided by Newsy
Powered by NewsLook.com
Gilead's $1000-a-Pill Drug Could Cure Hep C in HIV-Positive People

Gilead's $1000-a-Pill Drug Could Cure Hep C in HIV-Positive People

TheStreet (July 21, 2014) — New research shows Gilead Science's drug Sovaldi helps in curing hepatitis C in those who suffer from HIV. In a medical study, the combination of Gilead's Hep C drug with anti-viral drug Ribavirin cured 76% of HIV-positive patients suffering from the most common hepatitis C strain. Hepatitis C and related complications have been a top cause of death in HIV-positive patients. Typical medication used to treat the disease, including interferon proteins, tended to react badly with HIV drugs. However, Sovaldi's %1,000-a-pill price tag could limit the number of patients able to access the treatment. TheStreet's Keris Lahiff reports from New York. Video provided by TheStreet
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins