Featured Research

from universities, journals, and other organizations

Electronic Pill Shows Its Smarts By Measuring pH Levels In Digestive Tract

Date:
June 4, 2009
Source:
New York- Presbyterian Hospital/Weill Cornell Medical Center/Weill Cornell Medical College
Summary:
An electronic diagnostic tool called the SmartPill is swallowed by patients in order to take measurements as it travels through the gastrointestinal tract. A new study by physician-scientists used the device in patients with mild to moderate ulcerative colitis (UC), determining that they have significantly more acidic pH in their colons, compared with the average person -- a finding that may impact treatment strategy.

An electronic diagnostic tool called the SmartPill is swallowed by patients in order to take measurements as it travels through the gastrointestinal tract. A new study by physician-scientists at NewYork-Presbyterian/Weill Cornell Medical Center used the device in patients with mild to moderate ulcerative colitis (UC), determining that they have significantly more acidic pH in their colons, compared with the average person — a finding that may impact treatment strategy.

"By using the SmartPill to measure the pH throughout the digestive tract, we were able to see how the pH levels can vary in patients with ulcerative colitis. This may help us understand why some drug treatments are more effective than others," says Dr. Brian Bosworth, lead investigator, assistant professor of medicine at Weill Cornell Medical College, and a Crohn's and colitis specialist at the Jill Roberts Center for Inflammatory Bowel Diseases at NewYork-Presbyterian Hospital/Weill Cornell Medical Center.

Mesalamines are the mainstay drug therapy for the induction and maintenance of remission in patients with mild to moderate UC. Their efficacy is dependent on how well the drug is delivered to the active site of the disease. Several mesalamines have a delivery system that is dependent upon a specific pH in order to release. However, since the pH levels in the GI tract can vary, the researchers say, this could impact the proper release and efficacy of the medication.

In the study, five patients with mild to moderate ulcerative colitis (UC) and five healthy control patients swallowed the SmartPill. While all study participants reached a pH of 7, the UC patients reached this level more slowly than those without UC. Furthermore, the amount of time the colon maintained a pH greater than 6 or greater than 7 was less in the UC patients. The majority of mesalamines dissolve at a pH greater than or equal to 7, however, there is a more recently approved medication that initiates release of mesalamine at pH greater than or equal to 6.

Administered in the physician's office, the SmartPill allows that patient to go about their normal routine during the course of the test. As the SmartPill Capsule passes through the GI tract, it transmits data — including pressure, pH and temperature — to a SmartPill Data Receiver worn by the patient. Once the single-use capsule has passed from the body, the patient returns the Data Receiver to the physician who then can download the collected data to a computer, where it can be analyzed.

The study was presented June 3 at the Digestive Disease Week (DDW) meeting in Chicago, Ill.

The study's co-authors include Drs. Douglas M. Weine and Ellen J. Scherl of NewYork-Presbyterian Hospital/Weill Cornell Medical Center, and Michelle Cohen of the Albert Einstein College of Medicine, Bronx, N.Y.

About Ulcerative Colitis

Ulcerative colitis (UC) is a form of colitis, a disease of the intestine, specifically the large intestine or colon, that includes characteristic ulcers, or open sores, in the colon. Because the inflammation makes the colon empty frequently, symptoms typically include diarrhea (sometimes bloody) and often abdominal pain.


Story Source:

The above story is based on materials provided by New York- Presbyterian Hospital/Weill Cornell Medical Center/Weill Cornell Medical College. Note: Materials may be edited for content and length.


Cite This Page:

New York- Presbyterian Hospital/Weill Cornell Medical Center/Weill Cornell Medical College. "Electronic Pill Shows Its Smarts By Measuring pH Levels In Digestive Tract." ScienceDaily. ScienceDaily, 4 June 2009. <www.sciencedaily.com/releases/2009/06/090603180926.htm>.
New York- Presbyterian Hospital/Weill Cornell Medical Center/Weill Cornell Medical College. (2009, June 4). Electronic Pill Shows Its Smarts By Measuring pH Levels In Digestive Tract. ScienceDaily. Retrieved July 24, 2014 from www.sciencedaily.com/releases/2009/06/090603180926.htm
New York- Presbyterian Hospital/Weill Cornell Medical Center/Weill Cornell Medical College. "Electronic Pill Shows Its Smarts By Measuring pH Levels In Digestive Tract." ScienceDaily. www.sciencedaily.com/releases/2009/06/090603180926.htm (accessed July 24, 2014).

Share This




More Health & Medicine News

Thursday, July 24, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

New Painkiller Designed To Discourage Abuse: Will It Work?

New Painkiller Designed To Discourage Abuse: Will It Work?

Newsy (July 24, 2014) The FDA approved Targiniq ER on Wednesday, a painkiller designed to keep users from abusing it. Like any new medication, however, it has doubters. Video provided by Newsy
Powered by NewsLook.com
Doctor At Forefront Of Fighting Ebola Outbreak Gets Ebola

Doctor At Forefront Of Fighting Ebola Outbreak Gets Ebola

Newsy (July 24, 2014) Sheik Umar Khan has treated many of the people infected in the Ebola outbreak, and now he's become one of them. Video provided by Newsy
Powered by NewsLook.com
Condemned Man's US Execution Takes Nearly Two Hours

Condemned Man's US Execution Takes Nearly Two Hours

AFP (July 24, 2014) America's death penalty debate raged Thursday after it took nearly two hours for Arizona to execute a prisoner who lost a Supreme Court battle challenging the experimental lethal drug cocktail. Duration: 00:55 Video provided by AFP
Powered by NewsLook.com
China's Ageing Millions Look Forward to Bleak Future

China's Ageing Millions Look Forward to Bleak Future

AFP (July 24, 2014) China's elderly population is expanding so quickly that children struggle to look after them, pushing them to do something unexpected in Chinese society- move their parents into a nursing home. Duration: 02:07 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins