Featured Research

from universities, journals, and other organizations

Clearing Pneumococcal Bacteria From The Upper Airways

Date:
June 17, 2009
Source:
Journal of Clinical Investigation
Summary:
The bacterium Streptococcus pneumoniae can be found in the upper airways (the nose, mouth, and throat) of most children. When living in the upper airways, S. pneumoniae is harmless. However, if the bacteria are carried to other sites, they cause disease, for example ear infections and life-threatening pneumonia.

The bacterium Streptococcus pneumoniae can be found in the upper airways (the nose, mouth, and throat) of most children. When living in the upper airways, S. pneumoniae is harmless. However, if the bacteria are carried to other sites, they cause disease, for example ear infections and life-threatening pneumonia.

Long-term studies have shown that the upper airways of children do not continuously harbor S. pneumoniae. Rather, it is a cycle of bacterial clearance followed by recolonization, with little known about how the bacteria are cleared.

However, Jeffrey Weiser and colleagues, at the University of Pennsylvania School of Medicine, Philadelphia, have now identified a cellular immune mechanism by which mice clear S. pneumoniae from their upper airways.

In the study, they found that efficient clearance of S. pneumoniae from the upper airways of mice that had not been previously colonized by the bacteria required immune cells known as Th17 cells (CD4+ T cells that secrete the soluble factor IL-17). Further analysis indicated that these cells were required to sustain the recruitment of other immune cells known as monocyte/macrophages, which effectively cleared the pneumococcal bacteria.

The authors suggest these data provide a new model for immune-mediated clearance of S. pneumoniae from the upper airways.



Story Source:

The above story is based on materials provided by Journal of Clinical Investigation. Note: Materials may be edited for content and length.


Journal Reference:

  1. Cellular effectors mediating Th17-dependent clearance of pneumococcal colonization in mice. Journal Of Clinical Investigation, June 8, 2009

Cite This Page:

Journal of Clinical Investigation. "Clearing Pneumococcal Bacteria From The Upper Airways." ScienceDaily. ScienceDaily, 17 June 2009. <www.sciencedaily.com/releases/2009/06/090608182429.htm>.
Journal of Clinical Investigation. (2009, June 17). Clearing Pneumococcal Bacteria From The Upper Airways. ScienceDaily. Retrieved September 16, 2014 from www.sciencedaily.com/releases/2009/06/090608182429.htm
Journal of Clinical Investigation. "Clearing Pneumococcal Bacteria From The Upper Airways." ScienceDaily. www.sciencedaily.com/releases/2009/06/090608182429.htm (accessed September 16, 2014).

Share This



More Health & Medicine News

Tuesday, September 16, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

President To Send 3,000 Military Personnel To Fight Ebola

President To Send 3,000 Military Personnel To Fight Ebola

Newsy (Sep. 16, 2014) President Obama is expected to send 3,000 troops to West Africa as part of the effort to contain Ebola's spread. Video provided by Newsy
Powered by NewsLook.com
Man Floats for 31 Hours in Gulf Waters

Man Floats for 31 Hours in Gulf Waters

AP (Sep. 16, 2014) A Texas man is lucky to be alive after he and three others floated for more than a day in the Gulf of Mexico when their boat sank during a fishing trip. (Sept. 16) Video provided by AP
Powered by NewsLook.com
EU Ministers and Experts Meet to Discuss Ebola Reponse

EU Ministers and Experts Meet to Discuss Ebola Reponse

AFP (Sep. 15, 2014) The European Commission met on Monday to coordinate aid that the EU can offer to African countries affected by the Ebola outbreak. Duration: 00:58 Video provided by AFP
Powered by NewsLook.com
Despite The Risks, Antibiotics Still Overprescribed For Kids

Despite The Risks, Antibiotics Still Overprescribed For Kids

Newsy (Sep. 15, 2014) A new study finds children are prescribed antibiotics twice as often as is necessary. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

    Environment News

      Technology News



      Save/Print:
      Share:

      Free Subscriptions


      Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

      Get Social & Mobile


      Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

      Have Feedback?


      Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
      Mobile: iPhone Android Web
      Follow: Facebook Twitter Google+
      Subscribe: RSS Feeds Email Newsletters
      Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins