Featured Research

from universities, journals, and other organizations

Stopping Diabetes Damage With Vitamin C

Date:
June 10, 2009
Source:
University of Oklahoma
Summary:
Researchers have found a way to stop the damage caused by type 1 diabetes with the combination of insulin and a common vitamin found in most medicine cabinets.

Researchers at the Harold Hamm Oklahoma Diabetes Center have found a way to stop the damage caused by Type 1 diabetes with the combination of insulin and a common vitamin found in most medicine cabinets.

While neither therapy produced desired results when used alone, the combination of insulin to control blood sugar together with the use of Vitamin C, stopped blood vessel damage caused by the disease in patients with poor glucose control.

"We had tested this theory on research models, but this is the first time anyone has shown the therapy's effectiveness in people," said Michael Ihnat, Ph.D., principal investigator and a pharmacologist at the OU College of Medicine Department of Cell Biology.

Ihnat said they are now studying the therapy in patients with Type 2 diabetes.

The goal of the work being done by Ihnat and British scientists from the University of Warwick led by Dr. Antonio Ceriello is to find a way to stop the damage to blood vessels that is caused by diabetes. The damage, known as endothelial dysfunction, is associated with most forms of cardiovascular disease such as hypertension, coronary artery disease, chronic heart failure, peripheral artery disease, diabetes and chronic renal failure.

By reducing or stopping the damage, patients with diabetes could avoid some of the painful and fatal consequences of the disease that include heart disease, reduced circulation and amputation, kidney disease and diabetic retinopathy, which can lead to blindness.

Insulin and many other drugs have long been used to control blood sugar, but Ihnat – in an earlier project with scientists in Italy and Hungary – found that cells have a "memory" that causes damage to continue even when blood sugar is controlled. By adding antioxidants like Vitamin C, Ihnat found that cell "memory" disappeared and cell function and oxidation stress were normalized.

"We have speculated that this happens with endothelial dysfunction, but we did not know until now if it was effective in humans. We finally were able to test it and proved it to be true," Ihnat said. "For patients with diabetes, this means simply getting their glucose under control is not enough. An antioxidant-based therapy combined with glucose control will give patients more of an advantage and lessen the chance of complications with diabetes."

While researchers do suggest diabetic patients eat foods and take multivitamins rich in antioxidants like Vitamin C, they warn that additional study is needed. The Vitamin C utilized in their study was given at very high doses and administered directly into the blood stream, so it is unlikely someone would get similar results with an over-the-counter vitamin supplement.

The team is now working to determine how antioxidants work at the molecular level to halt the destructive chain reaction set in motion by high blood sugar levels. In addition, they are evaluating several other antioxidants with an ultimate hope that their work will translate into simple, effective and inexpensive treatments for the control of diabetes.

Dr. Ihnat's latest work was funded by the VA Medical Center.


Story Source:

The above story is based on materials provided by University of Oklahoma. Note: Materials may be edited for content and length.


Journal Reference:

  1. Ceriello et al. Long-term glycemic control influences the long-lasting effect of hyperglycemia on endothelial function in type 1 diabetes. Journal of Clinical Endocrinology & Metabolism, 2009; DOI: 10.1210/jc.2009-0762

Cite This Page:

University of Oklahoma. "Stopping Diabetes Damage With Vitamin C." ScienceDaily. ScienceDaily, 10 June 2009. <www.sciencedaily.com/releases/2009/06/090609122232.htm>.
University of Oklahoma. (2009, June 10). Stopping Diabetes Damage With Vitamin C. ScienceDaily. Retrieved July 31, 2014 from www.sciencedaily.com/releases/2009/06/090609122232.htm
University of Oklahoma. "Stopping Diabetes Damage With Vitamin C." ScienceDaily. www.sciencedaily.com/releases/2009/06/090609122232.htm (accessed July 31, 2014).

Share This




More Health & Medicine News

Thursday, July 31, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

House Republicans Vote to Sue Obama Over Healthcare Law

House Republicans Vote to Sue Obama Over Healthcare Law

Reuters - US Online Video (July 31, 2014) The Republican-led House of Representatives votes to sue President Obama, accusing him of overstepping his executive authority in making changes to the Affordable Care Act. Mana Rabiee reports. Video provided by Reuters
Powered by NewsLook.com
Despite Health Questions, E-Cigs Are Beneficial: Study

Despite Health Questions, E-Cigs Are Beneficial: Study

Newsy (July 31, 2014) Citing 81 previous studies, new research out of London suggests the benefits of smoking e-cigarettes instead of regular ones outweighs the risks. Video provided by Newsy
Powered by NewsLook.com
Dangerous Bacteria Kills One in Florida

Dangerous Bacteria Kills One in Florida

AP (July 31, 2014) Sarasota County, Florida health officials have issued a warning against eating raw oysters and exposing open wounds to coastal and inland waters after a dangerous bacteria killed one person and made another sick. (July 31) Video provided by AP
Powered by NewsLook.com
Health Insurers' Profits Slide

Health Insurers' Profits Slide

Reuters - Business Video Online (July 30, 2014) Obamacare-related costs were said to be behind the profit plunge at Wellpoint and Humana, but Wellpoint sees the new exchanges boosting its earnings for the full year. Fred Katayama reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



    Save/Print:
    Share:

    Free Subscriptions


    Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

    Get Social & Mobile


    Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

    Have Feedback?


    Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
    Mobile: iPhone Android Web
    Follow: Facebook Twitter Google+
    Subscribe: RSS Feeds Email Newsletters
    Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins