Featured Research

from universities, journals, and other organizations

Brain Molecule Reduces Food Intake

Date:
June 10, 2009
Source:
The Endocrine Society
Summary:
Researchers have identified a new appetite suppressant for promoting weight loss that they say works in rodents and may one day be used to develop an effective anti-obesity treatment.

Researchers at Imperial College London have identified a new appetite suppressant for promoting weight loss that they say works in rodents and may one day be used to develop an effective anti-obesity treatment. Results of the new study were presented at The Endocrine Society's 91st Annual Meeting in Washington, D.C.

Related Articles


The experimental treatment, prokineticin 2, is a recently discovered signaling molecule that occurs naturally in the part of the brain that helps control hunger. Both lean and obese mice treated with PK2 for 5 days lost almost 5 percent of their body weight, the authors reported.

"This is a greater weight loss than people achieve with current nonsurgical weight loss therapies," said study co-author Waljit Dhillo, a clinical senior lecturer at Imperial College London.

The researchers first dissolved a commercially available form of PK2 (from PeproTech Ltd.) in saline and injected it into the brain of 12 rats, which were allowed to eat as much as they wanted for 24 hours. Compared with 12 control rats that received only saline injections, the treated rats ate much less food; in the first hour alone, their food intake was 86 percent less.

PK2 did not affect movement, behavior or the ability to burn off calories, the authors reported.

To establish whether PK2 could be a potential anti-obesity treatment, the investigators changed the route of drug administration to be similar to the way patients with diabetes inject insulin—into the stomach. For 5 days, 10 lean mice and 10 obese mice received two PK2 injections a day into the abdomen. Again, the treated mice ate much less than did the control mice, which resulted in weight loss of almost 5 percent of their body weight.

"Our research shows that PK2 reduces hunger," Dhillo said. "The results hold the promise that PK2 may be developed as a drug to treat obesity, which could help the millions of people suffering from obesity and its consequences."

Dhillo and co-workers plan to conduct longer-term studies of PK2 in animals before proceeding to human studies.

Neekhil Patel, a student at Imperial College London, will present the study findings at the meeting. Other institutions that collaborated with the study were the Wellcome Trust Sanger Institute, Cambridge, U.K., and the University of Nottingham and the RenaSci Consultancy, both in Nottingham, U.K. The U.K. Medical Research Council and the National Institute for Health Research helped fund this study, as did an Integrative Mammalian Biology Capacity Building Award.


Story Source:

The above story is based on materials provided by The Endocrine Society. Note: Materials may be edited for content and length.


Cite This Page:

The Endocrine Society. "Brain Molecule Reduces Food Intake." ScienceDaily. ScienceDaily, 10 June 2009. <www.sciencedaily.com/releases/2009/06/090610091228.htm>.
The Endocrine Society. (2009, June 10). Brain Molecule Reduces Food Intake. ScienceDaily. Retrieved October 31, 2014 from www.sciencedaily.com/releases/2009/06/090610091228.htm
The Endocrine Society. "Brain Molecule Reduces Food Intake." ScienceDaily. www.sciencedaily.com/releases/2009/06/090610091228.htm (accessed October 31, 2014).

Share This



More Mind & Brain News

Friday, October 31, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Alzheimer’s Hope

Alzheimer’s Hope

Ivanhoe (Oct. 31, 2014) A new drug, BCI-838 offers new hope to halt and possibly reverse the damage of Alzheimer’s disease. Video provided by Ivanhoe
Powered by NewsLook.com
Studying Effects of Music on Dementia Patients

Studying Effects of Music on Dementia Patients

AP (Oct. 30, 2014) The University of Wisconsin-Milwaukee is studying the popular Music and Memory program to see if music, which helps improve the mood of Alzheimer's patients, can also reduce the use of prescription drugs for those suffering from dementia. (Oct. 30) Video provided by AP
Powered by NewsLook.com
Techy Tots Are Forefront of London's Baby Show

Techy Tots Are Forefront of London's Baby Show

AP (Oct. 28, 2014) Moms and Dads get a more hands-on approach to parenting with tech-centric products for raising their little ones. (Oct. 28) Video provided by AP
Powered by NewsLook.com
Cocoa Could Be As Good For Memory As It Is For A Sweet Tooth

Cocoa Could Be As Good For Memory As It Is For A Sweet Tooth

Newsy (Oct. 27, 2014) Researchers have come up with another reason why dark chocolate is good for your health. A substance in the treat can reportedly help with memory. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins