Featured Research

from universities, journals, and other organizations

Brain Molecule Reduces Food Intake

Date:
June 10, 2009
Source:
The Endocrine Society
Summary:
Researchers have identified a new appetite suppressant for promoting weight loss that they say works in rodents and may one day be used to develop an effective anti-obesity treatment.

Researchers at Imperial College London have identified a new appetite suppressant for promoting weight loss that they say works in rodents and may one day be used to develop an effective anti-obesity treatment. Results of the new study were presented at The Endocrine Society's 91st Annual Meeting in Washington, D.C.

Related Articles


The experimental treatment, prokineticin 2, is a recently discovered signaling molecule that occurs naturally in the part of the brain that helps control hunger. Both lean and obese mice treated with PK2 for 5 days lost almost 5 percent of their body weight, the authors reported.

"This is a greater weight loss than people achieve with current nonsurgical weight loss therapies," said study co-author Waljit Dhillo, a clinical senior lecturer at Imperial College London.

The researchers first dissolved a commercially available form of PK2 (from PeproTech Ltd.) in saline and injected it into the brain of 12 rats, which were allowed to eat as much as they wanted for 24 hours. Compared with 12 control rats that received only saline injections, the treated rats ate much less food; in the first hour alone, their food intake was 86 percent less.

PK2 did not affect movement, behavior or the ability to burn off calories, the authors reported.

To establish whether PK2 could be a potential anti-obesity treatment, the investigators changed the route of drug administration to be similar to the way patients with diabetes inject insulin—into the stomach. For 5 days, 10 lean mice and 10 obese mice received two PK2 injections a day into the abdomen. Again, the treated mice ate much less than did the control mice, which resulted in weight loss of almost 5 percent of their body weight.

"Our research shows that PK2 reduces hunger," Dhillo said. "The results hold the promise that PK2 may be developed as a drug to treat obesity, which could help the millions of people suffering from obesity and its consequences."

Dhillo and co-workers plan to conduct longer-term studies of PK2 in animals before proceeding to human studies.

Neekhil Patel, a student at Imperial College London, will present the study findings at the meeting. Other institutions that collaborated with the study were the Wellcome Trust Sanger Institute, Cambridge, U.K., and the University of Nottingham and the RenaSci Consultancy, both in Nottingham, U.K. The U.K. Medical Research Council and the National Institute for Health Research helped fund this study, as did an Integrative Mammalian Biology Capacity Building Award.


Story Source:

The above story is based on materials provided by The Endocrine Society. Note: Materials may be edited for content and length.


Cite This Page:

The Endocrine Society. "Brain Molecule Reduces Food Intake." ScienceDaily. ScienceDaily, 10 June 2009. <www.sciencedaily.com/releases/2009/06/090610091228.htm>.
The Endocrine Society. (2009, June 10). Brain Molecule Reduces Food Intake. ScienceDaily. Retrieved December 20, 2014 from www.sciencedaily.com/releases/2009/06/090610091228.htm
The Endocrine Society. "Brain Molecule Reduces Food Intake." ScienceDaily. www.sciencedaily.com/releases/2009/06/090610091228.htm (accessed December 20, 2014).

Share This


More From ScienceDaily



More Mind & Brain News

Saturday, December 20, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Researchers Test Colombian Village With High Alzheimer's Rates

Researchers Test Colombian Village With High Alzheimer's Rates

AFP (Dec. 19, 2014) In Yarumal, a village in N. Colombia, Alzheimer's has ravaged a disproportionately large number of families. A genetic "curse" that may pave the way for research on how to treat the disease that claims a new victim every four seconds. Duration: 02:42 Video provided by AFP
Powered by NewsLook.com
Double-Amputee Becomes First To Move Two Prosthetic Arms With His Mind

Double-Amputee Becomes First To Move Two Prosthetic Arms With His Mind

Buzz60 (Dec. 19, 2014) A double-amputee makes history by becoming the first person to wear and operate two prosthetic arms using only his mind. Jen Markham has the story. Video provided by Buzz60
Powered by NewsLook.com
Prenatal Exposure To Pollution Might Increase Autism Risk

Prenatal Exposure To Pollution Might Increase Autism Risk

Newsy (Dec. 18, 2014) Harvard researchers found children whose mothers were exposed to high pollution levels in the third trimester were twice as likely to develop autism. Video provided by Newsy
Powered by NewsLook.com
Yoga Could Be As Beneficial For The Heart As Walking, Biking

Yoga Could Be As Beneficial For The Heart As Walking, Biking

Newsy (Dec. 17, 2014) Yoga can help your weight, blood pressure, cholesterol and heart just as much as biking and walking does, a new study suggests. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins