Featured Research

from universities, journals, and other organizations

Fifty-one Genes Predict Breast Cancer Survival

Date:
June 15, 2009
Source:
University of Gothenburg
Summary:
It may be possible in the future to use a specimen from the tumor to determine which patients with breast cancer have a good chance of overcoming the disease, and which patients should be given more intensive treatments. Fifty-one genes may together provide information about the prognosis for an individual patient.

It may be possible in the future to use a specimen from the tumour to determine which patients with breast cancer have a good chance of overcoming the disease, and which patients should be given more intensive treatments. Fifty-one genes may together provide information about the prognosis for an individual patient. These are the conclusions of a thesis presented at the Sahlgrenska Academy, University of Gothenburg, Sweden.

The research group has analysed specimens from a number of breast tumours, both from patients that died from the disease and from patients surviving at least 10 years from diagnosis. The levels of expression of 51 genes differed between the two groups. It should be possible to use the differences in order to classify the patients into one of two groups: a favourable prognosis group and a poor prognosis group.

"Many breast cancer patients are currently overtreated, while some are undertreated. If it was possible to identify patients with poor prognosis, it would be possible to use greater treatment resources on these patients. At the same time, patients with a favourable prognosis could avoid unnecessary treatment", says Elin Karlsson who successfully defended her thesis on June 5.

Comparing the amounts of the gene products of these 51 genes with data from a previous study has allowed the research team to show that the genes have the ability to predict survival also for the new material.

The research group has also studied the protein BTG2, and shown that it is involved at several levels in the tumours that were examined. The protein was present more often in specimens from patients who had survived at least 5 years after diagnosis than in patients who had died within 5 years from diagnosis. It has been previously determined that this protein is a tumour suppressor, but the study at the Sahlgrenska Academy is the first to indicate it as a prognostic marker.

"We consider it to be a promising marker: it will maybe be possible to use it to determine which patients with breast cancer require particularly close surveillance. More research, however, will be required in


Story Source:

The above story is based on materials provided by University of Gothenburg. Note: Materials may be edited for content and length.


Cite This Page:

University of Gothenburg. "Fifty-one Genes Predict Breast Cancer Survival." ScienceDaily. ScienceDaily, 15 June 2009. <www.sciencedaily.com/releases/2009/06/090610160908.htm>.
University of Gothenburg. (2009, June 15). Fifty-one Genes Predict Breast Cancer Survival. ScienceDaily. Retrieved April 19, 2014 from www.sciencedaily.com/releases/2009/06/090610160908.htm
University of Gothenburg. "Fifty-one Genes Predict Breast Cancer Survival." ScienceDaily. www.sciencedaily.com/releases/2009/06/090610160908.htm (accessed April 19, 2014).

Share This



More Health & Medicine News

Saturday, April 19, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

'Holy Grail' Of Weight Loss? New Find Could Be It

'Holy Grail' Of Weight Loss? New Find Could Be It

Newsy (Apr. 18, 2014) In a potential breakthrough for future obesity treatments, scientists have used MRI scans to pinpoint brown fat in a living adult for the first time. Video provided by Newsy
Powered by NewsLook.com
Little Progress Made In Fighting Food Poisoning, CDC Says

Little Progress Made In Fighting Food Poisoning, CDC Says

Newsy (Apr. 18, 2014) A new report shows rates of two foodborne infections increased in the U.S. in recent years, while salmonella actually dropped 9 percent. Video provided by Newsy
Powered by NewsLook.com
Scientists Create Stem Cells From Adult Skin Cells

Scientists Create Stem Cells From Adult Skin Cells

Newsy (Apr. 17, 2014) The breakthrough could mean a cure for some serious diseases and even the possibility of human cloning, but it's all still a way off. Video provided by Newsy
Powered by NewsLook.com
Obama: 8 Million Healthcare Signups

Obama: 8 Million Healthcare Signups

AP (Apr. 17, 2014) President Barack Obama gave a briefing Thursday announcing 8 million people have signed up under the Affordable Care Act. He blasted continued Republican efforts to repeal the law. (April 17) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins