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Identifying The Potential For Tamoxifen Resistance In Patients

Date:
June 25, 2009
Source:
American Society for Biochemistry and Molecular Biology
Summary:
Tamoxifen is a widely used and highly successful drug in the treatment of breast cancer, though resistance to tamoxifen is still a concern in recurrent disease, since therapy resistant metastatic tumor cells are a major cause of death. Now, researchers have uncovered a protein profile that may accurately predict whether a cancer will be tamoxifen resistant.

Tamoxifen is a widely used and highly successful drug in the treatment of breast cancer, though resistance to tamoxifen is still a concern in recurrent disease (affecting 25-35% of patients), since therapy resistant metastatic tumor cells are a major cause of death. Researchers have uncovered a protein profile that may accurately predict whether a cancer will be tamoxifen resistant.

Arzu Umar and colleagues in the Netherlands and Washington examined thousands of tumor cells taken from 51 tamoxifen therapy-sensitive and therapy-resistant tumors using a combination of proteomic and mass-spectrometry approaches. Their analysis revealed a set of 100 proteins that were expressed at different abundance levels in the two tumor groups, highlighting a potential profile for tamoxifen resistance.

In addition, they analyzed the most significantly altered protein, called extracellular matrix metalloproteinase inducer, or EMMPRIN, in a separate set 156 breast tumor tissue samples. EMMPRIN levels were higher in tamoxifen-resistant tumors and significantly associated with an earlier tumor progression following first line tamoxifen treatment and poor clinical outcome, suggesting EMMPRIN may be a reliable marker for highly aggressive breast cancer.

While further work with additional samples will be needed to validate these potential markers, the authors note this profile could be clinically useful, especially considering their approach used minute amounts of tissue samples, making it applicable at even the earliest tumor stages.


Story Source:

The above story is based on materials provided by American Society for Biochemistry and Molecular Biology. Note: Materials may be edited for content and length.


Journal Reference:

  1. Umar et al. Identification of a Putative Protein Profile Associated with Tamoxifen Therapy Resistance in Breast Cancer. Molecular & Cellular Proteomics, 2009; 8 (6): 1278 DOI: 10.1074/mcp.M800493-MCP200

Cite This Page:

American Society for Biochemistry and Molecular Biology. "Identifying The Potential For Tamoxifen Resistance In Patients." ScienceDaily. ScienceDaily, 25 June 2009. <www.sciencedaily.com/releases/2009/06/090610185528.htm>.
American Society for Biochemistry and Molecular Biology. (2009, June 25). Identifying The Potential For Tamoxifen Resistance In Patients. ScienceDaily. Retrieved September 20, 2014 from www.sciencedaily.com/releases/2009/06/090610185528.htm
American Society for Biochemistry and Molecular Biology. "Identifying The Potential For Tamoxifen Resistance In Patients." ScienceDaily. www.sciencedaily.com/releases/2009/06/090610185528.htm (accessed September 20, 2014).

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